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Clarification Depth Filters & Pretreatment Solutions

Our clarification portfolio provides flexibility to the biopharma manufacturer for efficient cell, cellular debris and other insoluble contaminant removal and impurity clearance from different process streams from process development through large-scale manufacturing. Millistak+®, Millistak+® HC Pro and Clarisolve® Depth filters are available in Pod devices.

Millistak+® HC Pro Filters

Millistak+® HC Pro Filters

MILLISTAK+® HC PRO FILTERS

These are high capacity fully synthetic depth filters for primary and secondary clarification and downstream polishing applications.

Millistak+® Depth Filters

Millistak+® Depth Filters

Millistak+® Depth Filters

These filters are offered in both Pod and lenticular formats.

  • Millistak+® HC filters combine multiple layers of charged depth media for enhanced particulate retention and filter capacity for clarification and polishing applications.
  • Millistak+® Carbon offers enhanced impurity clearance for turbidity reduction and polishing.
  • Millistak+® DE filters are single layer clarification filters containing diatomaceous earth and a charged resin binder.
  • Millistak+® CE filters are single layer clarification filters containing cellulose.
Clarisolve® depth filters and polymers

Clarisolve® Depth Filters and Flocculation Polymers

Clarisolve® depth filters offer a gradient density structure designed for efficient primary clarification of pretreated cell culture harvests.

  • pDADMAC (poly(diallyldimethyl-ammonium chloride) is a cationic polymer for flocculation of cellular debris.

Support for Qualification, Risk Assessment, and Process Optimization

Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.

Find the right filter for your application.


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Highlights

Best Practices for Process Development Using Small-scale Millistak+®
Webinar: Best Practices for Process Development Using Small-scale Millistak+® Filters

How to standardize the process development approach for a two-step clarification process ensuring development of a robust, scalable unit operation.

Clarification of Mammalian Cell Culture Feed Streams
Webinar: Clarification of Mammalian Cell Culture Feed Streams Using a Cationic Flocculant, pDADMAC, and Clarisolve® Depth Filters

pDADMAC for pretreatment of mammalian cell culture harvest utilizing Clarisolve® depth filters for improved primary & secondary clarification of flocculated feeds.

Flow-through Chromatography and Adsorptive Depth Filtration for Continuous Bioprocessing Applications
Webinar: Flow-through Chromatography and Adsorptive Depth Filtration for Continuous Bioprocessing Applications

Join to hear case studies on effective separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing mAbs.