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Xabier Osteikoetxea et al.
PloS one, 10(3), e0121184-e0121184 (2015-03-24)
In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and quantification of extracellular vesicles as well as better standards to
Mustafa Demirci et al.
Clinical oral investigations, 19(9), 2187-2199 (2015-03-25)
To evaluate the medium-term clinical performance of direct composite build-ups for diastema closures and teeth recontouring using a nano and a nanohybrid composite in combination with three- or two-step etch-and-rinse adhesives following treatment with fixed orthodontic appliances. A total of
Yingying Wen et al.
Journal of chromatography. A, 1368, 18-25 (2014-12-03)
A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was developed for the determination of non-steroidal estrogens in water samples. In this study, graphene
Mamta Bishnoi et al.
Journal of drug targeting, 22(9), 805-812 (2014-06-24)
Abstract Background: In intra-articular drug delivery, there are number of shortcomings such as lymphatic drainage from the synovial cavity, frequent dosing, adverse side effects and patient discomfort in the management of osteoarthritis (OA). This research work reports the development and
Katarina Hostanska et al.
The Journal of pharmacy and pharmacology, 66(11), 1606-1614 (2014-09-02)
Extracts of the tubers of Harpagophytum procumbens (devil's claw, DC) inhibit different proinflammatory mediators important in the pathophysiology of osteoarthritis. Many plant-derived preparations interfere with cytochrome P450 liver enzymes, which influence their different biological activities. Therefore, the present study was
Ulrich Koenig et al.
Autophagy, 11(2), 298-313 (2014-12-09)
The epithelial derived Harderian gland consists of 2 types of secretory cells. The more numerous type A cells are responsible for the secretion of lipid droplets, while type B cells produce dark granules of multilamellar bodies. The process of autophagy
Andrii Anatoliyovych Gryshchenko et al.
Journal of enzyme inhibition and medicinal chemistry, 30(1), 126-132 (2014-06-19)
New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1-sulfonamide inhibited FGFR1 with IC50 of 2 µM. In our
Arvind Thakkar et al.
International journal of oncology, 46(4), 1827-1834 (2015-02-06)
The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were
Martin Fischnaller et al.
Food chemistry, 194, 149-155 (2015-10-17)
A simple solid-phase extraction method for the enrichment of 5 bisphenol derivatives using hexagonal boron nitride (BN) was developed. BN was applied to concentrate bisphenol derivatives in spiked water samples and the compounds were analyzed using HPLC coupled to fluorescence
Maria Addolorata Saracino et al.
Journal of pharmaceutical and biomedical analysis, 104, 122-129 (2014-12-17)
A new microextraction by packed sorbent (MEPS) procedure coupled to a high-performance liquid chromatographic method has been developed for quantitation of catecholamines (i.e. norepinephrine, epinephrine and dopamine) in innovative biological samples, namely dried plasma and urine spots. Analyses were carried
Eagappanath Thiruppathi et al.
Langmuir : the ACS journal of surfaces and colloids, 30(21), 6237-6249 (2014-05-17)
Antiproliferative drugs such as paclitaxel and sirolimus are delivered from stents to inhibit the growth of smooth muscle cells (SMCs) for preventing neointimal hyperplasia. However, these drugs delay the growth of endothelial cells (ECs) as well and cause late stent
Catherine Gurley et al.
PPAR research, 2008, 453120-453120 (2008-06-28)
Microglia and astrocytes express numerous members of the Toll-like receptor (TLR) family that are pivotal for recognizing conserved microbial motifs expressed by a wide array of pathogens. Despite the critical role for TLRs in pathogen recognition, when dysregulated these pathways
Knut Fredrik Seip et al.
Journal of chromatography. A, 1347, 1-7 (2014-05-06)
Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical
Iwona Kowalska et al.
Journal of agricultural and food chemistry, 62(46), 11200-11208 (2014-10-31)
Fourteen phenolic compounds (flavonoids and phenolic acids) were isolated and 19 were identified in the aerial parts of Triticum aestivum L. The structures of these compounds were established on the basis of the data obtained by electrospray ionization-mass spectrometry (ESI-MS)
Li Yan Chan et al.
The Journal of organic chemistry, 78(17), 8826-8832 (2013-08-07)
A simple and efficient method is developed for Pd-catalyzed ortho-acetoxylation using organophosphates, namely, benzylic phosphonic and aryl phosphoric monoacids, as the directing group.
Laura Kervezee et al.
The AAPS journal, 16(5), 1029-1037 (2014-06-12)
Nearly all bodily processes exhibit circadian rhythmicity. As a consequence, the pharmacokinetic and pharmacodynamic properties of a drug may also vary with time of day. The objective of this study was to investigate diurnal variation in processes that regulate drug
Shashwati U Atwe et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 45-52 (2014-08-26)
Oral vaccination can offer a painless and convenient method of vaccination. Furthermore, in addition to systemic immunity it has potential to stimulate mucosal immunity through antigen-processing by the gut-associated lymphoid tissues. In this study we propose the concept that pollen
I Yavuz et al.
