Showing 1-30 of 36 resultados for "MAB381"
Z Cai et al.
Brain research, 898(1), 126-135 (2001-04-09)
Chronic ischemic brain injuries were studied in 7- and 14-day-old rat pups, which were subjected to bilateral carotid artery occlusion (BCAO) on postnatal day 1. BCAO preferentially injured white matter in the corpus callosum, subcortex and internal capsule areas while...
NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes.
Chan, Jonah R, et al.
Neuron, 43, 183-191 (2004)
Junhua Xiao et al.
Neuro-Signals, 18(3), 186-202 (2011-01-19)
The extracellular factors that are responsible for inducing myelination in the central nervous system (CNS) remain elusive. We investigated whether brain-derived neurotrophic factor (BDNF) is implicated, by first confirming that BDNF heterozygous mice exhibit delayed CNS myelination during early postnatal...
Central Nervous System and Peripheral Expression of CCL19, CCL21 and Their Receptor CCR7 in Experimental Model of Multiple Sclerosis.
Bielecki, B; Jatczak-Pawlik, I; Wolinski, P; Bednarek, A; Glabinski, A
Archivum Immunologiae et Therapiae Experimentalis null
Junchao Qian et al.
Journal of neurotrauma, 27(3), 599-610 (2009-12-17)
Longitudinal in vivo proton magnetic resonance spectroscopy (1H-MRS) and immunohistochemistry were performed to investigate the tissue degeneration in traumatically injured rat spinal cord rostral and caudal to the lesion epicenter. On 1H-MRS significant decreases in N-acetyl aspartate (NAA) and total...
Andrew K Ottens et al.
Journal of neurochemistry, 104(5), 1404-1414 (2007-11-27)
Neurotrauma, as in the case of traumatic brain injury, promotes protease over-activation characterized by the select fragmentation of brain proteins. The resulting polypeptides are indicators of biochemical processes, which can be used to study post-injury dynamics and may also be...
Histological correlation of diffusion tensor imaging metrics in experimental spinal cord injury.
Juan J Herrera, Tessy Chacko, Ponnada A Narayana
Journal of Neuroscience Research null
Anti-myelin antibodies predict the clinical outcome after a first episode suggestive of MS.
V Tomassini, L De Giglio, M Reindl, P Russo, I Pestalozza, P Pantano, T Berger, C Pozzilli
Multiple Sclerosis (Houndmills, Basingstoke, England) null
Charly Abi Ghanem et al.
PLoS genetics, 13(11), e1007049-e1007049 (2017-11-07)
The oligodendrocyte density is greater and myelin sheaths are thicker in the adult male mouse brain when compared with females. Here, we show that these sex differences emerge during the first 10 postnatal days, precisely at a stage when a...
Yi Pang et al.
PloS one, 11(10), e0164403-e0164403 (2016-10-11)
Perinatal infection is a well-identified risk factor for a number of neurodevelopmental disorders, including brain white matter injury (WMI) and Autism Spectrum Disorders (ASD). The underlying mechanisms by which early life inflammatory events cause aberrant neural, cytoarchitectural, and network organization...
Jan Storek et al.
Clinical immunology (Orlando, Fla.), 113(3), 285-298 (2004-10-28)
To ascertain the consequences of severe leukopenia and the tempo of recovery, we studied the immunity of 56 adult patients treated for multiple sclerosis or systemic sclerosis with autologous CD34 cell transplantation using extremely lymphoablative conditioning. NK cell, monocyte, and...
Raymond A Sobel et al.
Journal of neuropathology and experimental neurology, 78(9), 819-843 (2019-08-11)
Using a panel of monoclonal antibodies (mAbs) to myelin proteolipid protein (PLP) peptides, we found that in addition to CNS myelin, mAbs to external face but not cytoplasmic face epitopes immunostained neurons in immature human CNS tissues and in adult...
Severe post-EBV encephalopathy associated with myelin oligodendrocyte glycoprotein-specific immune response.
Samantha Jilek, Jens Kuhle, Pascal Meylan, Marc D Reichhart, Giuseppe Pantaleo, Renaud A Du Pasquier
Journal of Neuroimmunology null
Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2.
Dolly A Padovani-Claudio, Liping Liu, Richard M Ransohoff, Robert H Miller
Glia null
V Draghi et al.
Scientific reports, 9(1), 10142-10142 (2019-07-14)
It is widely believed that rewarming slowly after therapeutic hypothermia for hypoxic-ischemic (HI) encephalopathy can improve outcomes, but its impact on white matter injury after HI is unclear. Fetal sheep (0.85 gestation) received 30 min ischemia-normothermia (n = 8), or hypothermia from 3-48 h...
Marylou V Solbrig et al.
Experimental neurology, 226(1), 231-241 (2010-09-14)
Chronic CNS infection by several families of viruses can produce deficits in prefrontal cortex (PFC) and striatal function. Cannabinoid drugs have been long known for their anti-inflammatory properties and their ability to modulate adult neuro and gliogenesis. Therefore, we explored...
Jens Kuhle et al.
The New England journal of medicine, 356(4), 371-378 (2007-01-26)
Patients with a single episode of neurologic dysfunction and brain magnetic resonance imaging (MRI) scans suggestive of multiple sclerosis are at high risk for clinically definite multiple sclerosis, but the outcome for individual patients is unpredictable. An increased risk of...
Junhua Xiao et al.
Journal of neurochemistry, 122(6), 1167-1180 (2012-07-13)
Multiple extracellular factors have been implicated in orchestrating myelination of the CNS; however, less is known about the intracellular signaling cascades that regulate this process. We have previously shown that brain-derived neurotrophic factor (BDNF) promotes oligodendrocyte myelination. Here, we screened...
Antimyelin antibodies in clinically isolated syndromes correlate with inflammation in MRI and CSF.
Jens Kuhle, Raija L P Lindberg, Axel Regeniter, Matthias Mehling, Francine Hoffmann et al.
Journal of Neurology null
Assessment of white matter injury following prolonged focal cerebral ischaemia in the rat.
E A Irving, D L Bentley, A A Parsons, E A Irving, D L Bentley, A A Parsons
Acta neuropathologica null
Lack of association between antimyelin antibodies and progression to multiple sclerosis.
Thomas Berger, Markus Reindl
The New England Journal of Medicine null
Expression of hemoglobin in rodent neurons.
Schelshorn, DW; Schneider, A; Kuschinsky, W; Weber, D; Kruger, C; Dittgen, T; Burgers et al.
Journal of Cerebral Blood Flow and Metabolism null
Lamia Bouslama-Oueghlani et al.
PloS one, 7(11), e49015-e49015 (2012-11-17)
Oligodendrocyte differentiation is temporally regulated during development by multiple factors. Here, we investigated whether the timing of oligodendrocyte differentiation might be controlled by neuronal differentiation in cerebellar organotypic cultures. In these cultures, the slices taken from newborn mice show very...
Satellite cells of dorsal root ganglia are multipotential glial precursors.
Svenningsen, Asa Fex, et al.
Neuron Glia Biology, 1, 85-93 (2004)
Recognition and degradation of myelin basic protein peptides by serum autoantibodies: novel biomarker for multiple sclerosis.
Alexey A Belogurov, Inna N Kurkova, Alain Friboulet, Daniel Thomas, Viktor K Misikov et al.
Journal of immunology (Baltimore, Md. : 1950) (1950)
Tyler A Kokjohn et al.
Journal of neurotrauma, 30(11), 981-997 (2012-12-28)
Dementia pugilistica (DP), a suite of neuropathological and cognitive function declines after chronic traumatic brain injury (TBI), is present in approximately 20% of retired boxers. Epidemiological studies indicate TBI is a risk factor for neurodegenerative disorders including Alzheimer disease (AD)...
Alistair E Govier-Cole et al.
eNeuro, 6(2) (2019-04-28)
Blocking inhibitory factors within CNS demyelinating lesions is regarded as a promising strategy to promote remyelination. Bone morphogenetic protein 4 (BMP4) is an inhibitory factor present in demyelinating lesions. Noggin, an endogenous antagonist to BMP, has previously been shown to...
Alex E Roher et al.
American journal of neurodegenerative disease, 2(3), 187-207 (2013-10-05)
Alzheimer's disease (AD) dementia impacts all facets of higher order cognitive function and is characterized by the presence of distinctive pathological lesions in the gray matter (GM). The profound alterations in GM structure and function have fostered the view that...
Neutrophil function and cytokine-specific signaling in chronic neutrophilic leukemia.
Y Uemura, T Taguchi, T Kubota, T Saito, K Bandobashi, A Yokoyama
International Journal of Laboratory Hematology null
Randa Sghaier et al.
Free radical research, 53(5), 535-561 (2019-05-02)
Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β-hydroxycholesterol (7β-OHC). It is, therefore, important to study the ability of 7β-OHC to trigger mitochondrial defects, oxidative stress, metabolic dysfunctions...

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