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Polyurethane Microstructures--a Good or Bad in vitro Partner for the Isoflavone Genistein?

Natural product communications (2015-07-23)
Corina Danciu, Florin Borcan, Codruta Soica, Istvan Zupko, Erzsébet Csányi, Rita Ambrus, Delia Muntean, Camelia Sass, Diana Antal, Claudia Toma, Cristina Dehelean
ABSTRACT

In recent years polyurethane microstructures (PM) have gained increasing attention in the pharmaceutical field due to the importance of their practical application. Since finding that such a formulation with genistein could improve its applications, we have conducted a preliminary study regarding the in vitro antiproliferative (MCF7, MDA-MB-231 and T47D) and antimicrobial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis (D), Bacillus subtilis, B. cereus, and Candida albicans) activity in order to test whether polyurethane micro structuresre present a good option for further modulation of genistein's bioavailability. It was concluded that the polyurethane micro structures are a bad in vitro partner for the isoflavone genistein.

MATERIALS
Product Number
Brand
Product Description

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2-Propanol, anhydrous, 99.5%
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L-Lysine monohydrochloride, reagent grade, ≥98% (HPLC)
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L-Lysine monohydrochloride, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
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2-Propanol, BioReagent, for molecular biology, ≥99.5%
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2-Propanol, electronic grade, 99.999% trace metals basis
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Ethylene glycol solution, NMR reference standard, 80% in DMSO-d6 (99.9 atom % D), NMR tube size 5 mm × 8 in.
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