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Y0001092

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Alexandra Ursache et al.
Physiology & behavior, 138, 266-272 (2014-12-03)
Physiological responses to threat occur through both the autonomic nervous system (ANS) and the hypothalamic pituitary adrenal (HPA) axis. Activity in these systems can be measured through salivary alpha-amylase (sAA) and salivary cortisol, respectively. Theoretical work and empirical studies have...
Daniel Berry et al.
Developmental psychology, 50(2), 514-525 (2013-06-19)
A considerable body of literature suggests that children's child-care experiences may impact adrenocortical functioning in early childhood. Yet emerging findings also suggest that the magnitude and sometimes the direction of child-care effects on development may be markedly different for children...
Q Li et al.
Oncogene, 33(20), 2589-2600 (2013-06-12)
The major goal of breast cancer prevention is to reduce the incidence of ductal carcinoma in situ (DCIS), an early stage of breast cancer. However, the biology behind DCIS formation is not well understood. It is suspected that cancer stem...
Christine M Helfer et al.
Viruses, 6(8), 3228-3249 (2014-08-21)
The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral...
Ashley J Parks et al.
Molecular pharmacology, 86(5), 593-608 (2014-08-28)
The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape-based virtual...
Felice Strollo et al.
Aviation, space, and environmental medicine, 85(8), 793-797 (2014-09-10)
The Mars-105 project was aimed at simulating crew's activities, workload, and communication during a mission to Mars, evaluating the homeostatic adaptations to prolonged confinement and cohabitation. Fasting plasma glucose (FPG) and insulin, C-peptide, leptin, cortisol, and NGF and BDNF plasma...
Desseree Lysne et al.
Oncology reports, 32(6), 2541-2548 (2014-10-18)
Oral and oropharyngeal cancer together constitute the sixth most common cancer worldwide, with over 400,000 new cases diagnosed each year. Early detection is paramount, as the 5-year survival rate for these cancers decreases markedly once tumors have become regionally invasive....
F Hakami et al.
British journal of cancer, 111(4), 807-816 (2014-07-11)
HOX gene expression is altered in many cancers; previous microarray revealed changes in HOX gene expression in head and neck squamous cell carcinoma (HNSCC), particularly HOXD10. HOXD10 expression was assessed by qPCR and immunoblotting in vitro and by immunohistochemistry (IHC)...
Jun Ma et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(11), 1826-1836 (2014-09-04)
Blood-tumor barrier (BTB) constitutes an efficient organization of tight junctions that impairs the delivery of therapeutic drugs. However, the methods and molecular mechanisms underlying the BTB opening remain elusive. MicroRNAs (miRNAs) have recently emerged as key regulators of various biologic...
Fei-Hsiu Hsiao et al.
Psychoneuroendocrinology, 53, 60-68 (2015-01-16)
This study aimed to identify predictors of changes in diurnal cortisol patterns during the 8-month follow up period for young breast cancer survivors. Among the potential predictors were tumor size, lymph node metastasis, changes in sleep problems, habitual time of...
Jasper H B de Groot et al.
PloS one, 10(2), e0118211-e0118211 (2015-02-28)
Humans can register another person's fear not only with their eyes and ears, but also with their nose. Previous research has demonstrated that exposure to body odors from fearful individuals elicited implicit fear in others. The odor of fearful individuals...
Jun-Jie Guan et al.
Tissue engineering. Part A, 20(13-14), 1794-1806 (2014-01-07)
Stem cells in human urine have gained attention in recent years; however, urine-derived stem cells (USCs) are far from being well elucidated. In this study, we compared the biological characteristics of USCs with adipose-derived stem cells (ASCs) and investigated whether...
Christina Maria Anna Pia Schuh et al.
Cytotherapy, 16(12), 1666-1678 (2014-09-02)
Adipose-derived progenitor/stem cells (ASCs) are discussed as a promising candidate for various tissue engineering approaches. However, its applicability for the clinic is still difficult due to intra- and inter-donor heterogeneity and limited life span in vitro, influencing differentiation capacity as...
Sarah J Lehnert et al.
Genetica, 142(4), 281-293 (2014-06-24)
Outbreeding, mating between genetically divergent individuals, may result in negative fitness consequences for offspring via outbreeding depression. Outbreeding effects are of notable concern in salmonid research as outbreeding can have major implications for salmon aquaculture and conservation management. We therefore...
Tong Guo et al.
Alternatives to laboratory animals : ATLA, 42(4), 235-243 (2014-10-08)
Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research community and, ultimately, patients. In this study, we tested the lung slice culture...
Pascal Dao et al.
