Merck

1.37037

SAFC

Guanidinium chloride

EMPROVE® EXPERT, NF

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Synonym(s):
Guanidine hydrochloride, Guanidinum hydrochloride, Carbamimidoylazanium chloride, Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride
Linear Formula:
NH2C(=NH)NH2 · HCl
CAS Number:
Molecular Weight:
95.53
Beilstein:
3591990
MDL number:
EC Index Number:
200-002-3

Agency

NF

Quality Level

product line

EMPROVE® EXPERT

potency

655.3-907.1 mg/kg LD50, oral (Rat)
>2000 mg/kg LD50, skin (Rabbit)

pH

4.5-5.5 (20 °C, 100 g/L in H2O)

mp

180-185 °C (lit.)
188 °C

solubility

2150 g/L

density

1.3 g/cm3 (lit.)

bulk density

550‑620 kg/m3

storage temp.

2-30°C

SMILES string

Cl[H].NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

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1 of 4

This Item
50933369080G4505
vibrant-m

1.37037

Guanidinium chloride

-
vibrant-m

50933

Guanidine hydrochloride

Premium Grade
vibrant-m

G4505

Guanidine hydrochloride

-
Quality Level

500

Quality Level

200

Quality Level

100

Quality Level

400

pH

4.5-5.5 (20 °C, 100 g/L in H2O)

pH

4.5-6.0 (25 °C, 6 M in H2O)

pH

-

pH

(25 °C, 4.6 - 6 at 573 g/L)

mp

180-185 °C (lit.), 188 °C

mp

180-185 °C (lit.)

mp

-

mp

180-185 °C (lit.)

density

1.3 g/cm3 (lit.)

density

1.3 g/cm3 (lit.)

density

-

density

1.3 g/cm3 (lit.)

agency

NF

agency

-

agency

-

agency

-

General description

Finding the right chemical that matches your pharma and biopharma manufacturing needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for pharma and biopharma manufacturing withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Other Notes

Due to its low microbial and endotoxin limits, Guanidinium chloride Emprove® Expert is suitable for biopharma manufacturing needs.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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