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186562

Sigma-Aldrich

Tetrahydrofuran

anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

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Synonym(s):
THF, Butylene oxide, Oxolane, Tetramethylene oxide
Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
Beilstein:
102391
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

anhydrous

Quality Level

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

Assay

≥99.9%

form

liquid

autoignition temp.

610 °F

contains

250 ppm BHT as inhibitor

expl. lim.

1.8-11.8 %

impurities

≤0.005% peroxides (as H2O2)
<0.002% water (All units except 100 mL)
<0.005% water (100 mL pkg)

refractive index

n20/D 1.407 (lit.)

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

H2O: soluble

density

0.889 g/mL at 25 °C (lit.)

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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1 of 4

This Item
360589178810-M87369
Tetrahydrofuran anhydrous, contains 250&#160;ppm BHT as inhibitor, &#8805;99.9%

Sigma-Aldrich

186562

Tetrahydrofuran

Tetrahydrofuran contains 250&#160;ppm BHT as inhibitor, ACS reagent, &#8805;99.0%

Sigma-Aldrich

360589

Tetrahydrofuran

Tetrahydrofuran reagent grade, &#8805;99.0%, contains 250&#160;ppm BHT as inhibitor

Sigma-Aldrich

178810-M

Tetrahydrofuran

Tetrahydrofuran Selectophore&#8482;, &#8805;99.5%

Supelco

87369

Tetrahydrofuran

vapor density

2.5 (vs air)

vapor density

2.5 (vs air)

vapor density

2.5 (vs air)

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

assay

≥99.9%

assay

≥99.0%

assay

≥99.0%

assay

≥99.5% (GC)

form

liquid

form

liquid

form

liquid

form

liquid

autoignition temp.

610 °F

autoignition temp.

610 °F

autoignition temp.

610 °F

autoignition temp.

610 °F

General description

Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms double hydrate with hydrogen sulfide, crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

Application

Dry tetrahydrofuran (THF) has been used in the synthesis of dichloro{bis[1,1′,1′′-(phosphinetriyl)tripiperidine]}palladium [(P(NC5H10)3)2Pd(Cl)2], which is widely used in the Heck reaction as a catalyst. It has been employed in the reaction medium of the Heck cross-coupling reaction of various aryl bromides and olefins.

Other Notes

Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (414247) and Cyclopentyl methyl ether (675970)

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-6.2 °F - closed cup

Flash Point(C)

-21.2 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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