SML0142

Valsartan

≥98% (HPLC), Angiotensin II type 1 (AT1) receptor antagonist, powder

• Synonym(s): N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine
• Empirical Formula (Hill Notation): C₂₄H₂₉N₅O₃
• CAS Number: 137862-53-4
• Molecular Weight: 435.52
• MDL number: MFCD00865840
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825190
• NACRES: NA.77

Properties

• Product Name: Valsartan, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -55 to -70°, c = 1 in methanol
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥20 mg/mL
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
• InChI: 1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
• InChI key: ACWBQPMHZXGDFX-QFIPXVFZSA-N
• Gene Information: human ... AGTR1(185)

Description

Application

Mice were treated with valsartan to study the role of Ang II-dependent pathway in aldosterone-related effects.[1]

Biochem/physiol Actions

Valsartan is an Angiotensin II type 1 (AT1) receptor antagonist and anti-hypertensive. Valsartan renders protection against heart attack and stroke resulting from abrupt increase in blood pressure.[2] Valsartan reduces myocardial-infarction-related complications in heart attack survivors.[3]

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H336,H361d
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Repr. 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable