All Photos(1)

59924

Sigma-Aldrich

Polysorbate 80

tested according to Ph. Eur.

Synonym(s):
POE (20) sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polyethylene glycol sorbitan monooleate, TWEEN 80, Polysorbate 80, Polysorbatum 80
CAS Number:
MDL number:
NACRES:
NA.21

Quality Level

agency

USP/NF
tested according to Ph. Eur.

vapor pressure

<1 mmHg ( 20 °C)

description

non-ionic

mol wt

average mol wt 79,000

aggregation number

60

refractive index

n20/D 1.472 (lit.)

CMC

0.012

transition temp

cloud point 65 °C

density

1.064 g/mL at 25 °C (lit.)

HLB

15

application(s)

pharmaceutical (small molecule)

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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General description

Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.

Application

Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.

Biochem/physiol Actions

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

Priya N O Kasimbeg et al.
Journal of pharmaceutical sciences, 108(1), 155-161 (2018-10-14)
Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to
Enhancing the antibacterial efficacy of isoeugenol by emulsion encapsulation
Nielsen CK, et al.
International Journal of Food Microbiology, 229, 7-14 (2016)
Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin
Abdelaziz DM, et al.
Breast Cancer Research and Treatment, 143(2), 227-237 (2014)
Yuan Li et al.
Frontiers in microbiology, 11, 1450-1450 (2020-07-17)
Radiation therapy is a cornerstone of modern management methods for malignancies but is accompanied by diverse side effects. In the present study, we showed that food additives such as polysorbate 80 (P80) exacerbate irradiation-induced gastrointestinal (GI) tract toxicity. A 16S
Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
Hussein O, et al.
Cancer letters, 314(2), 176-184 (2012)

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