Showing 1-10 of 10 resultados for "M6316"
Syoji Sakakibara et al.
Bioscience, biotechnology, and biochemistry, 74(5), 1055-1061 (2010-05-13)
This study examined the effect of acetate on endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) by immunoblotting assay and the ability of acetic acid to upregulate flow-mediated vasodilatation in humans. In HUVECs, acetate induced a...
[3H] MRS 1754, a selective antagonist radioligand for A2B adenosine receptors
Ji XD, et al.
Biochemical Pharmacology, 61(6), 657-663 (2001)
Nathaniel A Sowa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(31), 10282-10293 (2010-08-06)
Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons, functions as an ectonucleotidase, and generates adenosine extracellularly. Here, we found that PAP inhibits noxious thermal sensitivity and sensitization that is associated with chronic pain through sustained...
Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration
Rampon C, et al.
Purinergic Signaling, 10(4), 595-602 (2014)
X Ji et al.
Biochemical pharmacology, 61(6), 657-663 (2001-03-27)
MRS 1754 [N-(4-cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy]acetamide] is a selective antagonist ligand of A(2B) adenosine receptors. This is the least well-defined adenosine receptor subtype, and A(2B) antagonists have potential as antiasthmatic drugs. For use as a radioligand, MRS 1754, a p-cyanoanilide xanthine derivative, was...
Odailson Santos Paz et al.
European journal of medicinal chemistry, 136, 487-496 (2017-05-22)
Adenosine receptors are considered as potential targets for drug development against several diseases. The discovery of subtype 2B adenosine receptors role in erythrocyte sickling process proved its importance to neglected diseases such as sickle cell anemia, which affects approximately 29.000...
Laura Fontenas et al.
Cell reports, 27(1), 115-128 (2019-04-04)
During development, oligodendrocyte progenitor cells (OPCs) migrate extensively throughout the spinal cord. However, their migration is restricted at transition zones (TZs). At these specialized locations, unique glial cells in both zebrafish and mice play a role in preventing peripheral OPC...
Daniela Berenice Torres-Pineda et al.
Cytokine, 130, 155082-155082 (2020-04-08)
Cervical cancer (CeCa) produces large amounts of IL-10, which downregulates the major histocompatibility complex class I molecules (HLA-I) in cancer cells and inhibits the immune response mediated by cytotoxic T lymphocytes (CTLs). In this study, we analyzed the ability of...
Christine Rampon et al.
Purinergic signalling, 10(4), 595-602 (2014-08-03)
A major issue in regenerative medicine is the control of progenitor cell mobilisation. Apoptosis has been reported as playing a role in cell plasticity, and it has been recently shown that apoptosis is necessary for organ and appendage regeneration. In...
Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity
Sakakibara S, et al.
Bioscience, Biotechnology, and Biochemistry, 74(5), 1055-1061 (2010)

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