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C DeFranco et al.
Molecular biology of the cell, 9(7), 1695-1708 (1998-07-11)
Association of mRNA with the cytoskeleton represents a fundamental aspect of RNA physiology likely involved in mRNA transport, anchoring, translation, and turnover. We report the initial characterization of a protein complex that binds RNA in a sequence-independent but size-dependent manner...
Ye Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(11), 4587-4598 (2015-03-20)
The structural microtubule-associated proteins (MAPs) are critical for the organization of neuronal microtubules (MTs). Microtubule-associated protein 1A (MAP1A) is one of the most abundantly expressed MAPs in the mammalian brain. However, its in vivo function remains largely unknown. Here we...
Cytoskeletons in the Closet-Subversion in Alphaherpesvirus Infections
Denes C, et al.
Viruses, 10(2), 79-79 (2018)
Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development
Hummel T, et al.
Neuron, 26(2), 357-370 (2000)
The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain
Douglas RM, et al.
Neuroscience, 139(4), 1249-1261 (2006)
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 51(6), 3019-3028 (2010-01-22)
To examine the time-dependent effects of focal axonal ischemia on the retinal ganglion cell (RGC) cytoskeleton. Eight pigs were used. Small retinal arteriolar branches were occluded by argon laser to induce focal ischemic insults that were maintained for a period...
David M Sherry et al.
BMC neuroscience, 14, 70-70 (2013-07-13)
Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac Exchanger 2 (P-Rex2) is a guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases, important regulators of actin cytoskeleton remodeling. P-Rex2 is known to modulate cerebellar Purkinje cell architecture and function, but P-Rex2 expression and function...
David M Sherry et al.
PloS one, 7(6), e39702-e39702 (2012-06-30)
To investigate the role(s) of protein-tyrosine sulfation in the retina and to determine the differential role(s) of tyrosylprotein sulfotransferases (TPST) 1 and 2 in vision, retinal function and structure were examined in mice lacking TPST-1 or TPST-2. Despite the normal...
Effect of intranasal administration of semliki forest virus recombinant particles expressing reporter and cytokine genes on the progression of experimental autoimmune encephalomyelitis
Jerusalmi A, et al.
Molecular Therapy, 8(6), 886-894 (2003)
C Balaratnasingam et al.
Neuroscience, 177, 269-282 (2011-01-11)
Oligodendrocyte-derived myelin retards the ability of CNS axons to regenerate following transection. The intrinsic response of CNS axons to an axotomy insult may be vastly different in the absence of myelin. However, the paucity of adequate experimental models has limited...
Deb Kumar Mojumder et al.
The Journal of physiology, 586(10), 2551-2580 (2008-04-05)
Voltage-gated sodium channels (Na(v) channels) in retinal neurons are known to contribute to the mammalian flash electroretinogram (ERG) via activity of third-order retinal neurons, i.e. amacrine and ganglion cells. This study investigated the effects of tetrodotoxin (TTX) blockade of Na(v)...
Ramon Velazquez et al.
Aging cell, 17(4), e12775-e12775 (2018-05-12)
Misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including Alzheimer's disease, frontotemporal dementia with Parkinsonism, corticobasal degeneration, progressive supranuclear palsy, Down syndrome, and Pick's disease. Tau is a microtubule-binding protein, and its role in microtubule stabilization is well defined....
Deb Kumar Mojumder et al.
Molecular vision, 14, 1600-1613 (2008-09-05)
Intracellular free calcium ions (Ca(2+)) are an important element in retinal ganglion cell response. Two major EF-hand (E-helix-loop-F-helix-hand) calcium binding proteins in the retina, calretinin and calbindin-28 kDa, are important buffers of intracellular free Ca(2+) in neurons, and may also...
G Huber et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 4(1), 151-160 (1984-01-01)
The distribution of microtubule-associated proteins (MAPs) 1 and 2 in rat brain was studied using monoclonal antibodies. Immunochemical staining showed that both MAP1 and MAP2 are present only in neurons and both are highly concentrated in dendrites compared to axons....
David M Sherry et al.
BMC neuroscience, 7, 54-54 (2006-07-15)
Syntaxins 1 through 4 are SNAP receptor (SNARE) proteins that mediate vesicular trafficking to the plasma membrane. In retina, syntaxins 1 and 3 are expressed at conventional and ribbon synapses, respectively, suggesting that synaptic trafficking functions differ among syntaxin isoforms....
A G Miriam Leenders et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(44), 11333-11346 (2008-10-31)
Ca(v)2.2 channels are localized at nerve terminals where they play a critical role in neurotransmission. However, the determinant that controls surface retention of these channels has not been identified. Here, we report that presynaptic surface localization of Ca(v)2.2 is mediated...
Alejandra Bosco et al.
The Journal of comparative neurology, 519(4), 599-620 (2011-01-20)
Changes in microglial cell activation and distribution are associated with neuronal decline in the central nervous system (CNS), particularly under pathological conditions. Activated microglia converge on the initial site of axonal degeneration in human glaucoma, yet their part in its...
Mark Rapoport et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(9), 6364-6369 (2002-04-18)
Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease, are the results of the pathological deposition of proteins normally present throughout the brain. Senile plaques are extracellular deposits of fibrillar beta-amyloid peptide (Abeta); neurofibrillary tangles represent intracellular...
Xiang-Ping Wang et al.
BMC molecular biology, 10, 109-109 (2009-12-17)
Cytoplasmic polyadenylation element binding proteins (CPEBs) regulate translation by binding to regulatory motifs of defined mRNA targets. This translational mechanism has been shown to play a critical role in oocyte maturation, early development, and memory formation in the hippocampus. Little...
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