Showing 1-11 of 11 resultados for "S1073"
Chang-He Shi et al.
Human molecular genetics, 23(4), 1013-1024 (2013-10-12)
Gordon Holmes syndrome (GHS) is a rare Mendelian neurodegenerative disorder characterized by ataxia and hypogonadism. Recently, it was suggested that disordered ubiquitination underlies GHS though the discovery of exome mutations in the E3 ligase RNF216 and deubiquitinase OTUD4. We performed...
Mai Tsuchiya et al.
Biochemical and biophysical research communications, 452(4), 928-932 (2014-09-23)
Cancer stem cells (CSCs) have several distinctive characteristics, including high metastatic potential, tumor-initiating potential, and properties that resemble normal stem cells such as self-renewal, differentiation, and drug efflux. Because of these characteristics, CSC is regarded to be responsible for cancer...
J Jiang et al.
The Journal of biological chemistry, 276(46), 42938-42944 (2001-09-15)
Proper folding of proteins (either newly synthesized or damaged in response to a stressful event) occurs in a highly regulated fashion. Cytosolic chaperones such as Hsc/Hsp70 are assisted by cofactors that modulate the folding machinery in a positive or negative...
Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP
Shi CH, et al.
Human Molecular Genetics, 23(4), 1013-1024 (2013)
CHIP Knockdown Reduced Heat Shock Response and Protein Quality Control Capacity in Lens Epithelial Cells
Zhang W, et al.
Current Molecular Medicine, 15(7), 652-662 (2015)
Chang-He Shi et al.
PLoS genetics, 14(9), e1007664-e1007664 (2018-09-18)
CHIP (carboxyl terminus of heat shock 70-interacting protein) has long been recognized as an active member of the cellular protein quality control system given the ability of CHIP to function as both a co-chaperone and ubiquitin ligase. We discovered a...
CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha
Fan M, et al.
Molecular Endocrinology, 19(12), 2901-2914 (2005)
F Bertucci et al.
Oncogene, 27(40), 5359-5372 (2008-05-21)
Invasive ductal carcinomas (IDCs) and invasive lobular carcinomas (ILCs) are the two major pathological types of breast cancer. Epidemiological and histoclinical data suggest biological differences, but little is known about the molecular alterations involved in ILCs. We undertook a comparative...
Regulation of autophagic flux by CHIP
Guo D, et al.
Neuroscience Bulletin, 31(4), 469-479 (2015)
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Izumi Horikawa et al.
Nature communications, 5, 4706-4706 (2014-08-22)
Δ133p53α, a p53 isoform that can inhibit full-length p53, is downregulated at replicative senescence in a manner independent of mRNA regulation and proteasome-mediated degradation. Here we demonstrate that, unlike full-length p53, Δ133p53α is degraded by autophagy during replicative senescence. Pharmacological...

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