A6283

Acetic acid

glacial, ReagentPlus^®, ≥99%

• Synonym(s): Glacial acetic acid
• Linear Formula: CH₃CO₂H
• CAS Number: 64-19-7
• Molecular Weight: 60.05
• Beilstein: 506007
• EC Number: 200-580-7
• MDL number: MFCD00036152
• PubChem Substance ID: 329770889
• NACRES: NA.21

Properties

• vapor density: 2.07 (vs air)
• Quality Level: 200
• product line: ReagentPlus^®
• Assay: ≥99%
• form: liquid
• autoignition temp.: 800 °F
• expl. lim.: 16 %, 92 °F; 4 %, 59 °F
• refractive index: n20/D 1.371 (lit.)
• pH: 2.5 (20 °C, 50 g/L)
• bp: 117-118 °C (lit.)
• mp: 16.2 °C (lit.)
• solubility: alcohol: miscible(lit.); carbon disulfide: insoluble(lit.); glycerol: miscible(lit.); water: miscible(lit.)
• density: 1.049 g/mL at 25 °C (lit.)
• storage temp.: room temp
• SMILES string: CC(O)=O
• InChI: 1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)
• InChI key: QTBSBXVTEAMEQO-UHFFFAOYSA-N

Description

General description

Acetic acid is an aliphatic organic acid. It is a hygroscopic, corrosive liquid with a vinegar-like odor. It can be synthesized by oxidizing acetaldehyde in the presence of manganese or cobalt salts. It is utilized for synthesizing acetic anhydride, cellulose acetate and acetic esters. Its impact on the degradation of historic paper has been analyzed.

Application

Acetic acid (AcOH) can be used as:      

• A reaction solvent in many organic reactions such as bromination, hydrolysis, solvolysis, reductions, and hydrogenations.      
• A reagent in the protonolysis of organometallic compounds.
• An acetylating agent for the acetylation of electron-rich aromatic compounds.      
• A catalyst to synthesize di(indolyl)methanes by the condensation reaction of indole and aromatic aldehydes.      
• A solvent system to prepare 3,4-dihydropyrimidin-2(1H)-one derivative via Biginelli reaction of aromatic aldehydes, 1,3-dicarbonyl compounds, and urea in the presence of a boric acid catalyst.

Acetic acid can also be used in the following:     

• Manganese(III) acetate/AcOH catalytic system is used in the conversion of alkenes to lactones.      
• Iron salts/AcOH is used to oxidize 2-methylnaphthalene to 2-methyl-1-naphthol in the presence of H₂O₂.

Features and Benefits

• Good stability towards many reagents     
• Excellent solubility of organic compounds in this reagent

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H226 - H314
• Precautionary Statements: P210 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 102.2 °F
• Flash Point(C): 39 °C