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Milton Thomas et al.
Viruses, 10(6) (2018-06-09)
Influenza viruses infect the epithelial cells of the swine respiratory tract. Cell lines derived from the respiratory tract of pigs could serve as an excellent in vitro model for studying the pathogenesis of influenza viruses. In this study, we examined
Lower levels of IgG1 in comparison with IgG2a are associated with protective immunity against Leishmania tropica infection in BALB/c mice.
Rostamian M, et al.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 50(2), 160-166 (2017)
Charlotta Böiers et al.
Developmental cell, 44(3), 362-377 (2018-01-02)
ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because lineage commitment hierarchies differ between embryo and adult, and the impact of oncogenes is cell-context dependent, we
R Djafarzadeh et al.
Oncogene, 25(10), 1496-1508 (2005-11-02)
The resistance of tumours to immune-mediated lysis has been linked to the biology of matrix metalloproteinases (MMPs), and specifically to the cell surface expression of MMPs by the tumour cell. The endogenous tissue inhibitors of metalloproteinases (TIMPs) exhibit diverse physiological/biological
Chithra C Sreenivasan et al.
Virology, 528, 152-163 (2019-01-08)
Influenza viruses are a group of respiratory pathogens that have evolved into four different types: A, B, C, and D. A common feature is that all four types are capable of replicating and transmitting among pigs. Here, we describe the
Louis-P Vézina et al.
Plant biotechnology journal, 7(5), 442-455 (2009-05-09)
Plant-based transient expression is potentially the most rapid and cost-efficient system for the production of recombinant pharmaceutical proteins, but safety concerns associated with plant-specific N-glycosylation have hampered its adoption as a commercial production system. In this article, we describe an
Hina Singh et al.
Journal of neuroinflammation, 17(1), 226-226 (2020-07-31)
HIV-1 infection remains a major public health concern despite effective combination antiretroviral therapy (cART). The virus enters the central nervous system (CNS) early in infection and continues to cause HIV-associated neurocognitive disorders (HAND). The pathogenic mechanisms of HIV-associated brain injury
Katarzyna Anna Mackenzie et al.
Histopathology, 58(6), 875-885 (2011-05-19)
The aim of this study was to determine the contribution of tumour angiogenesis to the aggressive growth of non-melanoma skin cancers (NMSCs) in renal transplant recipients (RTRs). The study cohort included RTRs (n = 38) with formalin-fixed paraffin-embedded tumour samples
Interaction sites on human IgG-Fc for FcgammaR: current models.
Jefferis R and Lund J
Immunology Letters, 82(1-2), 57-65 (2002)
Alexandra Krettek et al.
The American journal of pathology, 165(5), 1571-1581 (2004-10-29)
CD44, a polymorphic hyaluronate receptor, may participate in chronic inflammation. We hypothesized that CD44 variants contribute to the development of arterial diseases. CD44 levels vary in normal and diseased arterial tissues in the following order: unaffected arteries < fibrous plaques
Nicholas P Munro et al.
International journal of cancer, 119(11), 2642-2650 (2006-09-23)
Urinary biomarkers or profiles that allow noninvasive detection of recurrent transitional cell carcinoma (TCC) of the bladder are urgently needed. We obtained duplicate proteomic (SELDI) profiles from 227 subjects (118 TCC, 77 healthy controls and 32 controls with benign urological
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These
J A Roberts et al.
The European respiratory journal, 14(2), 275-282 (1999-10-09)
Salmeterol xinafoate is an inhaled long-acting beta2-adrenoceptor agonist recently introduced for the treatment of asthma. Both in vitro and animal studies suggest that it may have anti-inflammatory activities of benefit in this disease. To assess this directly, the effects of
M Matoug-Elwerfelli et al.
International endodontic journal, 51(6), 663-673 (2017-12-03)
To investigate the feasibility of decellularizing the entire dental pulp using a mild treatment protocol to develop a decellularized biological extracellular matrix scaffold for use in regenerative endodontic procedures. Decellularized human dental pulps were assessed using histological and immunohistochemical methods
Visceral tissue growth and proliferation during the bovine lactation cycle.
Baldwin RL, et al.