Cancer letters, 348(1-2), 88-99 (2014-03-25)
FAK and FGFR2 signaling pathways play important roles in cancer development, progression and tumor angiogenesis. PHM16 is a novel ATP competitive inhibitor of FAK and FGFR2. To evaluate the therapeutic efficacy of this agent, we examined its anti-angiogenic effect in...
Weiwei Dai et al.
Bone, 74, 48-57 (2015-01-15)
Beta-ecdysone (βEcd) is a phytoecdysteroid found in the dry roots and seeds of the asteraceae and achyranthes plants, and is reported to increase osteogenesis in vitro. Since glucocorticoid (GC) excess is associated with a decrease in bone formation, the purpose...
Jackie Swartz et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 26(2), 153-160 (2015-01-27)
Infants from anthroposophic families have low cortisol levels and low risk of IgE-sensitization during first 2 years of life. Our aim was to study the impact of an anthroposophic lifestyle and cortisol levels at 6 months on allergy sensitization up to age...
Olga Vaksman et al.
Carcinogenesis, 35(9), 2113-2120 (2014-06-14)
The objective of this study was to analyze the expression, biological role and clinical relevance of exosomal microRNAs (miRNAs) from ovarian carcinoma (OC) effusion supernatants. Exosomal miRNA expression profiling was performed using miRNA Taqman arrays. Selected miRNAs were validated using...
Liselotte van Bloemendaal et al.
Diabetes, 63(12), 4186-4196 (2014-07-30)
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in...
Mirko Peitzsch et al.
The Journal of steroid biochemistry and molecular biology, 145, 75-84 (2014-10-15)
Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/MS). Adrenal venous (AV) measurements of aldosterone and cortisol are a standard practice in the...
S Ott et al.
Research in veterinary science, 97(1), 124-128 (2014-06-25)
Most commonly, salivary cortisol is used in pig stress assessment, alternative salivary biomarkers are scarcely studied. Here, salivary cortisol and two alternative salivary biomarkers, haptoglobin and chromogranin A were measured in a pig stress study. Treatment pigs (n = 24) were exposed...
Carol Best et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 190-198 (2014-07-19)
The antidepressant venlafaxine is detected at parts per billion levels in tertiary-treated municipal wastewater effluent. However, the impact of this serotonin-norepinephrine reuptake inhibitor (SNRI) on non-target aquatic animals is poorly understood. We tested the hypothesis that environmentally relevant levels of...
S Kumar et al.
Oncogene, 33(30), 3970-3979 (2013-10-01)
Endoglin is a transforming growth factor β (TGF-β) coreceptor that serves as a prognostic, diagnostic and therapeutic vascular target in human cancer. A number of endoglin ectodomain-targeting antibodies (Abs) can effectively suppress both normal and tumor-associated angiogenesis, but their molecular...
Wee Shuan Yo et al.
Clinical endocrinology, 81(1), 19-24 (2013-11-28)
Previous studies have demonstrated that a morning serum cortisol of <100 nmol/l makes further dynamic testing such as the Synacthen stimulation test (SST) unnecessary to confirm adrenal insufficiency. The morning cortisol level that reliably predicts adrenal sufficiency (AS) is less...
L E Moore et al.
Journal of perinatology : official journal of the California Perinatal Association, 21(7), 456-458 (2002-03-16)
To review the literature on alternatives to betamethasone and dexamethasone for enhancement of fetal lung maturity. A medline search was conducted from 1966 to the present. Trials dealing with enhancement of fetal lung maturity using modalities other than betamethasone or...
Andrea L Glenn et al.
Psychoneuroendocrinology, 54, 14-23 (2015-02-11)
Recent investigations of the psychobiology of stress in antisocial youth have benefited from a multi-system measurement model. The inclusion of salivary alpha-amylase (sAA), a surrogate marker of autonomic/sympathetic nervous system (ANS) activity, in addition to salivary cortisol, a biomarker of...
Suman Kanji et al.
Stem cell research, 12(1), 275-288 (2013-12-11)
Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy is under consideration for treating peripheral and cardiac ischemia. However, the therapeutic efficacy of nanofiber-expanded human umbilical cord blood-derived (NEHUCB) CD34+ cell therapy for wound healing and its mechanisms are yet to...
Andrea Oßwald et al.
European journal of endocrinology, 171(2), 209-215 (2014-07-01)
Bilateral adrenalectomy (BADX) is an important treatment option for patients with Cushing's syndrome (CS). Our aim is to analyze the long-term outcomes, surgical, biochemical, and clinical as well as morbidity and mortality, of patients who underwent BADX. A total of...
E Turrini et al.
Journal of ethnopharmacology, 162, 261-269 (2015-01-07)
The decoction of the roots of Hemidesmus indicus is widely used in the Indian traditional medicine for many purposes and poly-herbal preparations containing Hemidesmus are often used by traditional medical practitioners for the treatment of cancer. In the context of...
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