SML4269

740 Y-P trifluoroacetate

≥95% (HPLC)

• Synonym(s): 740 YP trifluoroacetate, 740-YP trifluoroacetate, 740Y-P trifluoroacetate, 740YP trifluoroacetate, 740YPDGFR trifluoroacetate, PDGFR 740Y-P trifluoroacetate, RQIKIWFQNRRMKWKK-SDGGY(P)MDMS trifluoroacetate, RQIKIWFQNRRMKWKK-SDGGpYMDMS trifluoroacetate, Arg-Gln-Ile-Lys-Ile-Try-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-Tyr(P)-Met-Asp-Met-Ser trifluoroacetate
• Empirical Formula (Hill Notation): C₁₄₁H₂₂₂N₄₃O₃₉PS₃ · xC₂HF₃O₂
• CAS Number: 1236188-16-1
• Molecular Weight: 3270.70 (free base basis)
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C

Description

General description

Cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator.
740 Y-P is a cell-permeable phosphatidylinositol 3-kinase (PI 3-kinase, PI3K) activator composed of the Drosophila antennapedia-derived membrane-permeant 16-mer sequence RQIKIWFQNRRMKWKK followed by a phosphotyrosine-containing, PDGFR-derived sequence SDGGY(P)MDMS that targets SH2 domains of PI3K p85 regulatory subunit. When applied to serum-starved C2 cells at 50 µg/mL, 740 Y-P is more effective than 10% FCS, 5 ng/mL bFGF or 10 ng/mL EGF in stimulating cell proliferation (% of cells in S-phase post 48h stimulation = 48.3, 42.5, 35.7 and 32.8, respectively). 740 Y-P-induced mitogenic response is blocked by wortmannin or rapamycin, but not MEK inhibitor PD98058.

Disclaimer

Hygroscopic Store with desiccant