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Timo Heidt et al.
Circulation research, 115(2), 284-295 (2014-05-03)
Macrophages populate the steady-state myocardium. Previously, all macrophages were thought to arise from monocytes; however, it emerged that, in several organs, tissue-resident macrophages may self-maintain through local proliferation. Our aim was to study the contribution of monocytes to cardiac-resident macrophages
Raúl González-Domínguez et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2395-2402 (2014-10-05)
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its etiology is still not completely understood. The identification of underlying pathological mechanisms is becoming increasingly important for the discovery of biomarkers and therapies, for which metabolomics presents a
Fatima El Aamri et al.
Microbes and infection, 17(4), 258-265 (2014-06-24)
Streptococcus iniae has become one of the most serious aquatic pathogens in the last decade, causing large losses in wild and farmed fish worldwide. There is clear evidence that this pathogen is capable not only of causing serious disease in
Lingfang Zhu et al.
Antonie van Leeuwenhoek, 107(4), 1001-1008 (2015-01-28)
A yellow-pigmented bacterium, designated strain GZGR-4(T), was isolated from the root of Hylomecon japonica (Thunb.) Prantl et Kündig collected from Taibai Mountain in Shaanxi Province, north-west China. Cells of strain GZGR-4(T) were Gram-negative, rod-shaped, strictly aerobic, non-endospore-forming and non-motile. Phylogenetic
Manoochehr Rasekh et al.
International journal of pharmaceutics, 473(1-2), 95-104 (2014-07-06)
A method in layering dressings with a superficial active layer of sub-micrometer scaled fibrous structures is demonstrated. For this, polyvinylpyrolidone (PVP)-indomethacin (INDO) fibres (5% w/v PVP, 5% w/w indomethacin, using a 50:50 ethanol-methanol solvent system) were produced at different flow
Jean M Parry et al.
Development (Cambridge, England), 141(22), 4279-4284 (2014-11-06)
Receptor tyrosine kinase (RTK) signaling through Ras influences many aspects of normal cell behavior, including epithelial-to-mesenchymal transition, and aberrant signaling promotes both tumorigenesis and metastasis. Although many such effects are cell-autonomous, here we show a non-cell-autonomous role for RTK-Ras signaling
Karen E Beech et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 247-254 (2015-08-09)
Lyophilized protein formulations must be reconstituted back into solution prior to patient administration and in this regard long reconstitution times are not ideal. The factors that govern reconstitution time remain poorly understood. The aim of this research was to understand
Chiyo Kitayama et al.
The Journal of reproduction and development, 61(5), 415-421 (2015-06-23)
The structure and functions of placentas were examined in 3 species of rorqual whales, common minke (Balaenoptera acutorostrata), Bryde's (B. brydei) and sei (B. borealis) whales, with the aim of confirming the structural characteristics of the chorion, including the presence
Edyta Nalewajko-Sieliwoniuk et al.
Talanta, 133, 38-44 (2014-12-02)
The first method for the simultaneous determination of polyphenolic antioxidants in extracts from leaves of Cirsium palustre based on high performance liquid chromatography combined with flow injection chemiluminescence detection (HPLC-FI-CL) has been developed. The extracts were prepared by using methanol
Ravi Tharakan et al.
Journal of proteome research, 14(3), 1621-1626 (2015-01-13)
Metabolomics and peptidomics are systems biology approaches in which broad populations of molecular species produced in a cell or tissue sample are identified and quantified. These two molecular populations, metabolites and peptides, can be extracted from tissues in a similar
Shilpa Raut et al.
Journal of pharmaceutical and biomedical analysis, 109, 121-127 (2015-03-15)
We are reporting a new methodology of using Raman spectroscopy for studying the drug surfactant interactions in self-emulsifying drug delivery systems (SEDDS). The physicochemical properties of surfactants could affect the performance of drugs from lipid delivery systems. Thus the purpose
Zhongqiang Guo et al.
Oncology reports, 33(3), 1519-1525 (2015-01-13)
Prostate cancer is a leading cause of cancer-related death among men. Early diagnosis and treatment are successful against prostate cancer, yet the clinical treatment of advanced prostate cancer remains a challenge. Gemcitabine is used to treat a broad spectrum of
Krista L Niece et al.
Antimicrobial agents and chemotherapy, 59(9), 5542-5547 (2015-07-01)
Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing
Tibor Bartók et al.
Journal of chromatographic science, 52(6), 508-513 (2013-06-12)
Five previously unknown fumonisin mycotoxins (iso-FP1, iso-FP(2,3a), iso-FP(2,3b), FP4 and iso-FP4) and three previously described FP analogues (FP(1-3)) were detected in a solid rice culture inoculated with Fusarium verticillioides. The fumonisins were characterized by high-performance liquid chromatography-electrospray ionization time-of-flight mass
Mohamed Dawoud
Drug development and industrial pharmacy, 41(1), 156-162 (2013-10-30)
Due to their small particle size, colloidal fat emulsions are suitable for intravenous administration. In order to obtain information on their potential in vivo performance, it is important to find a simple and effective in vitro assay to evaluate the
Hua Tian et al.
