39468

α-Cyano-4-hydroxycinnamic acid

matrix substance for MALDI-MS, Ultra pure

• Synonym(s): α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
• Linear Formula: HOC₆H₄CH=C(CN)CO₂H
• CAS Number: 28166-41-8
• Molecular Weight: 189.17
• Beilstein: 3271427
• EC Number: 248-879-1
• MDL number: MFCD00004204
• PubChem Substance ID: 329755873
• NACRES: NA.21

Properties

• grade: matrix substance for MALDI-MS
• Quality Level: 100
• form: solid
• analyte chemical class(es): glycans, peptides, proteins
• technique(s): MALDI-MS: suitable
• mp: 245-250 °C (lit.); 245-250 °C
• solubility: methanol: 10 mg/mL, clear
• cation traces: Al: ≤1 mg/kg; Ba: ≤1 mg/kg; Ca: ≤1 mg/kg; Cd: ≤1 mg/kg; Co: ≤1 mg/kg; Cr: ≤1 mg/kg; Cu: ≤1 mg/kg; Fe: ≤1 mg/kg; K: ≤1 mg/kg; Li: ≤1 mg/kg; Mg: ≤1 mg/kg; Mn: ≤1 mg/kg; Na: ≤1 mg/kg; Ni: ≤1 mg/kg; Pb: ≤1 mg/kg; Sr: ≤1 mg/kg; Zn: ≤1 mg/kg
• storage temp.: 2-8°C
• SMILES string: OC(=O)\C(=C\c1ccc(O)cc1)C#N
• InChI: 1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
• InChI key: AFVLVVWMAFSXCK-VMPITWQZSA-N

Description

General description

α-Cyano-4-hydroxycinnamic acid (α-CHCA) functions as matrix and helps in facilitating ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer.

Application

It was used as matrix in improving the detection of low concentration protein digests on MALDI-TOF.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H317 - H319 - H335
• Precautionary Statements: P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1B - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves