Showing 1-30 of 41 resultados for "OP03"
Jacob A Gordon et al.
Cancer research, 79(13), 3320-3331 (2019-05-09)
Aberrant cholesterol metabolism is increasingly appreciated to be essential for prostate cancer initiation and progression. Transcript expression of the high-density lipoprotein-cholesterol receptor scavenger receptor B1 (SR-B1) is elevated in primary prostate cancer. Hypothesizing that SR-B1 expression may help facilitate malignant...
R E Shackelford et al.
The Journal of biological chemistry, 276(24), 21951-21959 (2001-04-06)
Ataxia telangiectasia (AT) is an autosomal recessive disorder characterized by neuronal degeneration accompanied by ataxia, telangiectasias, acute cancer predisposition, and sensitivity to ionizing radiation (IR). Cells from individuals with AT show unusual sensitivity to IR, severely attenuated cell cycle checkpoint...
Chenghua Lou et al.
Oncology letters, 12(1), 295-300 (2016-06-28)
The present authors have recently demonstrated that hirsutine, one of the major alkaloids in Uncaria species, promotes cell apoptosis by inducing DNA damage and suppresses metastasis of breast cancer cells. Despite its potent anti-cancer activity, certain types of human breast...
Mitomycin C and doxorubicin elicit conflicting signals by causing accumulation of cyclin E prior to p21WAF1/CIP1 elevation in human hepatocellular carcinoma cells.
Choi, et al.
International Journal of Oncology, 40, 277-286 (2013)
Yuhei Mizunoe et al.
Autophagy, 13(4), 642-653 (2017-01-26)
Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in...
Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus.
Chiou, et al.
Journal of Virology, 67, 6201-6214 (2020)
Avijeet Chopra et al.
PloS one, 11(4), e0153818-e0153818 (2016-04-21)
Mitotic inhibitors are widely utilized chemotherapeutic agents that take advantage of mitotic defects in cancer cells. We have identified a novel class of piperazine-based mitotic inhibitors, of which AK301 is the most potent derivative identified to date (EC50 < 200...
Xun Jin et al.
Experimental & molecular medicine, 42(8), 574-582 (2010-07-16)
Although human telomerase catalytic subunit (TERT) has several cellular functions including telomere homeostasis, genomic stability, cell proliferation, and tumorigenesis, the molecular mechanism underlying anti-apoptosis regulated by TERT remains to be elucidated. Here, we show that ectopic expression of TERT in...
Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.
Valverde, AM; Mur, C; Brownlee, M; Benito, M
Molecular Biology of the Cell null
Terri J Harford et al.
Apoptosis : an international journal on programmed cell death, 22(12), 1532-1542 (2017-09-18)
The muscle regulatory transcription factor MyoD is a master regulator of skeletal myoblast differentiation. We have previously reported that MyoD is also necessary for the elevated expression of the pro-apoptotic Bcl2 family member PUMA, and the ensuing apoptosis, that occurs...
Yu-Mi Lim et al.
Nature communications, 5, 4934-4934 (2014-09-27)
Despite growing interest in the relationship between autophagy and systemic metabolism, how global changes in autophagy affect metabolism remains unclear. Here we show that mice with global haploinsufficiency of an essential autophagy gene (Atg7(+/-) mice) do not show metabolic abnormalities...
Thi T Nguyen et al.
Molecular and cellular biology, 25(6), 2147-2157 (2005-03-04)
We performed chromatin immunoprecipitation (ChIP) analyses of developmentally staged solid tissues isolated from wild-type and p53-null mice to determine specific histone N-terminal modifications, histone-modifying proteins, and transcription factor interactions at the developmental repressor region (-850) and core promoter of the...
Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells.
M??plan, et al.
The Journal of Biological Chemistry, 274, 31663-31670 (2021)
Ariel G Herman et al.
Cancer discovery, 1(4), 312-325 (2012-05-16)
E3 ubiquitin ligases are of interest as drug targets for their ability to regulate protein stability and function. The oncogene Mdm2 is an attractive E3 ligase to target, as it is the key negative regulator of the tumor suppressor p53...
