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Kulthida Vaeteewoottacharn et al.
Anticancer research, 34(4), 1865-1871 (2014-04-03)
Primary effusion lymphoma (PEL) is a rare but aggressive form of non-Hodgkin's B-cell lymphoma in immunodeficient patients. Resistance to conventional chemotherapeutic regimens is common in PEL and contributes to a very poor prognosis; hence, novel potent anti-PEL agents are required.
Jos J Eggermont
Hearing research, 295, 140-149 (2012-02-15)
Animal models of tinnitus require a behavioral correlate thereof. Various conditioned response methods and gap-startle reflex methods are in use and the outcomes generally correspond with putative electrophysiological substrates of tinnitus. However, for salicylate-induced tinnitus there is discordance between the
Nina Kammerhofer et al.
The New phytologist, 207(3), 778-789 (2015-04-01)
Heterodera schachtii, a plant-parasitic cyst nematode, invades host roots and induces a specific syncytial feeding structure, from which it withdraws all required nutrients, causing severe yield losses. The system H. schachtii-Arabidopsis is an excellent research model for investigating plant defence
Wan Shen et al.
The Journal of nutritional biochemistry, 26(6), 616-625 (2015-03-25)
The objective of this study was to determine the extent to which a low level of trans-10, cis-12 (10,12) conjugated linoleic acid (CLA) decreases adiposity and increases browning in overweight mice, its dependence on inflammatory signaling and potential synergistic effects
Monika Siwetz et al.
The American journal of pathology, 185(5), 1334-1343 (2015-03-15)
The pathogenesis of preeclampsia (PE) includes the release of placental factors into the maternal circulation, inducing an inflammatory environment in the mother. One of the factors may be the proinflammatory chemokine fractalkine, which is expressed in the syncytiotrophoblast of human
Jiadi Sun et al.
Biosensors & bioelectronics, 70, 239-245 (2015-04-02)
A novel DNA sensor for the detection of the Escherichia coli O157:H7 (E. coli O157:H7) eaeA gene was constructed using surface enhanced fluorescence (SEF). The spacing distance dependence nature of Au@Ag nanorods surface enhanced fluorescence was investigated when the cy3-labled
Yutaka Sumino et al.
Physical review. E, Statistical, nonlinear, and soft matter physics, 85(4 Pt 2), 046307-046307 (2012-06-12)
The dynamics of a viscoelastic Maxwell fluid is studied in a partially filled cylinder rotating around a horizontal axis. At low rotational velocity, the fluid behaves in the same manner as a viscous fluid. A thin fluid film is pulled
Itsuro Kazama et al.
Immunopharmacology and immunotoxicology, 34(5), 874-878 (2012-03-14)
Lymphocytes predominantly express delayed rectifier K(+)-channels (Kv1.3) in their plasma membranes, and the channels play crucial roles in the lymphocyte activation and proliferation. Since nonsteroidal anti-inflammatory drugs (NSAIDs), the most commonly used analgesic and antipyretic drugs, exert immunomodulatory effects, they
Juliette Humeau et al.
Cell death & disease, 11(6), 433-433 (2020-06-10)
The integrated stress response is characterized by the phosphorylation of eukaryotic initiation factor-2α (eIF2α) on serine 51 by one out of four specific kinases (EIF2AK1 to 4). Here we provide three series of evidence suggesting that macroautophagy (to which we
Astam K Patra et al.
Journal of hazardous materials, 201-202, 170-177 (2011-12-16)
We report a highly efficient synthetic strategy for self-assembled mesoporous γ-Al(2)O(3) materials using sodium salicylate as template. The mesoporous γ-Al(2)O(3) samples synthesized following this strategy have high surface areas (231-497 m(2)g(-1)), consist of crystalline tiny spherical nanoparticles of dimensions ca.
Mohd Baasir Gaisawat et al.
Microorganisms, 8(1) (2020-01-08)
Clostridium (C.) difficile-infection (CDI), a nosocomial gastrointestinal disorder, is of growing concern due to its rapid rise in recent years. Antibiotic therapy of CDI is associated with disrupted metabolic function and altered gut microbiota. The use of probiotics as an
Guang-Di Chen et al.
Hearing research, 295, 100-113 (2012-12-04)
High doses of sodium salicylate (SS) have long been known to induce temporary hearing loss and tinnitus, effects attributed to cochlear dysfunction. However, our recent publications reviewed here show that SS can induce profound, permanent, and unexpected changes in the
Fangfang Liu et al.
Toxicology, 315, 17-23 (2013-11-28)
Life-threatening acute lung injury potentially occurs following high-level accidental exposures to phosgene gas. This situation was mirrored in rats exposed nose-only at 900-1000 mg phosgene/m(3)min. At this exposure level, previous studies on rats demonstrated sustained reflexively induced cardiopulmonary dysfunction and
Marco Pistolozzi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 69-78 (2014-01-30)
A series of novel tocainide analogues were characterized for their HSA and RSA binding, by using high-performance liquid affinity chromatography (HPLAC) and circular dichroism (CD). In this HPLAC study, HSA and RSA were covalently immobilized to the silica matrix of
Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
Niu H, et al.
BioMed Research International, 2018, 63-76 (2018)
E E Vincent et al.
