The product has the phosphate containing material including free inorganic phosphate from breakdown.
A1752
Adenosine 5′-monophosphate sodium salt
≥99%, from yeast, powder
Synonym(s):
5′-Adenylic acid, A-5′-P, AMP
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€341.00
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About This Item
Empirical Formula (Hill Notation):
C10H14N5O7P · xNa+ · yH2O
CAS Number:
Molecular Weight:
347.22 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
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Product Name
Adenosine 5′-monophosphate sodium salt, from yeast, ≥99%
biological source
yeast
Quality Level
Assay
≥99%
form
powder
solubility
H2O: soluble
storage temp.
−20°C
SMILES string
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@]((COP(O)(O)=O)([H])O3.C.
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1 of 4
This Item | A2252 | A9272 | A0386 |
|---|---|---|---|
| biological source yeast | biological source yeast | biological source yeast | biological source yeast |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| assay ≥99% | assay ≥97% | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: soluble | solubility 1 M NH4OH: soluble 50 mg/mL, clear, colorless, H2O: soluble (with addition of mild alkali) | solubility 1 N NH4OH: 50 mg/mL, clear, colorless | solubility water: 100 mg/mL, clear to very slightly hazy, colorless to very faintly yellow |
Application
Adenosine 5′-monophosphate sodium salt has been used:
- as a component of reactivation medium to reactivate mouse sperm extracted from caudae epididymides for sperm motility studies [1]
- as a substrate in signal amplification by reversible exchange (SABRE) method to develop biocompatible SABRE hyperpolarization[2]
- as a substrate in wheat and Aspergillus niger phytase, assay[3]
- in luciferase assay to monitor intracellular α-synuclein oligomerization in S1S2 cells[4]
- to study its effects on induction of therapeutic hypothermia and neuronal damage in a rat model of cardiac arrest (CA) and resuscitation[5]
Biochem/physiol Actions
Adenosine 5′-monophosphate (5′-AMP) is used to enhance flavor in meat and poultry soups. It is also used as a food additive for specific nutritional purposes.[6] 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). [7] Along with inosine monophosphate (IMP), AMP mediates the dissociation of skeletal muscle actomyosin to actin and myosin. Therefore, these two factors may be involved in causing the resolution of rigor mortis in muscles.[8]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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D Grahame Hardie
Genes & development, 25(18), 1895-1908 (2011-09-23)
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase
Yugo Tsuchiya et al.
Bioscience reports, 32(2), 197-213 (2011-08-20)
In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase) activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α-Thr172) and decreased phosphorylation of ACC (acetyl-CoA carboxylase). Inactivation of AMPK by adrenaline was through both α1- and
Jürgen Knapp et al.
Resuscitation, 85(9), 1291-1297 (2014-07-01)
Animal studies and pathophysiological considerations suggest that therapeutic hypothermia after cardiopulmonary resuscitation is the more effective the earlier it is induced. Therefore this study is sought to examine whether pharmacological facilitated hypothermia by administration of 5'-adenosine monophosphate (AMP) is neuroprotective
Akihiro Okitani et al.
Bioscience, biotechnology, and biochemistry, 72(8), 2005-2011 (2008-08-08)
We investigated to determine why heating of squid muscle at 60 degrees C induced the liberation of actin from myofibrils. When a mixture of a myofibrillar fraction and a low-molecular sarcoplasmic fraction prepared from squid muscle was heated at 60
Daoying Wang et al.
Journal of the science of food and agriculture, 96(5), 1467-1473 (2015-05-09)
Adenosine 5'-monophosphate (AMP) is often used in meat and poultry soups as a flavor enhancer (flavor modifier), or as food additives for specific nutritional purposes. Our previous research as well as evidence from others showed that actomyosin could be dissociated
Protocols
To measure 5′-nucleotidase activity, this procedure uses adenosine 5’-monophosphate and a color reagent to create a standard curve for determining the micromoles of phosphorus liberated.
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
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