D Escobar et al.
Cell death & disease, 6, e1816-e1816 (2015-07-17)
The Sall2 transcription factor is deregulated in several cancers; however, little is known about its cellular functions, including its target genes. Recently, we demonstrated that p53 directly regulates Sall2 expression under genotoxic stress. Here, we investigated the role of Sall2...
Laura Fozzatti et al.
PloS one, 8(6), e67954-e67954 (2013-07-11)
Studies have suggested that the nuclear receptor corepressor 1 (NCOR1) could play an important role in human cancers. However, the detailed molecular mechanisms by which it functions in vivo to affect cancer progression are not clear. The present study elucidated...
Rachel E Rempel et al.
Molecular cancer therapeutics, 13(12), 3219-3229 (2014-10-29)
Human aggressive B-cell non-Hodgkin lymphomas (NHL) encompass the continuum between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL), and display considerable clinical and biologic heterogeneity, most notably related to therapy response. We previously showed that lymphomas arising in the Eμ-Myc...
Ming Li et al.
Theranostics, 10(19), 8863-8879 (2020-08-06)
Background: As a histone demethylase, JMJD2D can enhance gene expression by specifically demethylating H3K9me2/3 and plays an important role in promoting colorectal cancer progression. However, its role in liver cancer remains unclear. Methods: The expression of JMJD2D was examined in...
Control of cell cycle progression by c-Jun is p53 dependent.
Schreiber, et al.
Genes & Development, 13, 607-619 (2019)
Kai Liu et al.
Molecular cell, 68(2), 281-292 (2017-10-17)
Autophagy is required for benign hepatic tumors to progress into malignant hepatocellular carcinoma. However, the mechanism is unclear. Here, we report that mitophagy, the selective removal of mitochondria by autophagy, positively regulates hepatic cancer stem cells (CSCs) by suppressing the...
Feijie Zhang et al.
American journal of respiratory cell and molecular biology, 31(6), 679-686 (2004-08-31)
Keratinocyte growth factor (KGF) is a mitogen for rat type II cells and also stimulates differentiation in vitro. Administration of KGF also protects the lung from a variety of injuries and subsequent development of fibrosis. Because transforming growth factor (TGF)-beta...
A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.
Rempel, et al.
PLoS Genetics, 5, e1000640-e1000640 (2018)
Toshiharu Komori et al.
Genes to cells : devoted to molecular & cellular mechanisms, 14(3), 343-354 (2009-02-13)
DSIF is an evolutionarily conserved, ubiquitously expressed, heterodimeric transcription elongation factor composed of two subunits, Spt4 and Spt5. Previous biochemical studies have shown that DSIF positively and negatively regulates RNA polymerase II elongation in collaboration with other protein factors. While...
Sara Gookin et al.
PLoS biology, 15(9), e2003268-e2003268 (2017-09-12)
The cell-cycle field has identified the core regulators that drive the cell cycle, but we do not have a clear map of the dynamics of these regulators during cell-cycle progression versus cell-cycle exit. Here we use single-cell time-lapse microscopy of...
Takeshi Yoshikawa et al.
PloS one, 8(9), e71969-e71969 (2013-09-12)
A widespread downregulated expression of microRNAs (miRNAs) is commonly observed in human cancers. Similarly, deregulated expression of miRNA-processing pathway components, which results in the reduction of global miRNA expression, may also be associated with tumorigenesis. Here, we show that specific...
Rosanna Beraldi et al.
Human molecular genetics, 24(22), 6473-6484 (2015-09-17)
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. AT is a neurodegenerative disease primarily characterized by cerebellar degeneration in children leading to motor impairment. The disease progresses with other clinical manifestations including...
Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response.
Bandhakavi, et al.
Molecular and Cellular Proteomics, 9, 403-414 (2021)
Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model.
Grippo, et al.
The American Journal of Pathology, 157, 805-813 (2018)

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