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t5516
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Hormonal regulation of mannan-binding lectin synthesis in hepatocytes
Sorensen CM, et al.
Clinical and Experimental Immunology, 145(1), 173-182 (2006)
Hitoo Nishi et al.
Molecular and cellular biology, 31(4), 744-755 (2010-12-15)
MicroRNAs (miRNAs), small noncoding RNAs, are negative regulators of gene expression and play important roles in gene regulation in the heart. To examine the role of miRNAs in the expression of the two isoforms of the cardiac myosin heavy chain
Stephanie L Yahn et al.
Neurobiology of disease, 134, 104674-104674 (2019-11-16)
Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likely influenced by many aspects of the lesion environment including
Yoshiro Saito et al.
Journal of lipid research, 56(11), 2172-2182 (2015-09-29)
Selenocysteine (Sec) insertion sequence-binding protein 2 (SBP2) is essential for the biosynthesis of Sec-containing proteins, termed selenoproteins. Subjects with mutations in the SBP2 gene have decreased levels of several selenoproteins, resulting in a complex phenotype. Selenoproteins play a significant role
Agostina Nardone et al.
Cytotechnology, 63(1), 67-80 (2010-12-29)
A small subpopulation of stem/progenitor cells can give rise to the diversity of differentiated cells that comprise the bulk of the tumor. Are proliferating cells, within the bulk of tumor, few cells with uncommon features? The cell biological approach provides
Sarah E Conduit et al.
Human molecular genetics, 29(1), 31-48 (2019-10-19)
Polycystic kidney disease (PKD) results in the formation of renal cysts that can impair function leading to renal failure. DNA damage accumulates in renal epithelial cells in PKD, but the molecular mechanisms are unclear and are investigated here. Phosphoinositide 3-kinase
Sabine Sewing et al.
Molecular therapy. Nucleic acids, 14, 67-79 (2018-12-26)
Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has been shown to efficiently shift
Hormones Growth Factors & Oncogenes, 219-219 (1987)
Irene Antolino-Lobo et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(7), 1105-1112 (2010-04-15)
Metabolism plays an important role in the toxic effects caused by 3,4-methylenedioxymethamphetamine (MDMA). Most research has focused on the involvement of CYP2D6 enzyme in MDMA bioactivation, and less is known about the contribution of other cytochrome P450 (P450) and phase
Shinya Watanabe et al.
iScience, 24(6), 102688-102688 (2021-07-02)
Human induced pluripotent stem cells (hiPSCs) can generate a multiplicity of organoids, yet no compelling evidence currently exists as to whether or not these contain tissue-specific, holoclone-forming stem cells. Here, we show that a subpopulation of cells in a hiPSC-derived
Sara C Sebag et al.
Cell reports, 37(7), 110003-110003 (2021-11-18)
Brown adipose tissue (BAT) thermogenic activity is tightly regulated by cellular redox status, but the underlying molecular mechanisms are incompletely understood. Protein S-nitrosylation, the nitric-oxide-mediated cysteine thiol protein modification, plays important roles in cellular redox regulation. Here we show that
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Human colon tissue in organ culture: preservation of normal and neoplastic characteristics
Dame MK, et al.
In Vitro Cellular & Developmental Biology. Animal, 46(2), 114-122 (2010)
Katherine A Giles et al.
Clinical epigenetics, 13(1), 37-37 (2021-02-19)
BRG1 (encoded by SMARCA4) is a catalytic component of the SWI/SNF chromatin remodelling complex, with key roles in modulating DNA accessibility. Dysregulation of BRG1 is observed, but functionally uncharacterised, in a wide range of malignancies. We have probed the functions
Noemi García-Romero et al.
Cells, 9(6) (2020-06-11)
Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor in adults with a median overall survival of 15 months. Tumor recurrence and poor prognosis are related to cancer stem cells (CSCs), which drive resistance to therapies. A common
Medical Biochemistry, 769-769 (2001)
Patricia L Theard et al.
eLife, 9 (2020-09-09)
Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of multiple parallel RTKs further enhances EGFR-TKI effectiveness. We
Pradnya Gangatirkar et al.
