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499145

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Molecular mass spectrometry in metallodrug development: a case of mapping transferrin-mediated transformations for a ruthenium(III) anticancer drug.

Maciej Jarosz et al.

Analytica chimica acta, 851, 72-77 (2014-12-03)

Electrospray ionization mass spectrometry (ESI-MS) techniques have been used to characterize the speciation of a Ru(III) anticancer drug, indazolium trans-[tetrachloridobis(1H-indazole) ruthenate(III)], upon its binding to transferrin and the impact of cellular reducing components on drug-transferrin adducts. Using time-of-flight ESI-MS, the

Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography.

Panfeng Yu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)

This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites

Star-shaped tetraspermine enhances cellular uptake and cytotoxicity of T-oligo in prostate cancer cells.

Vidula Kolhatkar et al.

Pharmaceutical research, 32(1), 196-210 (2014-08-06)

An oligonucleotide termed 'T-oligo' having sequence homology with telomere overhang has shown cytotoxicity in multiple cancers. We have demonstrated that T-oligo can induce apoptosis in androgen independent prostate cancer cell line DU-145. In this report, we evaluate the use of

Development of antileishmanial lipid nanocomplexes.

T T H Pham et al.

Biochimie, 107 Pt A, 143-153 (2014-06-22)

Visceral leishmaniasis is a life-threatening disease that affects nearly a million people every year. The emergence of Leishmania strains resistant to existing drugs complicates its treatment. The purpose of this study was to develop a new lipid formulation based on

Hydrogen-deuterium exchange in imidazole as a tool for studying histidine phosphorylation.

Małgorzata Cebo et al.

Analytical and bioanalytical chemistry, 406(30), 8013-8020 (2014-10-31)

Isotope exchange at the histidine C2 atom of imidazole in D2O solution is well known to occur at a significantly slower rate than the exchange of amide protons. Analysis of the kinetics of this isotope-exchange reaction is proposed herein as

Detection, identification, and quantification of hydroxylated bis(2-ethylhexyl)-tetrabromophthalate isomers in house dust.

Hui Peng et al.

Environmental science & technology, 49(5), 2999-3006 (2015-01-27)

Ultra-High Resolution LC/mass spectrometry (LC-UHRMS; Thermo Fisher Q-Exactive) was used to identify two novel isomers of hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) which were unexpectedly observed in a commercial standard of TBPH. By combining ultra-high resolution (UHR) mass spectra (MS(1)), mass errors to

A rapid and sensitive assay for determination of doxycycline using thioglycolic acid-capped cadmium telluride quantum dots.

Javad Tashkhourian et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 152, 119-125 (2015-07-24)

A rapid, simple and inexpensive spectrofluorimetric sensor for determination of doxycycline based on its interaction with thioglycolic acid-capped cadmium telluride quantum dots (TGA/CdTe QDs) has been developed. Under the optimum experimental conditions, the sensor exhibited a fast response time of

Characterization of genome-reduced fission yeast strains.

Mayumi Sasaki et al.

Nucleic acids research, 41(10), 5382-5399 (2013-04-09)

The Schizosaccharomyces pombe genome is one of the smallest among the free-living eukaryotes. We further reduced the S. pombe gene number by large-scale gene deletion to identify a minimal gene set required for growth under laboratory conditions. The genome-reduced strain

Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.

Gul N Shah et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7423-7428 (2013-04-17)

Prior studies with carbonic anhydrase (CA) inhibitors implicated mitochondrial CA in ureagenesis and gluconeogenesis. Subsequent studies identified two mitochondrial CAs. To distinguish the contribution of each enzyme, we studied the effects of targeted disruption of the murine CA genes, called

Clinical and biochemical consequences of soybean meal intoxication in cattle.

D Raboisson et al.

The Veterinary record, 172(20), 529-529 (2013-04-23)

Determining the composition of ammonia/water mixtures using short-wave near-infrared spectroscopy.

M Isabel Barba et al.

