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H Cao et al.
European review for medical and pharmacological sciences, 17(11), 1427-1437 (2013-06-19)
Recently, type II collagen (CII) was found to be effective clinically for treatment of rheumatoid arthritis (RA). However, the molecular properties of CII could be changed during the preparation process. In the present study, we isolated CII from chick sternal
Chanchan Sun et al.
Food & function, 9(9), 4683-4694 (2018-08-10)
Since lipid digestion is an interfacial process, food emulsions are increasingly being seen as a mechanism for controlling lipid uptake. Oil-in-water emulsions stabilized by whey protein (WP) and protein-xanthan gum (XG) mixtures were designed to investigate the influence of interfacial
Soojin Lee et al.
International journal of molecular sciences, 22(6) (2021-04-04)
A flexible and bioactive scaffold for adipose tissue engineering was fabricated and evaluated by dual nozzle three-dimensional printing. A highly elastic poly (L-lactide-co-ε-caprolactone) (PLCL) copolymer, which acted as the main scaffolding, and human adipose tissue derived decellularized extracellular matrix (dECM)
Ziyu Zhang et al.
Journal of the science of food and agriculture, 101(3), 871-879 (2020-07-31)
The aim of this study was to investigate the effect of lactic fermentation on soy protein gastrointestinal digestive pattern and the influence of protein digesta on human faecal microbiota. Soymilk and soy yogurt were prepared in this study and a
Noor Akmal Syed Husain Sharifah et al.
Methods in molecular biology (Clifton, N.J.), 952, 187-196 (2012-10-27)
Fluorescence in situ hybridization (FISH) is increasingly gaining importance in clinical diagnostics settings. Due to the ability of the technique to detect chromosomal abnormalities in samples with low cellularity or containing a mixed population of cells even at a single-cell
Yihui Wang et al.
Journal of agricultural and food chemistry, 67(8), 2296-2306 (2019-02-06)
The protein corona (PC), which defines the biological identity of nanoparticles in the blood, is well-known, but no comprehensive and systematic study has been conducted yet on the formation of PCs in the gastrointestinal environment. Thus, this study aimed to
Sophia P Pilipchuk et al.
Journal of biomedical materials research. Part A, 101(10), 2883-2895 (2013-03-19)
Natural hydrogels have been investigated for three-dimensional tissue reconstruction and regeneration given their ability to emulate the structural complexity of multi-component extracellular matrices (ECM). Hydrogels rich in ECM can be extracted and assembled from soft tissues, retain a composition specific
Marilyn Schallom et al.
American journal of critical care : an official publication, American Association of Critical-Care Nurses, 22(5), 408-411 (2013-09-03)
Because reflux of gastric juice into the oropharynx must precede its aspiration into the lungs, it is reasonable to hypothesize that the detection of pepsin (the major gastric enzyme in gastric juice) in oral secretions may provide a relatively noninvasive
Mikael Lenz Strube et al.
Applied and environmental microbiology, 81(5), 1668-1678 (2014-12-21)
Postweaning diarrhea (PWD) in pigs is a leading cause of economic loss in pork production worldwide. The current practice of using antibiotics and zinc to treat PWD is unsustainable due to the potential of antibiotic resistance and ecological disturbance, and
Joycelyn K Quansah et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 68(1), 31-38 (2013-01-29)
The effect of thermal and ultrasonic treatment of cowpea proteins (CP) on amino acid composition, radical scavenging and reducing potential of hydrolysates (CPH) obtained from in vitro simulated gastrointestinal digestion of CP was evaluated. Hydrolysis of native and treated CP
Mahmoud-Awny Magdy et al.
European journal of pharmacology, 697(1-3), 126-131 (2012-10-12)
Ample of evidence proved the gastroprotective effect of thymoquinone (TQ), the main constituent of Nigella sativa oil; however, the full mechanistic cassette on the gastric ulcer etiopathogenesis is not fully elucidated. The aim of the present work is to unveil
J Pohl et al.
Biochemistry, 27(13), 4827-4834 (1988-06-28)
The possibility that pig pepsin has a cation binding specificity in its secondary binding subsites has been examined by the pepsin-catalyzed hydrolysis of a series of synthetic octa- to undecapeptide substrates. These chromophoric substrates are cleaved by pepsin in the
Shenlin Wang et al.
The Journal of biological chemistry, 289(2), 697-707 (2013-11-23)
Multidomain protein folding is often more complex than a two-state process, which leads to the spontaneous folding of the native state. Pepsin, a zymogen-derived enzyme, without its prosegment (PS), is irreversibly denatured and folds to a thermodynamically stable, non-native conformation
D Wang et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 83(3-4), 179-189 (2008-10-11)
Angiogenesis, or neovascularization, is known to play an important role in the neoplastic progression leading to metastasis. CD31 or Factor VIII-related antigen (F VIII RAg) immunohistochemistry is widely used in experimental studies for quantifying tumor neovascularization in immunocompromised animal models
[The role of hydrochloric acid and pepsin in the etiology of peptic ulcer].
T Mach
Przeglad lekarski, 52(1), 19-21 (1995-01-01)
J Kyle Bohman et al.