Oncogene, 34(28), 3627-3639 (2014-09-23)
As a sensor of cellular energy status, the AMP-activated protein kinase (AMPK) is believed to act in opposition to the metabolic phenotypes favored by proliferating tumor cells. Consequently, compounds known to activate AMPK have been proposed as cancer therapeutics. However
Mark Zander et al.
Plant physiology, 165(4), 1671-1683 (2014-07-06)
Salicylic acid (SA), a hormone essential for defense against biotrophic pathogens, triggers increased susceptibility of plants against necrotrophic attackers by suppressing the jasmonic acid-ethylene (ET) defense response. Here, we show that this disease-promoting SA effect is abolished in plants lacking
Qian Zhang et al.
Acta biomaterialia, 8(3), 1316-1322 (2011-12-14)
Poly(amidoamine) (PAMAM) dendrons were prepared from hollow fiber membranes (HFM) consisting of bromomethylated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) in a stepwise manner. The prepared HFM were characterized by Fourier transform infrared spectroscopy, elemental analysis, and scanning electron microscopy. The drug loading efficiency
Pamela Romo-Rodríguez et al.
Chemosphere, 134, 563-570 (2015-01-13)
The Cr(VI) reducing capability of growing cells of the environmental A. tubingensis Ed8 strain is remarkably efficient compared to reference strains A. niger FGSC322 and A. tubingensis NRRL593. Extracellular glucose oxidase (GOX) activity levels were clearly higher in colonies developed
Mark Nixon et al.
Diabetes, 61(4), 790-796 (2012-02-24)
Recent trials show salicylates improve glycemic control in type 2 diabetes, but the mechanism is poorly understood. Expression of the glucocorticoid-generating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in adipose tissue is increased in vitro by proinflammatory cytokines and upregulated in
Takashi Kimitsuki et al.
Neuroscience letters, 504(1), 28-31 (2011-09-08)
Although salicylate is one of the most widely used nonsteroidal anti-inflammatory drugs, it causes moderate hearing loss and tinnitus at high-dose levels. In the present study, salicylate effects on the K currents in inner hair cells were examined. Salicylate reversibly
Cheng Liu et al.
Journal of cellular biochemistry, 113(1), 148-155 (2011-09-02)
Hypoxic-ischemia injury occurs after trauma causes consequential bone necrosis. Non-steroid anti-inflammatory drugs (NSAIDs) are frequently used in orthopedic clinics for pain relief. However, the underlying mechanism and outcome for usage of NSAIDs is poorly understood. To investigate the damage and
Yan-Yan Su et al.
PloS one, 7(10), e46969-e46969 (2012-10-17)
Sodium salicylate (NaSal), an aspirin metabolite, can cause tinnitus in animals and human subjects. To explore neural mechanisms underlying salicylate-induced tinnitus, we examined effects of NaSal on neural activities of the medial geniculate body (MGB), an auditory thalamic nucleus that
Xue Bai et al.
Nature communications, 5, 5702-5702 (2014-12-09)
White light-emitting diodes (WLEDs) are candidates to revolutionize the lighting industry towards energy efficient and environmental friendly lighting and displays. The current challenges in WLEDs encompass high luminous efficiency, chromatic stability, high colour-rending index and price competitiveness. Recently, the development
Sang-Yeon Lee et al.
Clinical and experimental otorhinolaryngology, 12(2), 169-175 (2018-10-27)
Sodium salicylate (SS) is well known for its ototoxic properties that induce functional and morphological changes in the cochlea and brain. Ginkgo biloba extract (GBE) has been widely used for treatment of various neurodegenerative diseases; however, its effects on salicylate-induced
Tara K Beattie et al.
Optometry and vision science : official publication of the American Academy of Optometry, 88(12), 1422-1432 (2011-09-20)
Sodium salicylate has shown potential as a component of contact lens care solutions designed to reduce Acanthamoebal attachment to contact lenses. This study determined the minimum effective concentration required to significantly reduce amoebal attachment. Different concentrations of sodium salicylate (10
Juen-Haur Hwang et al.
Journal of neuroinflammation, 8, 30-30 (2011-04-12)
Changes in the gene expressions for tumor necrosis factor-α (TNF-α) and/or interleukin-1β (IL-1β) during tinnitus have not been previously reported. We evaluated tinnitus and mRNA expression levels of TNF-α, IL-1β, and N-methyl D-aspartate receptor subunit 2B (NR2B) genes in cochlea
Kenjiro Bandow et al.
Bone, 74, 125-133 (2014-12-17)
Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been
Fernando G Osorio et al.
Genes & development, 26(20), 2311-2324 (2012-09-29)
Alterations in the architecture and dynamics of the nuclear lamina have a causal role in normal and accelerated aging through both cell-autonomous and systemic mechanisms. However, the precise nature of the molecular cues involved in this process remains incompletely defined.
Valérie Duval et al.
Journal of bacteriology, 195(15), 3341-3351 (2013-05-21)
The Escherichia coli regulator MarR represses the multiple-antibiotic resistance operon marRAB and responds to phenolic compounds, including sodium salicylate, which inhibit its activity. Crystals obtained in the presence of a high concentration of salicylate indicated two possible salicylate sites, SAL-A
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