Talanta, 147, 111-116 (2015-11-26)

This paper proposes a methodology based on short-wave near-infrared spectroscopy to determine the ammonia content of ammonia/water mixtures with ammonia mass fraction in the range 0.35-0.65. Establishing this methodology meant modeling the relationship between the pressure bar (15-25)bar, temperature (20-50)°C

Measurement and interpretation of plasma ammonia.

H J Lee et al.

British journal of hospital medicine (London, England : 2005), 75(3), C40-C43 (2014-03-14)

Reduced graphene oxide nanosheets coated with an anti-angiogenic anticancer low-molecular-weight heparin derivative for delivery of anticancer drugs.

Gayong Shim et al.

Journal of controlled release : official journal of the Controlled Release Society, 189, 80-89 (2014-06-29)

Here, we report reduced graphene oxide (rGO) nanosheets coated with an anti-angiogenic anticancer taurocholate derivative of low-molecular-weight heparin (LHT7) as a tumor-targeting nanodelivery platform for anticancer drugs. Surface coating of LHT7 onto rGO was confirmed using fluorescein isothiocyanate-labeled LHT7, monitored

Graphene oxide-based microspheres for the dispersive solid-phase extraction of non-steroidal estrogens from water samples.

Yingying Wen et al.

Journal of chromatography. A, 1368, 18-25 (2014-12-03)

A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was developed for the determination of non-steroidal estrogens in water samples. In this study, graphene

Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market.

Susana Sadler Simões et al.

Forensic science international, 243, 117-125 (2014-08-16)

An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids and/or their metabolites in urine samples (1mL). Prior to extraction the samples were subjected

Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD.

Lina Zuluaga-Idárraga et al.

Journal of pharmaceutical and biomedical analysis, 95, 200-206 (2014-04-01)

One of the most important aspects regarding the therapeutic efficacy of antimalarials is its quantification in biologic fluids. The detection and measurement of antimalarial drug levels is important for demonstrating (1) adequate absorption of the drug being given, (2) compliance

Postsynthetic conjugation of RNA to carboxylate and dicarboxylate molecules.

Yossi Shemesh et al.

Nucleosides, nucleotides & nucleic acids, 34(11), 753-762 (2015-10-01)

Carboxylates and dicarboxylates are important phosphate mimics. Herein, we present a simple synthetic route for the preparation of RNA carboxylate/dicarboxylate conjugates, starting from suitably protected NH2- and COOH-containing molecules that are coupled to the RNA on the solid support. The

Influence of nitrogen sources on growth and fermentation performance of different wine yeast species during alcoholic fermentation.

Varongsiri Kemsawasd et al.

Applied microbiology and biotechnology, 99(23), 10191-10207 (2015-08-11)

In this study, the influence of twenty different single (i.e. 19 amino acids and ammonium sulphate) and two multiple nitrogen sources (N-sources) on growth and fermentation (i.e. glucose consumption and ethanol production) performance of Saccharomyces cerevisiae and of four wine-related

Renal ammonia metabolism and transport.

I David Weiner et al.

Comprehensive Physiology, 3(1), 201-220 (2013-05-31)

Renal ammonia metabolism and transport mediates a central role in acid-base homeostasis. In contrast to most renal solutes, the majority of renal ammonia excretion derives from intrarenal production, not from glomerular filtration. Renal ammoniagenesis predominantly results from glutamine metabolism, which

Comparison of UHPLC and HPLC in benzodiazepines analysis of postmortem samples: a case-control study.

Behnam Behnoush et al.

Medicine, 94(14), e640-e640 (2015-04-11)

The aim of this study was to compare system efficiency and analysis duration regarding the solvent consumption and system maintenance in high-pressure liquid chromatography (HPLC) and ultra high-pressure liquid chromatography (UHPLC). In a case-control study, standard solutions of 7 benzodiazepines

N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.

Dana Hocková et al.

