Merck
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I9279

Sigma-Aldrich

Interleukin-11 from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(s):
IL-11
MDL number:
NACRES:
NA.32

biological source

mouse

Quality Level

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

predicted mol wt ~19 kDa

packaging

pkg of 5 μg

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Il11(16156)

Biochem/physiol Actions

Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.

Physical form

Lyophilized from a 20.0 μL of a 0.2 μm filtered solution in phosphate buffered saline, pH 7.3, with 5% trehalose and with 50 μg bovine serum albumin per 1μg as a carrier protein.

Analysis Note

Assayed in a cell proliferation assay using T11 cells, a subline of the IL-6 dependent mouse plasmacytoma cell line T1165.85.2, that has been adapted to grow in IL-11.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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SDS

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