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Sara M Villani et al.
Phytopathology, 104(9), 945-953 (2014-03-15)
Quantitative (partial) and qualitative (complete) resistance responses to quinone outside inhibitor (QoI) fungicides have been documented for the apple scab pathogen Venturia inaequalis. Resistance monitoring efforts have traditionally focused on the detection of qualitative resistance based on a single point
Maria Teresa Montagna et al.
Journal of medical microbiology, 63(Pt 12), 1638-1643 (2014-09-12)
We determined the in vitro antifungal activity of liposomal amphotericin B (L-AmB) against 604 clinical yeast isolates. Amphotericin B deoxycholate (D-AmB) was tested in parallel against all the isolates. Susceptibility testing was performed according to the Clinical and Laboratory Standards
Raiyan T Zaman et al.
PloS one, 9(9), e108108-e108108 (2014-09-19)
Atherosclerosis is a progressive inflammatory condition that underlies coronary artery disease (CAD)-the leading cause of death in the United States. Thus, the ultimate goal of this research is to advance our understanding of human CAD by improving the characterization of
Louise S Dalbøge et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 353-360 (2014-06-07)
Antidiabetic treatments aiming to preserve or even to increase β-cell mass are currently gaining increased interest. Here we investigated the effect of chronic treatment with the novel glucagon-like peptide-1 (GLP-1)-gastrin dual agonist ZP3022 (HGEGTFTSDLSKQMEEEAVRLFIEWLKN-8Ado-8Ado-YGWLDF-NH2) on glycemic control, β-cell mass and
Vijayashankar Nataraj et al.
PloS one, 10(3), e0122804-e0122804 (2015-04-22)
Lipooligosaccharides are glycolipids found in the cell wall of many mycobacterial species including the opportunistic pathogen Mycobacterium kansasii. The genome of M. kansasii ATCC12478 contains a cluster with genes orthologous to Mycobacterium marinum LOS biosynthesis genes. To initiate a genetic
Kim Tardif et al.
Cardiovascular diabetology, 13, 119-119 (2014-08-21)
Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following
Edward T Wargent et al.
PeerJ, 3, e753-e753 (2015-02-24)
The literature is unclear on whether the adipokine chemerin has pro- or anti-inflammatory properties or plays any role in the aetiology of type 2 diabetes or obesity. To address these questions, and in particular the potential of agonists or antagonists
Fengqin Yang et al.
Journal of ethnopharmacology, 163, 88-93 (2015-01-28)
A series of 40 important Traditional Chinese Medicines (TCMs), which were reported effective in treating superficial fungal infections of the skin in Chinese clinical trial publications and Chinese Herbal Classics, were chosen for the investigation of the individual and combination
Roupen Hatzakorzian et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(11), 1380-1387 (2014-09-27)
We investigated the effect of insulin administered as part of a hyperinsulinemic-normoglycemic clamp on protein metabolism after coronary artery bypass grafting (CABG) surgery. Eighteen patients were studied, with nine patients in the control group receiving standard metabolic care and nine
Beng Fye Lau et al.
PloS one, 9(7), e102509-e102509 (2014-07-24)
Previous studies on the nutritional and nutraceutical properties of Lignosus rhinocerotis focused mainly on the sclerotium; however, the supply of wild sclerotium is limited. In this investigation, the antioxidant capacity and cytotoxic effect of L. rhinocerotis cultured under different conditions
Hao Wang et al.
The journal of trauma and acute care surgery, 77(6), 926-933 (2014-09-24)
Hemorrhagic shock (HS) may contribute to organ failure, by profoundly altering mitochondrial function. Resveratrol (RSV), a naturally occurring polyphenol, has been shown to promote mitochondrial function and regulate glucose homeostasis in diabetes. We hypothesized that RSV during resuscitation would ameliorate
X Zhao et al.
International journal of molecular medicine, 35(3), 684-692 (2015-01-13)
Tubular atrophy and dysfunction is a critical process underlying diabetic nephropathy (DN). Understanding the mechanisms underlying renal tubular epithelial cell survival is important for the prevention of kidney failure associated with glucotoxicity. Autophagy is a cellular pathway involved in protein
Sangkyu Park et al.
PloS one, 9(10), e109453-e109453 (2014-10-07)
Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol level and lesion size in fruits infected with Colletotrichum gloeosporioides, depending on the stage
Neha Kaushik et al.
Scientific reports, 5, 8726-8726 (2015-03-05)
In this study, we show the selective and efficient anti-cancer effects of plasma (at a low dose) when cell metabolic modifiers are also included. 2-deoxy-D-glucose (2-DG), a glycolytic inhibitor, was used with effective doses of non-thermal plasma, synergistically attenuating cell
Panida Thanyasrisung et al.
Journal of medical microbiology, 63(Pt 5), 753-759 (2014-03-05)
Oral candidiasis is a common opportunistic infection among human immunodeficiency virus (HIV)-infected individuals, with growing concerns about the emergence of non-albicans species with resistance to antifungal agents. This cross-sectional study determined the prevalence of oral Candida species in Thai HIV-infected
L H Vähätalo et al.