Chest, 143(5), 1407-1413 (2012-11-03)
Airway pepsin has been increasingly used as a potentially sensitive and quantifiable biomarker for gastric-to-pulmonary aspiration, despite lack of validation in normal control subjects. This study attempts to define normal levels of airway pepsin in adults and distinguish between pepsin
Stephen R Haines et al.
BMC complementary and alternative medicine, 19(1), 350-350 (2019-12-07)
The use of deer velvet antler (DVA) as a potent traditional medicine ingredient goes back for over 2000 years in Asia. Increasingly, though, DVA is being included as a high protein functional food ingredient in convenient, ready to consume products in
Elizabeth A Kelly et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(4), 618-624 (2014-01-01)
(1) Investigate the role of reflux, specifically pepsin, in laryngopharyngeal carcinogenesis. (2) Evaluate effects of chronic pepsin exposure on cell migration, apoptosis, and colony-forming ability in hypopharyngeal cells. Translation research. Academic research laboratory. Human hypopharyngeal squamous carcinoma FaDu cells were
Shibu Chameettachal et al.
ACS applied bio materials, 4(1), 533-544 (2022-01-12)
Corneal scarring is one of the major causes of blindness, affecting millions worldwide. Despite recent advancements in surgical strategies, there is an unmet need for a clinically feasible material and methods to prevent scarring following corneal injury. In this study
Testing for laryngopharyngeal reflux in exhaled breath condensate: a pilot study.
C R Davies-Husband et al.
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 37(6), 497-498 (2012-12-21)
R A Rocha et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 59, 104-110 (2013-06-12)
Fluoride is considered important for health because of its beneficial effect on the prevention of dental caries and on bone development in the child population. However, excessive intake has negative effects. The main pathway for exposure is oral, through consumption
Moushree Pal Roy et al.
Indian journal of biochemistry & biophysics, 49(4), 266-271 (2012-10-20)
Phytases catalyze the release of phosphate from phytic acid. In this study, a phytase producing bacterial strain Shigella sp. CD2 was isolated from the wheat rhizosphere. Phytase production started from the exponential phase of bacterial growth, showing the highest activity
Sergiu Cecoltan et al.
Frontiers in cardiovascular medicine, 8, 714573-714573 (2021-08-31)
Background: Valvular endothelial cells (VEC) have key roles in maintaining valvular integrity and homeostasis, and dysfunctional VEC are the initiators and major contributors to aortic valve disease in diabetes. Previous studies have shown that HG stimulated an inflammatory phenotype in
J Tack
Alimentary pharmacology & therapeutics, 22 Suppl 1, 48-54 (2005-07-27)
Gastro-oesophageal reflux disease is defined as the presence of symptoms or lesions that can be attributed to the reflux of gastric contents into the oesophagus. Aspiration and prolonged monitoring studies in humans have shown that reflux of gastric contents is
J R Knowles et al.
The Biochemical journal, 113(2), 343-351 (1969-06-01)
1. The pH-dependence of the binding to pepsin of four dipeptide competitive inhibitors is reported. Values of K(i) obtained from equilibrium-dialysis experiments agree closely with those from kinetic measurements. 2. The binding of uncharged N-acyl-dipeptide amides to pepsin is essentially
Alexandre Minami Fioroto et al.
Journal of agricultural and food chemistry, 63(28), 6331-6337 (2015-07-03)
In vitro gastrointestinal digestion of babassu mesocarp in the absence and presence of milk and lignin was performed to evaluate the bioaccessibility of Cu, Fe, and Zn. Extractions using NaOH solutions (pH 7 and 12) were carried out to evaluate
Jon Alberdi-Cedeño et al.
Antioxidants (Basel, Switzerland), 9(4) (2020-04-25)
The effect of enriching virgin flaxseed oil with dodecyl gallate, hydroxytyrosol acetate or gamma-tocopherol on its in vitro digestion is studied by means of proton nuclear magnetic resonance and solid phase microextraction followed by gas chromatography/mass spectrometry. The extent and
Shuting Qing et al.
Food & function, 10(12), 7855-7864 (2019-11-22)
This study was designed to compare the effects of different satiety levels on the digestion and antigenicity of soymilk protein. The DIVRSD-II dynamic in vitro digestion model (DIVD) was employed to simulate different satiety degrees by changing the amount of
Tiantian Lin et al.
Food chemistry, 310, 125699-125699 (2019-12-08)
The capacity of high-fiber foods to sequester BS during digestion is considered a mechanism to lower serum-cholesterol. We investigated the effect of hydrothermal (HT) and high-hydrostatic-pressure (HHP) on the bile salt (BS)-binding ability of dry beans, and how this relates
Qiang Zou et al.
Journal of food science, 77(5), M270-M277 (2012-11-21)
Bifidobacterium bifidum F-35 was microencapsulated into whey protein microcapsules (WPMs) by a transglutaminase (TGase)-induced method after optimization of gelation conditions. The performance of these WPMs was compared with that produced by a spray drying method (WPMs-A). WPMs produced by the
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