Marianne K Vormann et al.
Journal of pharmaceutical sciences, 110(4), 1601-1614 (2021-02-06)
Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological architecture and flow. Here, we assessed a high throughput