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Rita Paro et al.
Toxicology and applied pharmacology, 260(2), 155-161 (2012-03-01)
The ethylene-bis-dithiocarbamate mancozeb is a widely used fungicide with low reported toxicity in mammals. In mice, mancozeb induces embryo apoptosis, affects oocyte meiotic spindle morphology and impairs fertilization rate even when used at very low concentrations. We evaluated the toxic
Sandra Cecconi et al.
Current pharmaceutical design, 13(29), 2989-3004 (2007-11-06)
Many human-made chemicals are called endocrine disruptors (EDs) because they have the potential to disrupt endocrine functions in exposed organisms. Many EDs can disrupt hormonal homeostasis by interfering with hormone receptor recognition, binding and activation, while others act by still
A Harrison Brody et al.
Neurotoxicology, 34, 74-81 (2012-10-30)
Manganese-containing fungicides like Mancozeb have been associated with neurodegenerative conditions like Parkinson's disease. We examined the behavioral damage and differential neuronal vulnerability resulting from Mancozeb exposure using Caenorhabditis elegans, an important mid-trophic level soil organism that is also a powerful
Pernille Rosenskjold Jacobsen et al.
Reproductive toxicology (Elmsford, N.Y.), 34(2), 237-250 (2012-06-09)
There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz
Shilpa Tyagi et al.
Omics : a journal of integrative biology, 15(3), 155-167 (2011-03-08)
Mancozeb, ethylene(bis)dithiocarbamate fungicides, has been well documented in the literature as a multipotent carcinogen, but the underlying mechanism remains unrevealed. Thus, mancozeb has been selected in this study with the objective to decipher the molecular mechanism that culminates in carcinogenesis.
Soudamini Mohapatra et al.
Bulletin of environmental contamination and toxicology, 88(4), 507-510 (2012-02-22)
Residue dynamics of fenamidone and mancozeb on gherkin was evaluated at two different agro climatic zones i.e. at Bangalore (Zone-1) and Dharwad (Zone-2) in the state of Karnataka, India. Two treatments of the combination formulation (fenamidone 10% + mancozeb 50%) were given
Lisa Hoffman et al.
Environmental toxicology and pharmacology, 34(2), 556-573 (2012-07-25)
The effects of the fungicides Maneb, Mancozeb, and Zineb were investigated in transformed colon cells, HT-29, Caco2 and non-transformed cells, CCD-18Co. Significant decreases in viability were observed with Maneb and Mancozeb in HT-29 and CCD-18Co (80-260μM), and Caco2 cells (40-180μM).
M Srinivasulu et al.
Environmental geochemistry and health, 34(3), 365-374 (2011-07-21)
The effect of selected pesticides, monocrotophos, chlorpyrifos alone and in combination with mancozeb and carbendazim, respectively, was tested on nitrification and phosphatase activity in two groundnut (Arachis hypogeae L.) soils. The oxidation of ammonical nitrogen was significantly enhanced under the
Emil Rekanović et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 47(5), 403-409 (2012-03-20)
A study of the in vitro sensitivity of 12 isolates of Phytophthora infestans to metalaxyl, azoxystrobin, dimethomorph, cymoxanil, zoxamide and mancozeb, was conducted. The isolates derived from infected potato leaves collected at eight different localities in Serbia during 2005-2007. The
Ping Li et al.
Toxicology letters, 219(3), 211-217 (2013-04-02)
Mancozeb (manganese/zinc ethylene bis-dithiocarbamate) is an organometallic fungicide that has been associated with human neurotoxicity and neurodegeneration. In a high-throughput screen for modulators of KCNQ2 channel, a fundamental player modulating neuronal excitability, Mancozeb, was found to significantly potentiate KCNQ2 activity.
Rekek Negga et al.
Neurotoxicity research, 21(3), 281-290 (2011-09-17)
Previous studies demonstrate a positive correlation between pesticide usage and Parkinson's disease (PD), which preferentially targets dopaminergic (DAergic) neurons. In order to examine the potential relationship between two common pesticides and specific neurodegeneration, we chronically (24 h) or acutely (30 min) exposed
P T Monteiro et al.
IET systems biology, 5(5), 308-316 (2011-10-21)
Qualitative models allow understanding the relation between the structure and the dynamics of gene regulatory networks. The dynamical properties of these models can be automatically analysed by means of formal verification methods, like model checking. This facilitates the model-validation process
Rekek Negga et al.
Neurotoxicology, 32(3), 331-341 (2011-03-08)
Epidemiological evidence suggests positive correlations between pesticide usage and the incidence of Parkinson's disease (PD). To further explore this relationship, we used wild type (N2) Caenorhabditis elegans (C. elegans) to test the following hypothesis: Exposure to a glyphosate-containing herbicide (TD)
Ritu Rani et al.
