Merck
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440025

Sigma-Aldrich

Luteolin - CAS 491-70-3 - Calbiochem

An antioxidant flavonoid and a free radical scavenger.

Synonym(s):
Luteolin - CAS 491-70-3 - Calbiochem, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone
Empirical Formula (Hill Notation):
C15H10O6
CAS Number:
Molecular Weight:
286.24
MDL number:

Quality Level

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

aqueous base: 1.4 mg/mL
DMSO: 7 mg/mL
ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

InChI key

IQPNAANSBPBGFQ-UHFFFAOYSA-N

General description

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

Packaging

5 mg in Glass bottle
Packaged under inert gas

Biochem/physiol Actions

Cell permeable: no
Primary Target
rat liver cytosolic glutathione S-transferase activity
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Other Notes

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Quality

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