All Photos(3)




greener alternative

viscous liquid

POE (20) sorbitan monooleate, TWEEN® 80, Polyoxyethylenesorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polysorbate 80
CAS Number:
MDL number:

Quality Level




viscous liquid

mol wt

micellar avg mol wt 79.000
average mol wt 1310


Oleic acid, ≥58.0% (balance primarily linoleic, palmitic, and stearic acids)

greener alternative product characteristics

Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.


0.012 mM (20-25°C)

transition temp

cloud point 65 °C


1.064 g/cm3



greener alternative category




InChI key


General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a biobased surfactant and is aligned with the 7th principle of Green Chemistry "Use of Renewable Feedstocks" and the 10th principle "Design for Degradation".


TWEEN® 80 has been used in drug vehicle solution for specific injections in mice and rats. It has been used for the determination of esterase activity in bacterial cells.
Non-ionic detergent used for selective protein extraction and isolation of nuclei from mammalian cell lines.

Biochem/physiol Actions

TWEEN® 80 is a polysorbate surfactant which helps in stabilizing proteins and in protein membrane studies. It is regularly used for the extraction of membrane proteins and isolation of nuclei from cells.

Features and Benefits

  • 100 % Renewable
  • 100 % Bio-based
  • Certified to the USDA BioPreferred Program
  • Lower carbon footprint than petrochemical-based versions

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids



Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

> 113 °C - closed cup

Certificate of Analysis

Certificate of Origin

V Ryu et al.
Neuroscience, 167(4), 1227-1238 (2010-03-04)
Previous reports show that vagal afferent innervation of the stomach eventually regenerates from surviving nodose ganglion (NG) neurons after subdiaphragmatic vagotomy. Systemic capsaicin treatment destroys gastric vagal afferent neurons expressing vanilloid receptor 1 (VR1). However, it is not known whether
Eric R Rhodes et al.
Journal of virological methods, 228, 31-38 (2015-11-13)
The collection of waterborne pathogen occurrence data often requires the concentration of microbes from large volumes of water due to the low number of microorganisms that are typically present in environmental and drinking waters. Hollow-fiber ultrafiltration (HFUF) has shown promise
Thomas R Lerner et al.
The Journal of clinical investigation, 126(3), 1093-1108 (2016-02-24)
In extrapulmonary tuberculosis, the most common site of infection is within the lymphatic system, and there is growing recognition that lymphatic endothelial cells (LECs) are involved in immune function. Here, we identified LECs, which line the lymphatic vessels, as a
Martin L Cross et al.
Clinical and vaccine immunology : CVI, 16(9), 1378-1380 (2009-07-03)
Cultures of Mycobacterium bovis BCG, comprising predominantly single-cell bacilli, were prepared in broth without animal-derived reagents. When formulated into a vegetable-derived lipid matrix, the vaccine was stable in vitro and was immunogenic in vivo upon feeding it to mice. This
Cristina Marcos-Arias et al.
BMC complementary and alternative medicine, 11, 119-119 (2011-11-29)
Candida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils.

Related Content

Sustainable Chemistry

Our expanding portfolio of greener laboratory chemicals, programs and services support your sustainable chemistry lab work with less hazardous chemicals, biodegradable reagents and greener alternatives to help reduce waste and the environmental impact of chemistry.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service