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178220

Sigma-Aldrich

Antipain, Hydrochloride

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.

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Synonym(s):
Antipain, Hydrochloride
Empirical Formula (Hill Notation):
C27H44N10O6 · xHCl
CAS Number:
Molecular Weight:
604.70 (free base basis)
MDL number:

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white to slightly yellowish

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1

InChI key

GXQPAKIVOCLCHD-BXLPLHKWSA-N

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Antipain, Hydrochloride Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.

178220

Antipain, Hydrochloride

Antipain, Dihydrochloride Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.

178223

Antipain, Dihydrochloride

Antipain dihydrochloride crystalline, suitable for cell culture, pkg of 10 mg

11004646001

Antipain dihydrochloride

Sigma-Aldrich

178281

p-APMSF, Hydrochloride

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Roche

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

-

storage condition

OK to freeze, desiccated

solubility

water: 10 mg/mL

solubility

water: 1 mg/mL, DMSO: 5 mg/mL

solubility

DMSO: 20 mg/mL, methanol: 20 mg/mL, water: 20 mg/mL, benzene: insoluble, chloroform: insoluble, ethanol: sparingly soluble, hexane: insoluble

solubility

water: 25 mg/mL

General description

Effective concentration: 1-100 µM.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC50 ~500 ng/ml). Effective at concentrations of 1-100 µM.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Trypsin-like serine proteases
Product does not compete with ATP.
Reversible: no
Target IC50: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Other Notes

Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Umezawa, H. 1976. Methods Enzymol.55, 678.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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