Merck

Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions.

Cell cycle (Georgetown, Tex.) (2010-12-15)
Hao-Wei Wang, Johanna A Joyce
RESUMEN

Although macrophages were originally recognized as major immune effector cells, it is now appreciated that they also play many important roles in the maintenance of tissue homeostasis, and are involved in a variety of pathological conditions including cancer. Several studies have demonstrated the contributions of tumor-associated macrophages (TAMs) to tumor initiation, progression, and metastasis. However, the detailed mechanisms underlying how TAMs differ molecularly from their normal counterparts and how the conversion to TAMs occurs have only just begun to be understood. TAMs have been proposed to exhibit phenotypes of 'alternatively activated' macrophages, though there has been limited evidence directly linking the phenotypes of TAMs to the alternative activation of macrophages. This review will focus on IL-4, the prototypic cytokine that induces the alternative activation of macrophages, and review current knowledge regarding the contributions of IL-4 to the phenotypes of TAMs and its effects on tumorigenesis.

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Sigma-Aldrich
Monoclonal Anti-Interleukin-4 antibody produced in mouse, clone 3007, purified immunoglobulin, lyophilized powder
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Monoclonal Anti-Interleukin-4 antibody produced in mouse, clone 3010, purified immunoglobulin, lyophilized powder
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Anti-Interleukin-4 Soluble Receptor antibody produced in goat, IgG fraction of antiserum, lyophilized powder
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Monoclonal Anti-Interleukin-4−R-Phycoerythrin antibody produced in mouse, clone 3007.11, purified immunoglobulin, buffered aqueous solution
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Anti-Interleukin-4 antibody produced in goat, affinity isolated antibody, lyophilized powder
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Monoclonal Anti-Interleukin-4−Carboxyfluorescein antibody produced in mouse, clone 3007.11, purified immunoglobulin, buffered aqueous solution
Sigma-Aldrich
Anti-Interleukin-4 antibody produced in goat, affinity isolated antibody, lyophilized powder