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Chenran Wang et al.
The Journal of cell biology, 216(8), 2581-2596 (2017-06-22)
Recent studies have shown important roles for autophagy genes in the regulation of different tissue stem cells, including neural stem/progenitor cells (NSCs). However, little is known about whether autophagy can regulate NSCs through cell-extrinsic mechanisms. Here, we show that deletion
Léanie Kleynhans et al.
PloS one, 6(9), e24639-e24639 (2011-09-21)
Most individuals latently infected with Mycobacterium tuberculosis (M.tb) contain the infection by a balance of effector and regulatory immune responses. This balance can be influenced by steroid hormones such as glucocorticoids. The widely used contraceptive medroxyprogesterone acetate (MPA) possesses glucocorticoid
Jung-Feng Lin et al.
International journal of molecular sciences, 20(21) (2019-10-28)
Chronic renal failure involving hemodialysis results in blood loss during filtration. Iron deficiency and iron deficiency anemia can result. A compensatory increase in iron dosage has many side effects including discomfort. Elemental iron is a highly-pure iron source, which reduces
Pranavi Koppula et al.
iScience, 24(6), 102649-102649 (2021-06-22)
Metabolic reprogramming in cancer cells can create metabolic liabilities. KEAP1-mutant lung cancer is refractory to most current therapies. Here we show that KEAP1 deficiency promotes glucose dependency in lung cancer cells, and KEAP1-mutant/deficient lung cancer cells are more vulnerable to
Karina M Lugo-Cintrón et al.
Lab on a chip, 20(9), 1586-1600 (2020-04-17)
Lymphatic vessels (LVs) have been suggested as a preferential conduit for metastatic progression in breast cancer, where a correlation between the occurrence of lymph node metastasis and an increased extracellular matrix (ECM) density has been reported. However, the effect of
Sylvie L Lesuis et al.
Biological psychiatry, 90(7), 494-504 (2021-09-11)
Traumatic experiences, such as conditioned threat, are coded as enduring memories that are frequently subject to generalization, which is characterized by (re-) expression of fear in safe environments. However, the neurobiological mechanisms underlying threat generalization after a traumatic experience and
Severa Bunda et al.
Nature communications, 10(1), 661-661 (2019-02-10)
Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC is mutated in other tumors
Emilie Viennois et al.
Cell reports, 33(1), 108229-108229 (2020-10-08)
Dietary emulsifiers carboxymethylcellulose (CMC) and polysorbate-80 (P80) disturb gut microbiota, promoting chronic inflammation. Mice with minimal microbiota are protected against emulsifiers' effects, leading us to hypothesize that these compounds might provoke select pathobionts to promote inflammation. Gnotobiotic wild-type (WT) and
R J Katz et al.
Pharmacology, biochemistry, and behavior, 5(4), 391-394 (1976-10-01)
Previous investigations of the effects of parachlorophenylalanine (PCPA) on affective attack have produced equivocal results. The present report examined the effects of PCPA upon attack elicited by electrical stimulation of the ventromedial hypothalamic nucleus in the cat. Using a within-animals
Maurizio Bettiga et al.
Biotechnology for biofuels, 1(1), 16-16 (2008-10-25)
Ethanolic fermentation of lignocellulosic biomass is a sustainable option for the production of bioethanol. This process would greatly benefit from recombinant Saccharomyces cerevisiae strains also able to ferment, besides the hexose sugar fraction, the pentose sugars, arabinose and xylose. Different
Rafaela C Sartore et al.
PloS one, 6(6), e20667-e20667 (2011-06-16)
The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate
Matthew F Wipperman et al.
Molecular cell, 72(1), 152-161 (2018-09-04)
Infection with Mycobacterium tuberculosis continues to cause substantial human mortality, in part because of the emergence of antimicrobial resistance. Antimicrobial resistance in tuberculosis is solely the result of chromosomal mutations that modify drug activators or targets, yet the mechanisms controlling
Mohammed O Altonsy et al.
Immunity, inflammation and disease, 8(1), 62-79 (2020-01-09)
Corynebacterium tuberculostearicum (C. t.) is a ubiquitous bacterium that colonizes human skin. In contrast to other members of the genus Corynebacterium, such as toxigenic Corynebacterium diphtheriae or the opportunistic pathogen Corynebacterium jeikeium, several studies suggest that C. t. may play
Zandra Gerdes et al.
PloS one, 14(2), e0205378-e0205378 (2019-02-20)
The role of microplastic (MP) as a carrier of persistent organic pollutants (POPs) to aquatic organisms has been a topic of debate. However, the reverse POP transport can occur if relative contaminant concentrations are higher in the organism than in
Audrey Bernut et al.
Cell reports, 26(7), 1828-1840 (2019-02-14)
Infection by rapidly growing Mycobacterium abscessus is increasingly prevalent in cystic fibrosis (CF), a genetic disease caused by a defective CF transmembrane conductance regulator (CFTR). However, the potential link between a dysfunctional CFTR and vulnerability to M. abscessus infection remains unknown.
Bi-Sen Ding et al.
