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L8134

Sigma-Aldrich

Linoleic acid sodium salt

≥98% (GC)

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Synonym(s):
Sodium linolate, Sodium linoleate, cis-9,cis-12-Octadecadienoic acid sodium salt
Linear Formula:
C18H31O2Na
CAS Number:
Molecular Weight:
302.43
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

biological source

plant oil (safflower)

Quality Level

Assay

≥98% (GC)

form

powder

technique(s)

activity assay: suitable

color

white

mp

230 °C (446 °F)

solubility

methanol: 50 mg/mL, clear, yellow

application(s)

general analytical
life science and biopharma

functional group

carboxylic acid

lipid type

omega FAs

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na+].CCCCC\C=C/C\C=C/CCCCCCCC([O-])=O

InChI

1S/C18H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20);/q;+1/p-1/b7-6-,10-9-;

InChI key

WYPBVHPKMJYUEO-NBTZWHCOSA-M

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This Item
L1376L1012L2376
Linoleic acid sodium salt ≥98% (GC)

L8134

Linoleic acid sodium salt

Linoleic acid ≥99%

L1376

Linoleic acid

Linoleic acid liquid, BioReagent, suitable for cell culture

L1012

Linoleic acid

Linolenic acid ≥99%

L2376

Linolenic acid

assay

≥98% (GC)

assay

≥99%

assay

≥99%

assay

≥99%

technique(s)

activity assay: suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

biological source

plant oil (safflower)

biological source

plant oil (safflower)

biological source

plant (Safflower oil)

biological source

-

form

powder

form

liquid

form

liquid

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Linoleic acid, an essential omega-6 polyunsaturated fatty acid (PUFA), serves as a precursor to arachidonic acid (AA), necessary for synthesizing prostaglandins and other eicosanoids. Being an essential fatty acid, linoleic acid must be acquired through diet as the body cannot produce it. Deficiencies in linoleic acid are linked to health issues such as impaired wound healing, growth retardation, and dermatitis. Arachidonate 15 Lipoxygenase (15-LO) metabolizes linoleic acid in both plants and animals, forming 9- and 13-hydroxyoctadecadienoic acid (HODE). This versatile molecule finds applications in biochemical, metabolomics, and lipidomics research, enabling investigations into various metabolic pathways and providing insights into lipid functions in living organisms.

Application

Linoleic acid sodium salt has been used:
  • in the β-carotene-linoleic acid assay
  • as a component in basal medium to treat peripheral blood mononuclear cells (PBMCs)
  • in Dulbecco′s modified Eagle′s medium (DMEM)/F-12 HEPES (4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) to incubate human trophoblast-derived choriocarcinoma cells (BeWo) and study its effects on adherens junctions (AJ) marker level, cell layer permeability, and intracellular lipid accumulation

Biochem/physiol Actions

Linoleic acid, as a component of acylglycosyl ceramides, plays a physiological role in maintaining the water permeability barrier of the skin. The deficiency of linoleic acid may cause poor growth or development, scaly dermatitis, and an impaired immune response in infants. It is used in cosmetic and personal care products. Linoleic acid is mainly used as emollients or moisturizers for skin, nails, and hair.

Features and Benefits

  • High-quality molecule suitable for mulitple research applications
  • Commonly employed in Metabolomics and Biochemical studies

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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