Merck
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C9008

Sigma-Aldrich

p-Coumaric acid

≥98.0% (HPLC)

Synonym(s):
trans-4-Hydroxycinnamic acid
Linear Formula:
HOC6H4CH=CHCO2H
CAS Number:
Molecular Weight:
164.16
Beilstein:
2207383
MDL number:
PubChem Substance ID:
NACRES:
NA.47

assay

≥98.0% (HPLC)

form

powder

mp

214 °C (dec.) (lit.)

solubility

ethanol: 50 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OC(=O)\C=C\c1ccc(O)cc1

InChI

1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+

InChI key

NGSWKAQJJWESNS-ZZXKWVIFSA-N

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Application

p-Coumaric acid has been used as a component of chemiluminescent substrate for protein detection in western blotting.

Packaging

1, 5, 10, 25 g in poly bottle

Biochem/physiol Actions

p-Coumaric acid is mainly a plant metabolite which exhibits antioxidant and anti-inflammatory properties. It also shows bactericidal activity by damaging bacterial cell membrane and by interacting with bacterial DNA. In western blot, p-coumaric is also used as an enhancer in chemiluminescent substrate.
Hydroxycinnamic acid found in many fruits and vegetables.

Other Notes

Predominantly trans isomer.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Enhanced chemiluminescence (ECL) for routine immunoblotting: An inexpensive alternative to commercially available kits.
Mruk DD and Cheng CY
Spermatogenesis, 1, 121-122 (2011)
p-Coumaric acid kills bacteria through dual damage mechanisms.
Zaixiang L, et al.
Food Control, 25, 550-554 (2012)
Inflammation triggers high mobility group box 1 (HMGB1) secretion in adipose tissue, a potential link to obesity.
Gunasekaran MK, et al.
Cytokine, 64, 103-111 (2013)
A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background.
Haan C and Behrmann I
Journal of Immunological Methods, 318, 11-11 (2007)
TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta.
Rojas A, et al.
Biochimica et Biophysica Acta, 1793, 1165-1173 (2009)

Protocols

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

HPLC Analysis of Flavonoids on Ascentis® RP-Amide

Protocol for HPLC Analysis of Flavonoids on Ascentis® RP-Amide

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