Merck

1.08486

SAFC

Urea

crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP

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Synonym(s):
Carbamide, Carbonyl diamide, Diaminomethanone, Carbonyldiamine, Carbamide, Carbonyldiamide
Linear Formula:
NH2CONH2
CAS Number:
Molecular Weight:
60.06
Beilstein:
635724
MDL number:
EC Index Number:
200-315-5

Agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

98.0-102.0% (HPLC)

form

crystalline
solid

technique(s)

titration: suitable

pH

9 (20 °C, 100 g/L in H2O)

mp

132-135 °C (lit.)

solubility

1000 g/L

density

1.335 g/mL at 25 °C (lit.)

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

SMILES string

NC(N)=O

InChI

1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

InChI key

XSQUKJJJFZCRTK-UHFFFAOYSA-N

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1 of 4

This Item
U0600000BP3501.08487
Urea crystalline, EMPROVE&#174; ESSENTIAL, Ph. Eur., BP, ChP, JP, USP

SAFC

1.08486

Urea

Urea European Pharmacopoeia (EP) Reference Standard

U0600000

Urea

Urea British Pharmacopoeia (BP) Reference Standard

BP350

Urea

Urea GR for analysis ACS,Reag. Ph Eur

Supelco

1.08487

Urea

technique(s)

titration: suitable

technique(s)

-

technique(s)

-

technique(s)

titration: suitable

agency

BP

agency

-

agency

-

agency

reag. Ph. Eur.

vapor pressure

<0.1 hPa ( 20 °C)

vapor pressure

-

vapor pressure

-

vapor pressure

<0.1 hPa ( 20 °C)

assay

98.0-102.0% (HPLC)

assay

-

assay

-

assay

-

form

crystalline

form

-

form

-

form

solid

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Urea is typically used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. It is useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. Urea may be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.
Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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