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Merck

C2538

Sigma-Aldrich

Carboplatin

DNA cross-linking agent, powder

Synonym(s):

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

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About This Item

Linear Formula:
[C4H6(CO2)2]Pt(NH3)2
CAS Number:
41575-94-4
Molecular Weight:
371.25
EC Number:
255-446-0
MDL number:
MFCD00070464
UNSPSC Code:
12352200
PubChem Substance ID:
24278303
NACRES:
NA.77

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Product Name

Carboplatin,

form

powder

Quality Level

100

antibiotic activity spectrum

neoplastics

originator

Bristol-Myers Squibb

SMILES string

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-L

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This Item
1096407216100-MBP711
Carboplatin

Sigma-Aldrich

C2538

Carboplatin

Carboplatin United States Pharmacopeia (USP) Reference Standard

USP

1096407

Carboplatin

Carboplatin An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.

Millipore

216100-M

Carboplatin

Carboplatin British Pharmacopoeia (BP) Reference Standard

BP711

Carboplatin

form

powder

form

-

form

solid

form

solid

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

originator

Bristol-Myers Squibb

originator

-

originator

-

originator

-

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

General description

Carboplatin is used to treat testicular, ovarian and breast cancer.[1]

Application

Carboplatin has been used:
  • in chemotherapy-induced thrombocytopenia mouse model and treatment[2]
  • to induce cell death in a large subset of colorectal cancer cells[3]
  • in the evaluation of cell proliferation and chemosensitivity[4]
  • as a positive control for suppressed cell growth[5]

Biochem/physiol Actions

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ0527
MKCW1333
MKCT7823
MKCR3593
MKCR8746

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Osteoblasts support megakaryopoiesis through production of interleukin 9
Xiao M, et al.
Blood, blood-b2016 (2017)
Furqan Shaikh et al.
Pediatric blood & cancer, 60(4), 587-592 (2012-09-15)
While cisplatin is considered superior to carboplatin for the treatment of malignant germ cell tumors (MGCTs) in adults, pediatric oncology collaborative groups still remain concerned about the late effects of cisplatin in children. We performed a literature search to identify
Joel Shapiro et al.
Annals of surgery, 258(5), 678-688 (2013-10-08)
To gain insight into the exact location of residual esophageal cancer in the esophageal wall and regional lymph nodes after neoadjuvant chemoradiotherapy (nCRT) and to determine the pattern of regression. Data from the recently published chemoradiotherapy for oesophageal cancer followed
Selective toxicity of rose bengal to ovarian cancer cells in vitro
Koevary SB
International Journal of Physiology, Pathophysiology and Pharmacology, 4(2), 99-99 (2012)
Michael D Nyquist et al.
Cell reports, 31(8), 107669-107669 (2020-05-28)
Prostate cancers (PCs) with loss of the potent tumor suppressors TP53 and RB1 exhibit poor outcomes. TP53 and RB1 also influence cell plasticity and are frequently lost in PCs with neuroendocrine (NE) differentiation. Therapeutic strategies that address these aggressive variant
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Related Content

Product Information Sheet - C2538

Product Information Sheet

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