TPGS-750-M: a second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature.

The Journal of organic chemistry (2011-05-10)
Bruce H Lipshutz, Subir Ghorai, Alexander R Abela, Ralph Moser, Takashi Nishikata, Christophe Duplais, Arkady Krasovskiy, Ricky D Gaston, Robert C Gadwood

An environmentally benign surfactant (TPGS-750-M), a diester composed of racemic α-tocopherol, MPEG-750, and succinic acid, has been designed and readily prepared as an effective nanomicelle-forming species for general use in metal-catalyzed cross-coupling reactions in water. Several "name" reactions, including Heck, Suzuki-Miyaura, Sonogashira, and Negishi-like couplings, have been studied using this technology, as have aminations, C-H activations, and olefin metathesis reactions. Physical data in the form of DLS and cryo-TEM measurements suggest that particle size and shape are key elements in achieving high levels of conversion and, hence, good isolated yields of products. This new amphiphile will soon be commercially available.

Referencia del producto
Descripción del producto

DL-α-Tocopherol methoxypolyethylene glycol succinate solution, 2 wt. % in H2O
DL-α-Tocopherol methoxypolyethylene glycol succinate solution, 5 wt. % in H2O
Buchwald-Hartwig Amination in a Box
Olefin Metathesis in a Box
Negishi Coupling in a Box

Redes sociales

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Investigación. Desarrollo. Producción.

Somos un proveedor líder para la industria de Ciencias de la Vida con soluciones y servicios para investigación, desarrollo y producción biotecnológicos, y para desarrollo y producción de tratamientos farmacéuticos

© 2021 Merck KGaA, Darmstadt, Alemania y/o sus filiales. Todos los derechos reservados.

Queda estrictamente prohibida la reproducción sin permiso de cualquiera de los materiales de la página web.