European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry, 14(1), 42-46 (2013-04-20)
This was to investigate if dental restorations on human, dog and bovine primary teeth are equitable for microleakage analysis, and the respective marginal adaptation deficiency in in vitro conditions. In order to determine the level of microleakage in Class V
Toshihiro Takashima et al.
Journal of photochemistry and photobiology. B, Biology, 152(Pt A), 139-145 (2015-02-05)
One challenge in artificial photosynthetic systems is the development of active oxygen evolution catalysts composed of abundant elements. The oxygen evolution activities of manganese pyrophosphate compounds were examined in electrochemical and photochemical experiments. Electrocatalysis using calcium-manganese pyrophosphate exhibited good catalytic
Joanna Witos et al.
The Analyst, 140(9), 3175-3182 (2015-03-10)
In this work, a method to study and analyze the interaction data in free solution by exploiting partial filling affinity capillary electrophoresis (PF-ACE) followed by adsorption energy distribution calculations (AED) prior model fit to adsorption isotherms will be demonstrated. PF-ACE-AED
Bryan A Wilson et al.
American journal of physiology. Renal physiology, 308(6), F594-F601 (2015-01-09)
Angiotensin 1-7 [ANG-(1-7)] is expressed within the kidney and exhibits renoprotective actions that antagonize the inflammatory, fibrotic, and pro-oxidant effects of ANG II. We previously identified an peptidase that preferentially metabolized ANG-(1-7) to ANG-(1-4) in the brain medulla and cerebrospinal
N A Bul'enkov et al.
Biofizika, 58(1), 8-26 (2013-05-09)
The system-forming role of the surface layer of water in the process of formation of ultrathin layers from the epoxide oligomer and triethylenetetramine or phosphotungstic acid on the surface of the aqueous phase is shown. Previously, this process was studied
Chen Shi et al.
International journal of pharmaceutics, 479(1), 41-51 (2014-12-17)
The study aims at designing a nanoparticle-based delivery system to improve the efficacy of the natural compound tetrandrine against lung cancer. Nanoparticles from poly(lactic-co-glycolic acid) (PLGA) were prepared by the emulsion solvent diffusion method and characterized for their physicochemical properties
Melissa Aline da Silva et al.
The journal of contemporary dental practice, 14(1), 9-13 (2013-04-13)
This study evaluates bond strength between dentin and composite using adhesives with different solvents to dry and wet dentin. Ninety bovine incisors were used; the vestibular surfaces were worn by the exposure of an area with a diameter of 4
Sonika Batra et al.
Biomedical chromatography : BMC, 28(6), 815-825 (2014-05-28)
Enantiomeric separation of racemic mexiletine and fluoxetine was achieved using three chiral derivatizing reagents (CDRs) based on (S)-naproxen. Diastereomers were synthesized by reaction of mexiletine or fluoxetine with the CDRs and were separated on a C18 column under reversed-phase conditions
Jannet Kamoun et al.
Biochimica et biophysica acta, 1851(2), 129-140 (2014-12-03)
Yarrowia lipolytica is a lipolytic yeast possessing 16 paralog genes coding for lipases. Little information on these lipases has been obtained and only the major secreted lipase, namely YLLIP2, had been biochemically and structurally characterized. Another secreted lipase, YLLIP8, was
Arminja N Kettenbach et al.
Journal of proteomics, 114, 48-60 (2014-12-03)
The study of cellular signaling remains a significant challenge for translational and clinical research. In particular, robust and accurate methods for quantitative phosphoproteomics in tissues and tumors represent significant hurdles for such efforts. In the present work, we design, implement
Chong-hao Bi et al.
Bioresource technology, 185, 185-193 (2015-03-17)
A novel process was developed for converting scum, a waste material from wastewater treatment facilities, to biodiesel. Scum is an oily waste that was skimmed from the surface of primary and secondary settling tanks in wastewater treatment plants. Currently scum
Izabela Ferreira Gontijo de Amorim et al.
PloS one, 6(11), e27679-e27679 (2011-12-06)
The aim of the present study was to investigate TLR2 expression in peripheral blood monocytes from dogs naturally infected with Leishmania (Leishmania) infantum to determine whether it correlates with CD11b/CD18 (CR3) expression, and to evaluate the potential of dogs as
R Kanďár et al.
Andrologia, 46(10), 1079-1088 (2013-10-16)
A method is described here for the determination of total glutathione (TGSH) and glutathione disulphide (GSSG) in the seminal plasma of the male partners of couples requesting a fertility evaluation. A suitable sample preparation procedure prior to high-performance liquid chromatography
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