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Caroline Boudousquié et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2784-2791 (2014-08-17)
Protection against reinfection is mediated by Ag-specific memory CD8 T cells, which display stem cell-like function. Because canonical Wnt (Wingless/Int1) signals critically regulate renewal versus differentiation of adult stem cells, we evaluated Wnt signal transduction in CD8 T cells during
Leonard C Edelstein et al.
Blood, 124(23), 3450-3458 (2014-10-09)
Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation kinetics in platelets from black subjects compared with white subjects. We now show that platelets from blacks (n = 70) express 14%
Y M Patel et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 716-725 (2014-03-13)
The study of patients with bleeding problems is a powerful approach in determining the function and regulation of important proteins in human platelets. We have identified a patient with a chronic bleeding disorder expressing a homozygous P2RY(12) mutation, predicting an
Sun ErLin et al.
Molecular biology of the cell, 26(10), 1947-1956 (2015-02-27)
In mouse testes, Musashi-1 (Msi-1) was predominantly expressed in the cytoplasm and nuclei of Sertoli cells. Here we demonstrate that knockdown of Msi-1 in Sertoli cells altered the levels and distribution of blood-testis barrier (BTB)-associated proteins. Moreover, Msi-1 knockdown in
Tatyana Isayeva et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(5), 631-653 (2014-12-20)
A large body of evidence shows that p16(INK4a) overexpression predicts improved survival and increased radiosensitivity in HPV-mediated oropharyngeal squamous cell carcinomas.(OPSCC). Here we demonstrate that the presence of transcriptionally active HPV16 in oral cavity squamous cell carcinomas does not correlate
Use of fluorescein isothiocyanate-dextran to measure proton pumping in lysosomes and related organelles.
S Ohkuma
Methods in enzymology, 174, 131-154 (1989-01-01)
Han Zhou et al.
Molecular medicine reports, 11(6), 4381-4388 (2015-02-06)
Polyethylenimine (PEI) has been demonstrated to be an effective non‑viral synthetic polymer for efficient gene delivery amongst various cell types in vitro and in vivo. In the present study, 25 kDa linear PEI (L‑PEI) was used to transfer plasmid DNA (pDNA), encoding the
Darshini Kuruppu et al.
Cancer research, 74(15), 4111-4121 (2014-05-31)
Viral oncolysis, the destruction of cancer cells by replicating virus, is an experimental cancer therapy that continues to be explored. The treatment paradigm for this therapy involves successive waves of lytic replication in cancer cells. At present, monitoring viral titer
Chris R Evelyn et al.
The Journal of biological chemistry, 290(20), 12879-12898 (2015-04-01)
The Ras family small GTPases regulate multiple cellular processes, including cell growth, survival, movement, and gene expression, and are intimately involved in cancer pathogenesis. Activation of these small GTPases is catalyzed by a special class of enzymes, termed guanine nucleotide
Jong-Eun Won et al.
Biomaterials, 56, 46-57 (2015-05-03)
Biomaterial surface design with biomimetic proteins holds great promise for successful regeneration of tissues including bone. Here we report a novel proteinaceous hybrid matrix mimicking bone extracellular matrix that has multifunctional capacity to promote stem cell adhesion and osteogenesis with
Alicia Lammerts van Bueren et al.
Applied and environmental microbiology, 81(12), 3973-3983 (2015-04-05)
Probiotic microorganisms are ingested as food or supplements and impart positive health benefits to consumers. Previous studies have indicated that probiotics transiently reside in the gastrointestinal tract and, in addition to modulating commensal species diversity, increase the expression of genes
S K Rao et al.
Journal of cataract and refractive surgery, 27(3), 432-436 (2001-03-20)
To evaluate the occurrence of cystoid macular edema (CME) after lens extraction, anterior vitrectomy, and intraocular lens implantation (IOL) in children using angioscopy after administration of oral fluorescein. Centers in Tamil Nadu, India, and Hong Kong, China. This study comprised
Young-Sam Cho et al.
Molecular medicine reports, 12(2), 1796-1802 (2015-04-22)
Ulinastatin is a urinary trypsin inhibitor, originally extracted and purified from human urine. Ulinastatin has cytoprotective effects against ischemic injury in several organs. In the present study, the neuroprotective effects of ulinastatin following ischemic cerebral injury in the hippocampus of
T L Cameron et al.
Osteoarthritis and cartilage, 23(4), 661-670 (2015-01-21)
To investigate the in vivo role of the IRE1/XBP1 unfolded protein response (UPR) signaling pathway in cartilage. Xbp1(flox/flox).Col2a1-Cre mice (Xbp1(CartΔEx2)), in which XBP1 activity is ablated specifically from cartilage, were analyzed histomorphometrically by Alizarin red/Alcian blue skeletal preparations and X-rays
Mohammad Raies Ul Haq et al.