Nature protocols, 2(1), 178-186 (2007-04-03)
This protocol describes an ex vivo three-dimensional coculture system optimized to study the skin regenerative ability of primary human keratinocytes grown at the air-liquid interface on collagen matrices embedded with human dermal fibroblasts. An option for enrichment of keratinocyte stem
Ricardo Cruz-Acuña et al.
Journal of cell science, 132(20) (2019-09-29)
Synthetic hydrogels with controlled physicochemical matrix properties serve as powerful in vitro tools to dissect cell-extracellular matrix (ECM) interactions that regulate epithelial morphogenesis in 3D microenvironments. In addition, these fully defined matrices overcome the lot-to-lot variability of naturally derived materials
Marianne K Vormann et al.
Journal of pharmaceutical sciences, 110(4), 1601-1614 (2021-02-06)
Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological architecture and flow. Here, we assessed a high throughput
Shozo Sonoda et al.
Nature protocols, 4(5), 662-673 (2009-04-18)
We provide our detailed, standardized in vitro protocol for the culture and differentiation of human retinal pigment epithelial (RPE) cells into a highly polarized and functional monolayer. Disruption of the polarized RPE function plays an important role in the pathogenesis
Benjamin W Darbro et al.
The Journal of investigative dermatology, 125(3), 499-509 (2005-08-25)
Cellular stasis, also known as telomere-independent senescence, prevents many epithelial cells from becoming immortalized by telomerase alone. As human keratinocytes age in culture, protein levels of the tumor suppressor p16INK4a continue to increase, resulting in growth arrest independent of telomere
Ana Feliu et al.
Glia, 68(6), 1255-1273 (2020-01-03)
The failure to remyelinate and regenerate is a critical impediment to recovery in multiple sclerosis (MS), resulting in severe dysfunction and disability. The chondroitin sulfate proteoglycans (CSPGs) that accumulate in MS lesions are thought to be linked to the failure
Belén Picatoste et al.
Molecular metabolism, 53, 101305-101305 (2021-07-25)
Recent studies indicate that brown adipose tissue, in addition to its role in thermogenesis, has a role in the regulation of whole-body metabolism. Here we characterize the metabolic effects of deleting Rab10, a protein key for insulin stimulation of glucose
Naofumi Yoshida et al.
iScience, 24(11), 103342-103342 (2021-11-23)
The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids (BCAA) and
Sheng Zhang et al.
Nature communications, 11(1), 2027-2027 (2020-04-26)
The mechanisms by which oligodendroglia modulate CNS angiogenesis remain elusive. Previous in vitro data suggest that oligodendroglia regulate CNS endothelial cell proliferation and blood vessel formation through hypoxia inducible factor alpha (HIFα)-activated Wnt (but not VEGF) signaling. Using in vivo
Yi Lu et al.
Science translational medicine, 12(554) (2020-07-31)
Oxidative stress is emerging as a crucial contributor to the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying the disturbed redox homeostasis in cystic cells remain elusive. Here, we identified the impaired activity of the
Mónica Durán et al.
Human molecular genetics, 30(15), 1413-1428 (2021-05-15)
Dent disease 1 (DD1) is a rare X-linked renal proximal tubulopathy characterized by low molecular weight proteinuria and variable degree of hypercalciuria, nephrocalcinosis and/or nephrolithiasis, progressing to chronic kidney disease. Although mutations in the electrogenic Cl-/H+ antiporter ClC-5, which impair
Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)
Jung-Feng Lin et al.
International journal of molecular sciences, 20(21) (2019-10-28)
Chronic renal failure involving hemodialysis results in blood loss during filtration. Iron deficiency and iron deficiency anemia can result. A compensatory increase in iron dosage has many side effects including discomfort. Elemental iron is a highly-pure iron source, which reduces
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