Developmental cell, 53(6), 677-690 (2020-06-17)
Here, we show that the liver-derived apolipoprotein M (ApoM) protects the lung and kidney from pro-fibrotic insults and that this circulating factor is attenuated in aged mice. Aged mouse hepatocytes exhibit transcriptional suppression of ApoM. This leads to reduced sphingosine-1-phosphate
Syed A Sattar et al.
PloS one, 6(2), e17340-e17340 (2011-03-11)
Human noroviruses (HuNoV), a major cause of acute gastroenteritis worldwide, cannot be readily cultured in the lab. Therefore, a feline calicivirus (FCV) is often used as its surrogate to, among other things, test alcohol-based handrubs (ABHR). The more recent laboratory
Victor Ryu et al.
Journal of colloid and interface science, 556, 568-576 (2019-09-04)
The objective of this study was to provide insights into the mechanisms involved in the mass transport of antimicrobial compounds from essential oil nanoemulsions to bacterial cell membranes. Origanum oil-in-water nanoemulsions were produced using spontaneous emulsification by titrating a mixture
Sabrina Rizzolio et al.
The Journal of clinical investigation, 128(9), 3976-3990 (2018-06-29)
Cancer cell dependence on activated oncogenes is therapeutically targeted, but acquired resistance is virtually unavoidable. Here we show that the treatment of addicted melanoma cells with BRAF inhibitors, and of breast cancer cells with HER2-targeted drugs, led to an adaptive
Esther Visser et al.
Science advances, 6(19), eaax7060-eaax7060 (2020-06-05)
Alcohol use disorder is characterized by a high risk of relapse during periods of abstinence. Relapse is often triggered by retrieval of persistent alcohol memories upon exposure to alcohol-associated environmental cues, but little is known about the neuronal circuitry that
Nayef Mazloum et al.
Biochemistry, 50(8), 1329-1335 (2011-01-18)
Bacterial DNA can be damaged by reactive nitrogen and oxygen intermediates (RNI and ROI) generated by host immunity, as well as by antibiotics that trigger bacterial production of ROI. Thus a pathogen's ability to repair its DNA may be important
Handbook of Biochemistry and Molecular Biology (2010)
T L Buhr et al.
Journal of applied microbiology, 128(1), 124-137 (2019-10-02)
To add a spore germination step in order to reduce decontamination temperature and time requirements compared to the current hot, humid air decontamination parameters, which are 75-80°C, ≥72 h, 70-90% RH, down to ≤60°C and ≤24 h total decontamination time. Bacillus anthracis
Soo Yeon Kim et al.
Autophagy, 14(1), 152-168 (2017-08-26)
The orphan nuclear receptor ESRRA (estrogen-related receptor α) is a key regulator of energy homeostasis and mitochondrial function. Macroautophagy/autophagy, an intracellular degradation process, is a critical innate effector against intracellular microbes. Here, we demonstrate that ESRRA is required for the
Hamed Mosaei et al.
Molecular cell, 72(2), 263-274 (2018-09-25)
Antibiotic-resistant bacterial pathogens pose an urgent healthcare threat, prompting a demand for new medicines. We report the mode of action of the natural ansamycin antibiotic kanglemycin A (KglA). KglA binds bacterial RNA polymerase at the rifampicin-binding pocket but maintains potency
Da-Hye Lee et al.
Autophagy, 17(9), 2415-2431 (2020-10-21)
Macroautophagy/autophagy, a self-degradative process, regulates metabolic homeostasis in response to various stress conditions and is a therapeutic target for nonalcoholic fatty liver disease. We found that autophagic activity was inhibited as a result of a significant reduction in the expression
Valeria da Silva Santos et al.
Food chemistry, 298, 125053-125053 (2019-07-02)
The objective of this study was to develop nanostructured lipid carriers (NLCs) with free phytosterols (FP) using conventional fats and oils. Lipid matrices (LMs) and NLCs were produced with high oleic sunflower oil, fully hydrogenated canola (CA) and crambe (CR)
Syn Kok Yeo et al.
Autophagy, 14(7), 1214-1225 (2018-06-26)
Breast cancer is a heterogeneous disease, and stratification of patients is fundamental to the success of treatment modalities. Breast tumors deficient in BRCA1 are mostly associated with basal-like breast cancers and targeted therapeutics for this disease subtype are still lacking.
Md Munir Mostafiz et al.
Ecotoxicology and environmental safety, 184, 109653-109653 (2019-09-19)
Plant-derived benzoates are known to have insecticidal and repellent activities, however, these effects have been evaluated thoroughly in only a few groups of insects. In this study, the insecticidal activities of three commercially available benzoates, methyl benzoate (MB), ethyl benzoate
Zhenzhen Chen et al.
Parasites & vectors, 12(1), 425-425 (2019-08-30)
Treatment of Psoroptes ovis in cattle is limited to topical acaricides or systemic treatment with macrocyclic lactones. Treatment failure of macrocyclic lactones has been reported. The aim of this study was to evaluate a potential alternative treatment against P. ovis.
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