Merck
  • SCT246
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SCT246

Sigma-Aldrich

BioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe

All Photos(1)
Synonym(s):
G quadruplex probe, G4 ligand, G4 probe, G4 tetrad probe, Live Cell Imaging Probe

packaging

vial of 1 mg

Quality Level

100

manufacturer/tradename

Millipore

growth mode

N/A

technique(s)

DNA sequencing: suitable
RNA extraction: suitable
nucleic acid detection: suitable

detection method

fluorometric

shipped in

dry ice

storage temp.

−20°C

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BioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe

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manufacturer/tradename

Millipore

manufacturer/tradename

Millipore

manufacturer/tradename

-

manufacturer/tradename

Millipore

growth mode

N/A

growth mode

N/A

growth mode

-

growth mode

-

technique(s)

DNA sequencing: suitable, RNA extraction: suitable, nucleic acid detection: suitable

technique(s)

DNA sequencing: suitable, RNA extraction: suitable, nucleic acid detection: suitable

technique(s)

cell based assay: suitable

technique(s)

cell based assay: suitable

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

Application

G-quadruplexes are four-stranded structures comprising stacked G tetrads (G4) formed within certain guanine-rich nucleic acid sequences. G-quadruplexes are enriched in open chromatin regions but are also present in the nucleolus and cytoplasm. The formation of G4 structures is dynamic and cell-type specific, suggestive of interaction with transcription factors and other proteins. For this reason G-quadruplexes have garnered intense interest for their potential role in transcriptional regulation.

The BioTracker™ BioCyTASQ G-quadruplex G4 cell probe is optimized for detection of G-quadruplexes. BioCyTASQ utilizes the template-assembled synthetic G-quartets (TASQ) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.

References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914
Purity: > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.

Features and Benefits

BioCyTASQ detects ribosomal RNA associated with perinuclear rough ER regions. BioCyTASQ is suitable for G4 capture pull-down assays as well as cellular imaging.2 BioCyTASQ G4 probe is not recommended for live-cell imaging applications. The biotinylated BioTracker BioCyTASQ G-quadruplex G4 cell probe makes is a powerful tool for biochemical and cellular analysis of G4 by fluorescent detection when used with a fluorescent streptavidin.

Physical form

Lyophilized. White solid.

Storage and Stability

Store BioTracker BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light

Other Notes

Fluorescent detection of nucleic acid G4 quadruplexes in cells and tissues

Legal Information

BioTracker is a trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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