S4317

SB 431542 hydrate

≥98% (HPLC), powder, inhibits activation of SMAD proteins

• Synonym(s): 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
• Empirical Formula (Hill Notation): C₂₂H₁₆N₄O₃ · xH₂O
• CAS Number: 301836-41-9
• Molecular Weight: 384.39 (anhydrous basis)
• MDL number: MFCD11045982
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724609
• NACRES: NA.77

Properties

• Product Name: SB 431542 hydrate, ≥98% (HPLC), powder
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: soluble 10 mg/mL; H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: −20°C
• SMILES string: O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
• InChI: 1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
• InChI key: WQUIJVKNPYBZOF-UHFFFAOYSA-N

Description

Application

SB-431542 was used to study the correlation of platelet-derived growth factor receptor B expression and TGF-β pathway activation in colorectal tumor cells.[1] It was used to study the role of TGF-β signaling in modulation of extracellular matrix[2] and myoblast differentiation.[3]

Biochem/physiol Actions

Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.

SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility.[4][5][6] It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.[5]

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves