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438081

Sigma-Aldrich

Phosphoric acid

greener alternative

ACS reagent, ≥85 wt. % in H2O

Synonym(s):
Orthophosphoric acid
Linear Formula:
H3PO4
CAS Number:
Molecular Weight:
98.00
Beilstein:
1921286
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

ACS reagent

vapor density

3.4 (vs air)

vapor pressure

2.2 mmHg ( 20 °C)
5 mmHg ( 25 °C)

assay

≥85% (with NaOH, titration)

form

liquid

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

concentration

≥85 wt. % in H2O

technique(s)

NMR: suitable

impurities

Reducing substances, passes test
≤0.001% volatile acids (as CH3COOH)

color

APHA: ≤10

bp

158 °C (lit.)

mp

~40 °C (lit.)

density

1.685 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤3 ppm
nitrate (NO3-): ≤5 ppm
sulfate (SO42-): ≤0.003%

cation traces

As: ≤1 ppm
Ca: ≤0.002%
Fe: ≤0.003%
K: ≤0.005%
Mg: ≤0.02%
Mn: ≤0.5 ppm
Na: ≤0.025%
Sb: ≤0.002%
heavy metals: ≤0.001% (by ICP)

greener alternative category

Enabling

SMILES string

OP(O)(O)=O

InChI

1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)

InChI key

NBIIXXVUZAFLBC-UHFFFAOYSA-N

Gene Information

human ... SRC(6714)

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here.
Phosphoric acid (H3PO4), also known as orthophosphoric acid, is an inorganic acid. It has a wide range of industrial applications such as an intermediate to produce animal feedstock, to prepare stock solutions for workup procedures and to treat the metal surfaces for better adhesion of paint and resin coatings. In the food industry it is used as a preservative, an acidulant and flavor enhancer.

Application

Phosphoric acid may be employed as standard for the determination of phosphorus-31 nuclear magnetic resonance (31P NMR) chemical shifts of the common phospholipids. It may be employed in the following studies:
  • As external standard for the analysis of lipid composition of human white matter by 31P NMR spectroscopy.
  • As external standard during the acid-labile phosphorylation of histone H4 by 31P NMR spectroscopy.
  • As reference standard to investigate the surface species present on silica/alumina-supported sodium phosphates by pre- and postreaction MAS31P-NMR and FTIR spectroscopies.
  • As catalyst in the vapor-phase Fries rearrangement of phenylacetate at 623K over a series of surface modified and unmodified ZSM-5.
  • As an eco-friendly reagent for the removal of protecting groups like tert-butyl carbamates, tert-butyl esters and tert-butyl ethers.

Packaging

500, 6×500 mL in PVC-coated bottle
2.5, 6×2.5 L in PVC-coated bottle

Other Notes

Concentrated phosphoric acid is approx. 85% H3PO4 (aqueous).

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Aqueous phosphoric acid as a mild reagent for deprotection of tert-butyl carbamates, esters, and ethers.
Li B, et al.
The Journal of Organic Chemistry, 71(24), 9045-9050 (2006)
Myers RL.
The 100 Most Important Chemical Compounds: A Reference Guide, 220-220 (2007)
A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces.
Buonocore MG.
Journal of Dental Research, 34(6), 849-853 (1955)
Internal versus external surface active sites in ZSM-5 zeolite: Part 1. Fries rearrangement catalyzed by modified and unmodified H3PO4/ZSM-5.
Ghiaci M, et al.
Applied Catalysis A: General, 298, 32-39 (2006)
FTIR and 31 P-NMR spectroscopic analyses of surface species in phosphate-catalyzed lactic acid conversion.
Gunter GC, et al.
J. Catal., 164(1), 207-219 (1996)

Protocols

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This application illustrate how Rutin can be determined in skin cream samples using a monolithic Chromolith® HighResolution RP-18 endcapped column with UV detection.

Enzymatic Assay of Alcohol Dehydrogenase (EC 1.1.1.1)

This procedure may be used for Alcohol Dehydrogenase products.

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