Acta physiologica (Oxford, England), 213(4), 902-919 (2014-12-09)
Neuropeptide Y (NPY) co-localized with noradrenaline in central and sympathetic nervous systems seems to play a role in the control of energy metabolism. In this study, the aim was to elucidate the effects and pathophysiological mechanisms of increased NPY in
V Pathak et al.
Molecular and cellular endocrinology, 401, 120-129 (2014-12-03)
Compromise of gastric inhibitory polypeptide (GIP) receptor signalling represents a possible therapeutic strategy for the treatment of obesity-related diabetes. This study has characterised and evaluated the C-terminally fatty acid derivatised GIP analogues, GIP(3-30)Cex-K(40)[Pal] and Pro(3)GIP(3-30)Cex-K(40)[Pal], as potential GIP inhibitors. Both
Adam D Richardson et al.
Breast cancer research and treatment, 110(2), 297-307 (2007-09-20)
There is a growing belief that the metabolic program of breast tumor cells could be a therapeutic target. Yet, without detailed information on central carbon metabolism in breast tumors it is impossible to know which metabolic pathways to target, and
M A Bartlomiejczyk et al.
Clinical and experimental immunology, 178(2), 310-319 (2014-07-22)
We have demonstrated that mannose-binding lectin (MBL) recognizes various slow-growing, pathogenic mycobacteria [Mycobacterium tuberculosis (MTB), M. bovis, M. kansasii, M. gordonae] as well as non-pathogenic M. smegmatis. Recognition resulted in activation of the lectin pathway (LP) of complement and an enhancement of phagocytosis (shown for
Yasuo Uchida et al.
Drug metabolism and pharmacokinetics, 30(2), 205-208 (2015-03-15)
The purpose of the present study was to evaluate and compare the absolute protein expression levels of 28 drug-related transporters in Caco-2 cell monolayers cultured for 2, 3, and 4 weeks. Plasma membrane fractions of Caco-2 cells cultured on Transwell
Yoshiharu Matsumae et al.
Analytica chimica acta, 842, 20-26 (2014-08-17)
We evaluated the intracellular quinone oxidoreductase (NQO) activity of single HeLa cells by using the menadione-ferrocyanide double-mediator system combined with scanning electrochemical microscopy (SECM). The double-mediator system was used to amplify the current response from the intracellular NQO activity and
Mahdy Ranjbar et al.
Ophthalmic research, 53(3), 136-140 (2015-02-28)
Disease-modifying antirheumatic drugs (DMARDs) have been suggested in the treatment of inflammatory ophthalmological diseases. The aim of the present study was to investigate the effects of these DMARDs on bovine retinal function. Bovine retina preparations were perfused with a standard
Jeanette C Perron et al.
Neural development, 6, 36-36 (2011-11-17)
Bone morphogenetic protein (BMP)7 evokes both inductive and axon orienting responses in dorsal interneurons (dI neurons) in the developing spinal cord. These events occur sequentially during the development of spinal neurons but in these and other cell types such inductive
Alejo Efeyan et al.
Nature, 517(7534), 302-310 (2015-01-17)
The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels
Vincent C Luca et al.
Science (New York, N.Y.), 347(6224), 847-853 (2015-02-24)
Notch receptors guide mammalian cell fate decisions by engaging the proteins Jagged and Delta-like (DLL). The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Steven K Pregizer et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 64-70 (2014-07-22)
Transcription of BMPs and their antagonists in precise spatiotemporal patterns is essential for proper skeletal development, maturation, maintenance, and repair. Nevertheless, transcriptional activity of these molecules in skeletal tissues beyond embryogenesis has not been well characterized. In this study, we
Diego F Garcia-Diaz et al.
Journal of medicinal food, 18(4), 489-496 (2014-08-01)
Increased adiposity has been associated with macrophage infiltration into the adipose tissue which, in turn, leads to obesity comorbidities, including type 2 diabetes. The objective of this study was to evaluate the effect of anthocyanin (ANC)-enriched fractions from blackberry-blueberry beverages
Deborah M Muoio
Cell, 159(6), 1253-1262 (2014-12-07)
Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation, as the mitochondrial machinery responsible for carbon combustion switches freely between alternative fuels according to physiological and nutritional circumstances. These transitions in fuel choice are orchestrated by
Karl Herholz
Expert review of neurotherapeutics, 10(11), 1667-1673 (2010-10-28)
Assessment of regional cerebral glucose metabolism by (18)F-2-fluoro-2-deoxy-D-glucose (FDG)-PET at resting state is a standard functional technique to assess cerebral function. Group studies identified significant regional metabolic impairment in asymptomatic individuals at increased risk for dementia. Substantial impairment of FDG
Maria Luisa Rojo et al.
Life sciences, 108(2), 116-121 (2014-06-15)
A high consumption of fructose leads not only to peripheral changes in insulin sensitivity and vascular function, but also to central changes in several brain regions. Given the role of the endogenous cannabinoid system in the control of energy intake
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