European journal of nutrition, 53(4), 1039-1049 (2013-10-30)
Recently, apprehension has been raised regarding "A1/A2 hypothesis" suggesting relationship between consumption of A1 "like" variants of cow β-casein and various physiological disorders. The information available is based on either the human epidemiological data of milk consumption or in vitro
Branka Šošić-Jurjević et al.
Toxicology and applied pharmacology, 278(2), 124-134 (2014-05-06)
We previously reported that genistein (G) and daidzein (D) administered subcutaneously (10mg/kg) induce changes in the angio-follicular units of the thyroid gland, reduce concentration of total thyroid hormones (TH) and increase thyrotropin (TSH) in serum of orchidectomized middle-aged (16-month-old) rats.
J Gosálvez et al.
Andrologia, 46(6), 602-609 (2013-05-29)
Assessment of human sperm DNA fragmentation by the sperm chromatin dispersion (SCD) test is based on the detection of haloes of spreading DNA loops after sequential DNA denaturing and protamine removal. After the SCD test, sperm without DNA fragmentation show
Chen Wei et al.
Molecular biology of the cell, 26(6), 1044-1057 (2015-01-16)
General control nonderepressible kinase 2 (GCN2) is a promising target for cancer therapy. However, the role of GCN2 in cancer cell survival or death is elusive; further, small molecules targeting GCN2 signaling are not available. By using a GCN2 level-based
S Syama et al.
Toxicology mechanisms and methods, 24(9), 644-653 (2014-08-21)
Engineered nanoparticles are developed for various applications in industrial, electrical, agricultural, pharmaceutical and medical fields due to their unique properties. Nanoparticles such as TiO(2) and ZnO are widely used in cosmetics for UV protection. The toxicological investigations of ZnO NPs
Pablo J Giraudi et al.
Experimental and molecular pathology, 98(1), 85-92 (2014-12-24)
Non-alcoholic fatty liver disease is characterized by an initial accumulation of triglycerides that can progress to non-alcoholic steatohepatitis, which can ultimately evolve to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells play a key role in liver fibrogenesis by an increased
Khushwant S Bhullar et al.
Food chemistry, 168, 595-605 (2014-08-31)
Partridgeberry (Vaccinium vitis-idaea) is a polyphenol-rich berry of the Ericaceous family, grown in Newfoundland and Labrador province of Canada. The aims of this study were to identify extraction solvents for the maximum recovery of polyphenols, to establish fractionation technique for
Howard C Masuoka et al.
Digestive diseases and sciences, 60(12), 3642-3646 (2015-07-22)
Hepatocyte apoptosis or necrosis from accumulation of bile salts may play an important role in the disease progression of primary sclerosing cholangitis (PSC). The aim of the current study was to measure serum markers of hepatocyte apoptosis (cytokeratin-18 fragments--K18) and
Masateru Hiyoshi et al.
Retrovirology, 12, 73-73 (2015-08-21)
Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, there are no therapies to prevent ATL development in high-risk asymptomatic carriers. To develop a therapy targeting HTLV-1-infected cells that are known to express
Shou-Ping Shih et al.
Marine drugs, 13(5), 3132-3153 (2015-05-27)
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC50 of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively. It exhibited the most potent activity against
Ofelia Maniti et al.
Journal of liposome research, 25(2), 122-130 (2014-09-16)
Conventional liposomes have a short life-time in blood, unless they are protected by a polymer envelope, most often polyethylene glycol. However, these stabilizing polymers frequently interfere with cellular uptake, impede liposome-membrane fusion and inhibit escape of liposome content from endosomes.
Agnieszka Krupa et al.
American journal of physiology. Lung cellular and molecular physiology, 307(6), L435-L448 (2014-08-03)
Previous observations made by our laboratory indicate that Bruton's tyrosine kinase (Btk) may play an important role in the pathophysiology of local inflammation in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). We have shown that there is cross talk
Di Gao et al.
ACS applied materials & interfaces, 7(24), 13524-13537 (2015-05-29)
Ultrasound as an external stimulus for enhanced gene transfection represents a safe, noninvasive, cost-effective delivery strategy for gene therapy. Herein, we have developed an ultrasound-triggered phase-transition cationic nanodroplet based on a novel perfluorinated amphiphilic poly(amino acid), which could simultaneously load
Michael S Dittmar et al.
PloS one, 10(6), e0130408-e0130408 (2015-06-20)
The effects of anesthetics on the injured brain continue to be the subject of controversial discussion. Since isoflurane has recently been shown to induce apoptosis of cerebral endothelial cells, this study compared different anesthetic compounds regarding their potential to induce
Lan Zhang et al.
PloS one, 9(5), e97824-e97824 (2014-05-20)
Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced obesity mice, a model of
Stefanie Steiner et al.
Archivum immunologiae et therapiae experimentalis, 63(1), 53-63 (2014-08-27)
Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel diseases (IBD), which are defined as relapsing inflammations of the gastrointestinal tract. Cyclosporine A (CsA) is a potential rescue treatment to avoid colectomy in severe
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