Journal of Dairy Science, 87(9), 2977-2986 (2004)
M Dellian et al.
British journal of cancer, 82(9), 1513-1518 (2000-05-02)
Molecular charge is one of the main determinants of transvascular transport. There are, however, no data available on the effect of molecular charge on microvascular permeability of macromolecules in solid tumours. To this end, we measured tumour microvascular permeability to
A V Popov et al.
The Journal of experimental medicine, 189(10), 1611-1620 (1999-05-20)
Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) lambda light (L) chain locus in germline configuration were created. The introduced translocus on a yeast artificial chromosome (YAC) accommodates the most proximal Iglambda variable region (V) gene cluster
The relative contribution of mast cell subsets to conjunctival TH2-like cytokines.
Anderson DF, et al.
Investigative Ophthalmology & Visual Science, 42(5), 995-1001 (2001)
Michele L Lokitz et al.
The Journal of investigative dermatology, 125(1), 166-173 (2005-06-29)
Mannose-binding lectin (MBL) is an integral part of the innate immune system and functions as an opsonin by binding to pathogens and certain apoptotic cells to promote their uptake by phagocytes. We recently identified an association of low-producing MBL polymorphisms
A Kantardzhieva et al.
Journal of proteome research, 11(2), 1163-1174 (2011-11-23)
The synaptic ribbon is an electron-dense structure found in hair cells and photoreceptors. The ribbon is surrounded by neurotransmitter-filled vesicles and considered to play a role in vesicle release. We generated an objective, quantitative analysis of the protein composition of
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.
Lee, et al.
Nature Biotechnology, 32, 356-363 (2018)
Ryuzaburo Yuki et al.
Oncogene, 38(5), 637-655 (2018-09-05)
Protein-tyrosine kinases regulate a broad range of intracellular processes occurring primarily just beneath the plasma membrane. With the greatest care to prevent dephosphorylation, we have shown that nuclear tyrosine phosphorylation regulates global chromatin structural states. However, the roles for tyrosine
Pratik Katwal et al.
Cytotechnology, 71(1), 127-148 (2019-01-03)
The intestinal epithelium is a major site of interaction with pathogens. In bovine intestinal epithelial cells (BIECs), Toll-like receptors (TLRs) play an important role in innate immune responses against enteric pathogens. This study is aimed at establishing a stable bovine
Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.
Hasan, et al.
Molecular Cell, 7, 1221-1231 (2019)
Michael J Herr et al.
PloS one, 9(9), e106999-e106999 (2014-09-04)
The most prevalent cardiovascular diseases arise from alterations in vascular smooth muscle cell (VSMC) morphology and function. Tetraspanin CD9 has been previously implicated in regulating vascular pathologies; however, insight into how CD9 may regulate adverse VSMC phenotypes has not been
IgG1 is required for optimal protection after immunization with the purified porin OmpD from Salmonella Typhimurium.
Zhang Y, et al.
Journal of Immunology, 199(12), 4103-4109 (2017)
S Hashira et al.
Pediatrics international : official journal of the Japan Pediatric Society, 42(4), 337-342 (2000-09-15)
Maternal immunoglobulin G (IgG), transferred across the placenta to the fetus during intrauterine life, is an important component of the neonatal immunological defence mechanisms against infection. There is controversy with respect to differences in placental transfer of the different IgG
Mariko Morii et al.
The Journal of biological chemistry, 292(5), 1648-1665 (2016-12-22)
Src-family tyrosine kinases are widely expressed in many cell types and participate in a variety of signal transduction pathways. Despite the significance of Src in suppression of apoptosis, its mechanism remains poorly understood. Here we show that Src acts as
G R Wayne Moore et al.
Journal of neuropathology and experimental neurology, 75(5), 415-428 (2016-03-21)
The choroid plexus (CP) provides a barrier to entry of toxic molecules from the blood into the brain and transports vital molecules into the cerebrospinal fluid. While a great deal is known about CP physiology, relatively little is known about
Cultured nasal polyps from nonatopic and atopic patients release RANTES spontaneously and after stimulation with phytohemagglutinin.
Teran, et al.
The Journal of Allergy and Clinical Immunology, 100, 499-504 (2019)
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