Journal of lipid research, 55(9), 1970-1980 (2014-05-24)
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging has been used for the direct analysis of single intact Xenopus laevis embryo surfaces, locating multiple lipids during fertilization and the early embryo development stages with subcellular lateral resolution (∼4 μm). The method
Xiaohui Xu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 33(5), 1272-1282 (2014-05-08)
In Chinese culture, the roots of Averrhoa carambola L. have long been used for medical purposes due to their potent pharmaceutical activities, such as improving digestive function and treating diabetes. Recently, we prepared extracts of Averrhoa carambola L. root (EACR)
Chester E Chamberlain et al.
The Journal of clinical investigation, 124(9), 4093-4101 (2014-08-19)
Endocrine cell proliferation fluctuates dramatically in response to signals that communicate hormone demand. The genetic alterations that override these controls in endocrine tumors often are not associated with oncogenes common to other tumor types, suggesting that unique pathways govern endocrine
Rosalind M K Stewart et al.
Investigative ophthalmology & visual science, 56(3), 2021-2030 (2015-02-28)
The conjunctiva plays a key role in ocular surface defence and maintenance of the tear film. Ex vivo expansion of conjunctival epithelial cells offers potential to reconstruct the ocular surface in cases of severe cicatrising disease, but requires initial biopsies
D K Dastur et al.
The British journal of nutrition, 36(2), 143-159 (1976-09-01)
1. The B-vitamin status of fifty-nine patients, mainly from the lower socio-economic classes in Bombay, with a history of chronic malnutrition, and of alcoholism of 1-5-20 years' duration, was studied before and during treatment, and in relation to their clinical
Wan Cao et al.
Journal of chromatography. A, 1390, 13-21 (2015-03-10)
This report describes the use of trace-chitosan-wrapped multi-walled carbon nanotubes (CS-MWCNTs) as a sorbent material in dispersive micro solid-phase extraction (DMSPE), which was combined with ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry to analyze phenolic compounds in
Leslie A Mitchell et al.
The American journal of pathology, 185(2), 372-386 (2014-12-02)
Epithelial barrier function is maintained by tight junction proteins that control paracellular fluid flux. Among these proteins is junctional adhesion molecule A (JAM-A), an Ig fold transmembrane protein. To assess JAM-A function in the lung, we depleted JAM-A in primary
Yaping Zhang et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(8), 667-673 (2014-10-31)
Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly
Toshiaki Makino et al.
Journal of natural medicines, 68(3), 505-512 (2014-02-21)
Gypsum is a crude mineral drug used in the formulas of Japanese kampo medicine and traditional Chinese medicine. The present study aimed to evaluate the anti-allergic effect of byakkokakeishito extract (BKT), which consists of gypsum (natural hydrous calcium sulfate), Anemarrhena
Efrem T Abay et al.
Malaria journal, 14, 8-8 (2015-01-08)
Even though malaria is a completely preventable and treatable disease, it remains a threat to human life and a burden to the global economy due to the emergence of multiple-drug resistant malaria parasites. According to the World Malaria Report 2013
Junh-Hoon Kim et al.
Molecular medicine reports, 10(6), 3035-3046 (2014-10-18)
Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water
Corinna Diegelmann et al.
Journal of basic microbiology, 55(11), 1245-1254 (2015-07-02)
A novel mesophilic bacterial strain, designated A-1, was isolated from microbially contaminated biopolymer microcapsules. The bacterium was able to withstand and grow in liquid cultures supplemented with the pyrethroid cypermethrin in concentrations up to 400 mg L(-1) . Furthermore, strain A-1 could
Aurélie Mallinger et al.
Journal of medicinal chemistry, 58(4), 1717-1735 (2015-02-14)
WNT signaling is frequently deregulated in malignancy, particularly in colon cancer, and plays a key role in the generation and maintenance of cancer stem cells. We report the discovery and optimization of a 3,4,5-trisubstituted pyridine 9 using a high-throughput cell-based
Paul M Flanigan et al.
Journal of the American Society for Mass Spectrometry, 26(5), 716-724 (2015-03-01)
The internal energy of p-substituted benzylpyridinium ions after laser vaporization using low energy, femtosecond duration laser pulses of wavelengths 800 and 1042 nm was determined using the survival yield method. Laser vaporization of dried benzylpyridinium ions from metal slides into a
Vishal D Shah et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(6), 799-802 (2015-12-04)
During the acclimation phase of a preclinical safety study involving Syrian golden hamsters, some of the cages of treatment-naïve animals were noted to contain blue-tinged bedding; the urine of these hamsters was not discolored. We sought to understand the underlying
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