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Meseret Ashenafi et al.
Molecular and cellular biochemistry, 400(1-2), 9-15 (2014-10-31)
Recently, we showed that the fused chorismate-utilizing enzyme from the antibiotic-producing soil bacterium Streptomyces venezuelae is an anthranilate synthase (designated SvAS), not a 2-amino-2-deoxyisochorismate (ADIC) synthase, as was predicted based on its amino acid sequence similarity to the phenazine biosynthetic
Hiroko Asahi et al.
BMC microbiology, 14, 167-167 (2014-06-26)
Malaria continues to be a devastating disease. The elucidation of factors inducing asexual growth versus arrest of Plasmodium falciparum can provide information about the development of the parasite, and may help in the search for novel malaria medication. Based on
Ho-Youn Kim et al.
Plant science : an international journal of experimental plant biology, 231, 30-39 (2015-01-13)
During ripening fruits undergo several physiological and biochemical modifications that influence quality-related properties, such as texture, color, aroma and taste. We studied the differences in ethylene and sugar metabolism between two genetically related Japanese plum cultivars with contrasting ripening behaviors.
Joshua Russell et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(22), 8269-8274 (2014-05-21)
All terrestrial animals must find a proper level of moisture to ensure their health and survival. The cellular-molecular basis for sensing humidity is unknown in most animals, however. We used the model nematode Caenorhabditis elegans to uncover a mechanism for
Shahram Attarian et al.
Orphanet journal of rare diseases, 9, 199-199 (2014-12-19)
Charcot-Marie-Tooth type 1A disease (CMT1A) is a rare orphan inherited neuropathy caused by an autosomal dominant duplication of a gene encoding for the structural myelin protein PMP22, which induces abnormal Schwann cell differentiation and dysmyelination, eventually leading to axonal suffering
Clinical relevance of adaptation to sorbitol by plaque bacteria: a review.
W H Bowen
The Journal of clinical dentistry, 7(1), 1-5 (1996-01-01)
Camille Desgrouas et al.
Malaria journal, 13, 327-327 (2014-08-26)
New classes of anti-malarial drugs are needed to control the alarming Plasmodium falciparum resistance toward current anti-malarial therapy. The ethnopharmacological approach allows the discovery of original chemical structures from the vegetable biodiversity. Previous studies led to the selection of a
Zhengming Gu et al.
Archives of pathology & laboratory medicine, 138(11), 1474-1480 (2014-10-31)
Invasive fungal infections are an important cause of morbidity and mortality among immunocompromised patients. To design and evaluate a multiplexed assay aimed at quantitative detection and differentiation of the 5 molds that are most commonly responsible for pulmonary infections. Using
Selina Kern et al.
PloS one, 9(9), e105732-e105732 (2014-09-05)
Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate Serine/Arginine-rich (SR) proteins involved in pre-mRNA processing. Four CLKs, termed PfCLK-1-4, can be identified in the human malaria parasite Plasmodium falciparum, which show homology with the yeast SR protein
G Molino et al.
The Journal of laboratory and clinical medicine, 131(5), 393-405 (1998-05-30)
D-Sorbitol (SOR) is safe, is easy to measure, and has an exceptionally high extraction ratio in the normal liver of 0.93+/-0.05 (mean+/-SD). Together with the general interest in hepatic hemodynamics, these facts motivated us to review the usefulness of this
John-Max Mongkhon et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(8), 691-701 (2014-05-27)
Our study was designed to elucidate the precise molecular mechanisms by which sorbitol-modified hyaluronic acid (HA/sorbitol) exerts beneficial effects in osteoarthritis (OA). Human OA chondrocytes were treated with increasing doses of HA/sorbitol ± anti-CD44 antibody or with sorbitol alone and thereafter with
Yoichi Ishii et al.
Biological & pharmaceutical bulletin, 38(2), 306-316 (2014-12-17)
Cell culture processes that produce therapeutic antibodies with high productivity (titer) and low aggregate content reduce the risk of adverse effects and expense to patients. To elucidate the mechanism of aggregate formation, we compared trastuzumab samples produced from two contrasting
Sabine Bélard et al.
Infection, 43(2), 177-183 (2014-11-29)
Group A streptococcus (GAS) and possibly other β-hemolytic streptococci (BHS) account for a considerable morbidity and mortality burden in African populations; however, disproportionately little is known about the epidemiology of BHS in sub-Saharan Africa. This study assessed the prevalence of
Nicolli B de Souza et al.
Malaria journal, 13, 469-469 (2014-12-03)
Given the threat of resistance of human malaria parasites, including to artemisinin derivatives, new agents are needed. Chloroquine (CQ) has been the most widely used anti-malarial, and new analogs (CQAns) presenting alkynes and side chain variations with high antiplasmodial activity
Samadhi Aparicio-Siegmund et al.
Oncotarget, 5(8), 2131-2148 (2014-04-20)
The Janus kinase / signal transducer and activator of transcription (Jak/STAT) pathway can be activated by many different cytokines, among them all members of the Interleukin (IL-)6 family. Dysregulation of this pathway, resulting in its constitutive activation, is associated with
Chao Zhang et al.
