Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.
Lyophilized from a 20.0 μL of a 0.2 μm filtered solution in phosphate buffered saline, pH 7.3, with 5% trehalose and with 50 μg bovine serum albumin per 1μg as a carrier protein.
Assayed in a cell proliferation assay using T11 cells, a subline of the IL-6 dependent mouse plasmacytoma cell line T1165.85.2, that has been adapted to grow in IL-11.