Organic & biomolecular chemistry, 13(15), 4449-4458 (2015-03-15)

Protected N-branched nucleoside phosphonates containing adenine and thymine bases were prepared as the monomers for the introduction of aza-acyclic nucleotide units into modified oligonucleotides. The phosphotriester and phosphoramidite methods were used for the incorporation of modified and natural units, respectively.

An analytical quality by design (aQbD) approach for a L-asparaginase activity method.

Han Yao et al.

Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)

L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance

Graphene-derivatized silica as an efficient solid-phase extraction sorbent for pre-concentration of fluoroquinolones from water followed by liquid-chromatography fluorescence detection.

Andrea Speltini et al.

Journal of chromatography. A, 1379, 9-15 (2015-01-07)

This work presents a novel analytical method based on graphene for the determination of five widely used fluoroquinolones (FQs) in aqueous matrices. The procedure entails solid-phase extraction (SPE) on graphene-derivatized silica (200mg), followed by liquid chromatography with fluorescence detection. Monolayer

Dual core quantum dots for highly quantitative ratiometric detection of trypsin activity in cystic fibrosis patients.

Iván Castelló Serrano et al.

Nanoscale, 6(22), 13623-13629 (2014-10-03)

We present herein two colour encoded silica nanospheres (2nanoSi) for the fluorescence quantitative ratiometric determination of trypsin in humans. Current detection methods for cystic fibrosis diagnosis are slow, costly and suffer from false positives. The 2nanoSi proved to be a

Determination of selected water-soluble vitamins using hydrophilic chromatography: a comparison of photodiode array, fluorescence, and coulometric detection, and validation in a breakfast cereal matrix.

Swen Langer et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 73-81 (2014-05-06)

Water-soluble vitamins are an important class of compounds that require quantification from food sources to monitor nutritional value. In this study we have analysed six water-soluble B vitamins ([thiamine (B1), riboflavin (B2), nicotinic acid (B3, NAc), nicotinamide (B3, NAm), pyridoxal

A smart upconversion-based mesoporous silica nanotheranostic system for synergetic chemo-/radio-/photodynamic therapy and simultaneous MR/UCL imaging.

Wenpei Fan et al.

Biomaterials, 35(32), 8992-9002 (2014-08-12)

To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may

Endogenous expression pattern of resolvin D1 in a rat model of self-resolution of lipopolysaccharide-induced acute respiratory distress syndrome and inflammation.

Wei Sun et al.

International immunopharmacology, 23(1), 247-253 (2014-09-15)

Resolvin D1 (RvD1), an endogenous lipid mediator derived from docosahexaenoic acid, has been reported to promote a biphasic activity in anti-inflammatory response and regulate inflammatory resolution. The present study aimed to determine the endogenous expression pattern of RvD1 in a

Impact of Precursors Creatine, Creatinine, and Glucose on the Formation of Heterocyclic Aromatic Amines in Grilled Patties of Various Animal Species.

Monika Gibis et al.

Journal of food science, 80(11), C2430-C2439 (2015-10-08)

The impact of precursors such as creatine, creatinine, and glucose on the formation of mutagenic/carcinogenic heterocyclic amines (HAs) were studied in patties of 9 different animal species equally heat treated with a double-plate contact grill. All grilled patties of the

Excretory nitrogen metabolism and defence against ammonia toxicity in air-breathing fishes.

S F Chew et al.

Journal of fish biology, 84(3), 603-638 (2014-01-21)

With the development of air-breathing capabilities, some fishes can emerge from water, make excursions onto land or even burrow into mud during droughts. Air-breathing fishes have modified gill morphology and morphometry and accessory breathing organs, which would tend to reduce

Anaerobic degradation of carbon capture reclaimer MEA waste.

S Wang et al.

Water science and technology : a journal of the International Association on Water Pollution Research, 67(11), 2549-2559 (2013-06-12)

The anaerobic biodegradation of reclaimer MEA (monoethanolamine) waste (MEAw) with easily degradable co-substrates was investigated in a laboratory-scale bioreactor at room temperature during a 160 d experimental run. The reactor that was constructed with three phases to facilitate attached biofilm

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