The purpose of the charcoal purification step is to remove fatty acids from the albumin solution, and it has been verified that no traces of charcoal are present in the final product. As for ensuring that components of the buffer used for lyophilization are not present in the final product, it is currently considered salt-free, but there is potential to characterize it by ICP-MS.
A1887
Albumin from human serum
lyophilized powder, essentially fatty acid free
Synonym(s):
HSA
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About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42010201
NACRES:
NA.25
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biological source
human
Quality Level
Assay
≥96% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer calculated mol wt 66478 Da
technique(s)
ELISA: suitable
tissue culture: suitable
western blot: suitable
impurities
HIV I and HIVII, HCV and HBsAg, tested negative
≤0.007% Fatty Acids
solubility
H2O: soluble 50 mg/mL, clear to slightly hazy
UniProt accession no.
storage temp.
2-8°C
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Gene Information
human ... ALB(213)
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This Item | A8301 | 126654 | 12667-M |
|---|---|---|---|
| assay ≥96% (agarose gel electrophoresis) | assay 90-100% protein basis (biuret) | assay ≥95% (SDS-PAGE) | assay ≥95% (agarose gel electrophoresis) |
| technique(s) ELISA: suitable, western blot: suitable, tissue culture: suitable | technique(s) cell culture | mammalian: suitable | technique(s) protein quantification: suitable | technique(s) cell culture | mammalian: suitable |
| biological source human | biological source human | biological source - | biological source human |
| Quality Level 300 | Quality Level 200 | Quality Level - | Quality Level - |
| form lyophilized powder | form lyophilized powder | form lyophilized solid (Salt-free) | form liquid |
| Gene Information human ... ALB(213) | Gene Information human ... ALB(213) | Gene Information - | Gene Information - |
General description
Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.[1]
Application
Biochem/physiol Actions
Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.
Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.
Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport.[5] The albumin levels in the serum indicate the disease progression in advanced liver disease.[1] Low body weight and decreased serum albumin is associated with colorectal cancer.[6]
Preparation Note
Prepared from albumin (A1653)
Other Notes
View more information on human serum albumin.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
comparable product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Jasper V Been et al.
Respiratory research, 10, 116-116 (2009-11-26)
Preterm infants are highly susceptible to lung injury. While both chorioamnionitis and antenatal steroids induce lung maturation, chorioamnionitis is also associated with adverse lung development. We investigated the ability of bronchoalveolar lavage fluid (BALF) from ventilated preterm infants to restore
J Barré et al.
Clinical chemistry, 31(1), 60-64 (1985-01-01)
Equilibrium dialysis, ultrafiltration, and ultracentrifugation were compared to determine their reliability and applicability in the study of binding of an anticonvulsant drug, valproic acid, by plasma proteins. We studied drug binding with pooled serum and with solutions of human serum
Effect of acetonitrile on the hydration of human serum albumin films: a calorimetric and spectroscopic study
Sirotkin VA and Korolev DV
Thermochimica Acta, 432(2), 246-253 (2005)
Sorption of water vapor and acetonitrile by human serum albumin
Sirotkin VA, et al.
Russian Journal of Physical Chemistry A, 76(12), 2051-2057 (2002)
Di Wu et al.
Scientific reports, 9(1), 1615-1615 (2019-02-09)
The main aim of this work was to gain insight into the binding properties between a food colorant, citrus red 2 (CR), and human serum albumin (HSA), which is the predominant protein in blood plasma. Here, computer simulations and multiple
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