Bulletin of environmental contamination and toxicology, 90(2), 248-251 (2012-12-18)
Dissipation of mancozeb and metalaxyl in tomato was estimated following four applications of a combination formulation Ridomil MZ (mancozeb 64% + metalaxyl 8%) at 0.25 and 0.50% at 10 days interval by carbon disulphide evolution method and gas liquid chromatography
E Casalone et al.
Folia microbiologica, 55(6), 593-597 (2011-01-22)
Saccharomyces cerevisiae as model system was used to evaluate the occurrence of resistant mutants and adaptation mechanism to mancozeb (MZ), a widespread fungicide of the dithiocarbamate class with a broad spectrum of action and multiple cell targets. We were unable
Shu Qin et al.
Se pu = Chinese journal of chromatography, 28(12), 1162-1167 (2011-03-29)
A gas chromatographic method with flame photometric detection (FPD (sulfur filter)) for analyzing the residues of 4 dithiocarbamates in 22 matrices in a heated closed vial has been established. The dithiocarbamate residues were decomposed to carbon disulfide (CS2) by SnCl2-HCl
Ana Gonzálvez et al.
Analytica chimica acta, 688(2), 191-196 (2011-02-22)
A methodology based on the vapour phase (VP) generation of carbon disulphide from non-volatile dithiocarbamate compounds has been developed for determination of pesticide residues in foodstuff at low ppm levels. The method involves a selective reaction combined with liquid phase
Olga I Kubrak et al.
Ecotoxicology and environmental safety, 85, 37-43 (2012-09-12)
Intensive use of pesticides, particularly dithiocarbamates, in agriculture often leads to contamination of freshwater ecosystems. To our knowledge, the mechanisms of toxicity to fish by the carbamate fungicide Tattoo that contains mancozeb [ethylenebis(dithiocarbamate)] have not been studied. The present study
Maria K Swarcewicz et al.
Environmental monitoring and assessment, 184(5), 3077-3084 (2011-06-30)
Most agronomic situations involve a sequence of herbicide, fungicide, and insecticide application. On the other hand, use of pesticidal combinations has become a standard practice in the production of many agricultural crops. One of the most important processes influencing the
Glenda García-Santos et al.
Chemosphere, 84(5), 651-656 (2011-04-15)
Earthworm avoidance behaviour test is an important screening tool in soil eco-toxicology. This test has been developed and validated under North American and European conditions. However, little research has been performed on the avoidance test in the tropics. This work
Dulce Calçada et al.
Journal of bioinformatics and computational biology, 9(5), 613-630 (2011-10-07)
In this study we address the problem of finding a quantitative mathematical model for the genetic network regulating the stress response of the yeast Saccharomyces cerevisiae to the agricultural fungicide mancozeb. An S-system formalism was used to model the interactions
Amit Kumar Srivastava et al.
Life sciences, 90(21-22), 815-824 (2012-02-01)
Mancozeb is a dithiocarbamate fungicide known to be genotoxic and induces tumors in rodents at various sites. There is no report in the literature about its genotoxicity in humans. Here, we investigated the association between mancozeb exposure and induction of
A Alam Wani et al.
Pakistan journal of biological sciences : PJBS, 15(1), 44-48 (2012-04-26)
The persistence of fungicides on two commercial cultivars of potato was determined under field conditions at Punjab Agricultural University, Ludhiana, Punjab. Initial deposits of mancozeb on potato leaves were found to be 26.9 and 38.7 mg kg(-1), following application of
Julie Pariseau et al.
Ecotoxicology (London, England), 20(8), 1765-1772 (2011-06-21)
The aim of this study is to investigate the effects of the pesticides/polycyclic aromatic hydrocarbon mixture on aryl hydrocarbon receptor (AhR), p53 and ubiquitin mRNA level in haemocytes of Mya arenaria exposed to a mixture of chlorothalonil, mancozeb and benzo[a]pyrene
Marta Axelstad et al.
Toxicological sciences : an official journal of the Society of Toxicology, 120(2), 439-446 (2011-01-27)
The widely used fungicide mancozeb has been shown to cause hypothyroxinemia and other adverse effects on the thyroid hormone system in adult experimental animals. In humans, hypothyroxinemia early in pregnancy is associated with adverse effects on the developing nervous system
Chiranjit Kundu et al.
Bulletin of environmental contamination and toxicology, 89(6), 1253-1257 (2012-10-12)
Benalaxyl-M [methyl N-phenylacetyl-N-2, 6-xylyl-DL-alaninate] is a newly introduced phenyl-amide fungicide whereas Mancozeb is one of the member of ethylenebisdiothiocarbamate (EBDC) fungicide. Benalaxyl-M in combination with Mancozeb effectively controls downy mildew of grapes. A two season field trial was conducted under
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