PloS one, 9(7), e103456-e103456 (2014-07-30)
Scorpine, a small cationic peptide from the venom of Pandinus imperator, which has been shown to have anti-bacterial and anti-plasmodial activities, has potential important applications in the pharmaceutical industries. However, the isolation of scorpine from natural sources is inefficient and
Umakant Sahu et al.
Biochemical and biophysical research communications, 451(1), 158-164 (2014-08-05)
The zinc finger transcription factors Mxr1p and Rop are key regulators of methanol metabolism in the methylotrophic yeast, Pichia pastoris, while Trm1p and Trm2p regulate methanol metabolism in Candida boidinii. Here, we demonstrate that Trm1p is essential for the expression
Yi-Hsun Huang et al.
PloS one, 10(3), e0122491-e0122491 (2015-03-31)
To determine the role of thrombomodulin (TM) in corneal epithelial wound healing, and to investigate whether recombinant TM epidermal growth factor-like domain plus serine/threonine-rich domain (rTMD23) has therapeutic potential in corneal epithelial wound healing. TM localization and expression in the
Brian A Burt
Journal of the American Dental Association (1939), 137(2), 190-196 (2006-03-09)
The author compared the caries-inhibitory action of sorbitol- and xylitol-sweetened chewing gum and assessed the role of these products in caries prevention. The author reviewed studies including randomized field trials with substantial numbers of participants and observational studies. He did
Haisong Wang et al.
Carbohydrate polymers, 113, 225-230 (2014-09-27)
Microwave irradiation is a rapid and efficient method to synthesize oligomers and can be employed in polysaccharides production. As an artificial polysaccharide, polydextrose is known for its solid performance in food processing and its additional health benefits. This study was
Cora Lilia Alvarez et al.
PloS one, 9(5), e96216-e96216 (2014-05-27)
In human erythrocytes (h-RBCs) various stimuli induce increases in [cAMP] that trigger ATP release. The resulting pattern of extracellular ATP accumulation (ATPe kinetics) depends on both ATP release and ATPe degradation by ectoATPase activity. In this study we evaluated ATPe
Sharon Wein et al.
Antimicrobial agents and chemotherapy, 58(9), 5519-5527 (2014-07-09)
Bis-thiazolium salts constitute a new class of antihematozoan drugs that inhibit parasite phosphatidylcholine biosynthesis. They specifically accumulate in Plasmodium- and Babesia-infected red blood cells (IRBC). Here, we provide new insight into the choline analogue albitiazolium, which is currently being clinically
Arlette Bochud et al.
Biochimica et biophysica acta, 1851(5), 629-640 (2015-02-18)
Five yeast enzymes synthesizing various glycerophospholipids belong to the CDP-alcohol phosphatidyltransferase (CAPT) superfamily. They only share the so-called CAPT motif, which forms the active site of all these enzymes. Bioinformatic tools predict the CAPT motif of phosphatidylinositol synthase Pis1 as
Deepak Yadav et al.
International journal of pharmaceutics, 477(1-2), 564-577 (2014-12-03)
The present work aims to investigate applicability of antisolvent precipitation method for preparation of nanosized curcumin and to control their characteristics by determining the influence of process and solvents on solid-state properties of curcumin nanoparticles. Effects of different experimental parameters
Jianying Huang et al.
Brain : a journal of neurology, 137(Pt 6), 1627-1642 (2014-04-30)
Sodium channel Nav1.9 is expressed in peripheral nociceptive neurons, as well as visceral afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy represents a significant public health challenge and may involve gain-of-function variants in sodium
Papa Alioune Ndour et al.
The Journal of infectious diseases, 211(2), 290-297 (2014-09-04)
In Plasmodium falciparum-infected patients treated with artemisinins, parasitemia declines through so-called pitting, an innate splenic process that transforms infected red blood cells (iRBCs) into once-infected RBCs (O-iRBCs). We measured pitting in 83 French travelers and 42 Malian children treated for
M Tokuda et al.
Connective tissue research, 56(1), 44-49 (2014-11-06)
To examine the responses of mouse odontoblast-lineage cell line (OLC) cultures to xylitol-induced hypertonic stress. OLCs were treated with xylitol, sucrose, sorbitol, mannitol, arabinose and lyxose. Cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium assay. The expression of transient receptor
Raquel dos Santos et al.
Journal of chromatography. A, 1355, 115-124 (2014-06-21)
In this work, phenylboronic acid (PBA) was thoroughly investigated as a synthetic ligand for the purification of an immunoglobulin G (IgG) from a clarified cell supernatant from Chinese Hamster Ovary (CHO) cell cultures. In particular, the study was focused on
Edward Sisco et al.
The Analyst, 140(8), 2785-2796 (2015-02-27)
This work highlights the rapid detection of nitrate ester explosives and their sugar alcohol precursors by direct analysis in real time mass spectrometry (DART-MS) using an off-axis geometry. Demonstration of the effect of various parameters, such as ion polarity and
Antoine Sadiki Kishabongo et al.
PloS one, 10(3), e0120112-e0120112 (2015-03-18)
Although assessment of glycated nail proteins may be a useful marker for monitoring of diabetes, their nature and formation are still poorly understood. Besides a detailed anatomical analysis of keratin glycation, the usefulness of glycated nail protein assessment for monitoring
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