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G2879

Sigma-Aldrich

Glycine hydrochloride

≥99% (HPLC)

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Synonym(s):
Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll
Linear Formula:
H2NCH2CO2H · HCl
CAS Number:
Molecular Weight:
111.53
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.32

Quality Level

Assay

≥99% (HPLC)

form

powder

mol wt

111.53

storage condition

(Tightly closed Dry)

concentration

≤100%

technique(s)

immunohistochemistry: suitable

mp

176-180 °C (lit.)

solubility

water: 0.5 g/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl.NCC(O)=O

InChI

1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H

InChI key

IVLXQGJVBGMLRR-UHFFFAOYSA-N

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1 of 4

This Item
PHG0016G712615527
Glycine hydrochloride ≥99% (HPLC)

G2879

Glycine hydrochloride

-
Glycine hydrochloride

PHG0016

Glycine hydrochloride

-
Glycine ReagentPlus®, ≥99% (HPLC)

G7126

Glycine

-
Glycine meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)

15527

Glycine

Essential Grade
assay

≥99% (HPLC)

assay

-

assay

≥99% (HPLC)

assay

99-101% (based on anhydrous substance)

form

powder

form

powder

form

powder

form

crystalline powder

mol wt

111.53

mol wt

-

mol wt

-

mol wt

-

storage condition

(Tightly closed Dry)

storage condition

-

storage condition

-

storage condition

-

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

-

General description

Research area: Neuroscience

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Glycine hydrochloride has been used:
  • in the preparation of glycine-HCl buffer
  • to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
  • to regenerate the sensor to elute the bound C-reactive protein (CRP)

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

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Pricing

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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ReBlot Plus Kit

Millipore

2500

ReBlot Plus Kit

Zipei Feng et al.
Journal of immunology (Baltimore, Md. : 1950), 196(9), 3943-3950 (2016-03-20)
Recent advances in multiplex immunohistochemistry techniques allow for quantitative, spatial identification of multiple immune parameters for enhanced diagnostic and prognostic insight. However, applying such techniques to murine fixed tissues, particularly sensitive epitopes, such as CD4, CD8α, and CD19, has been
M D Wheeler et al.
Cellular and molecular life sciences : CMLS, 56(9-10), 843-856 (2001-02-24)
The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes.
Glycine
Hall JC
JPEN. Journal of parenteral and enteral nutrition, 22(6), 393-398 (2019)
Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays
Ingale J and Wyatt RT
Bio-protocol, 5(20) (2015)
Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection
Thies JW, et al.
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Protocols

This page shows and discusses three protocols for stripping and reprobing a western blot membrane.

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