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A simple salting out procedure for extracting DNA from human nucleated cells.
S A Miller et al.
Nucleic acids research, 16(3), 1215-1215 (1988-02-11)
Christophe Varin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(27), 9900-9911 (2015-07-15)
Sleep-active neurons located in the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS). However, the cellular and molecular mechanisms responsible for their activation at sleep onset remain poorly understood. Here, we
Izrail Tsals et al.
Vaccine, 33(37), 4705-4711 (2015-05-13)
Although the number of vaccines and diagnostic tests currently delivered intradermally is limited, this route of administration offers potential advantages due to the high concentration of antigen-presenting cells in the skin. One factor which may in part be limiting development
Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII.
Suzanne M Underhill et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5260-5270 (2015-04-04)
The gene for EAAT2, the major astrocytic glutamate transporter, generates two carrier isoforms (EAAT2a and EAAT2b) that vary at their C termini as a consequence of alternative RNA splicing. The EAAT2b cytoplasmic C terminus contains a postsynaptic density-95/Discs large/zona occludens-1
Valentina Fodale et al.
PloS one, 9(12), e112262-e112262 (2014-12-03)
In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregate. Recent data demonstrate that
Kentu Lassiter et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(3), R173-R187 (2014-12-17)
Orexin A and B, orexigenic peptides produced primarily by the lateral hypothalamus that signal through two G protein-coupled receptors, orexin receptors 1/2, have been implicated in the regulation of several physiological processes in mammals. In avian (nonmammalian vertebrates) species; however
Krishna Gokul et al.
Neurochemical research, 39(7), 1382-1394 (2014-05-17)
Although tomato seeds (an industrial by-product) are known to contain several bioactive compounds, studies describing their health effects are limited. Previously, we evidenced that aqueous extract of tomato seeds (TSE) markedly attenuated rotenone (ROT)-induced oxidative stress and neurotoxicity in Drosophila
Justyna McIntyre et al.
The Journal of biological chemistry, 290(45), 27332-27344 (2015-09-16)
Human DNA polymerases (pols) η and ι are Y-family DNA polymerase paralogs that facilitate translesion synthesis past damaged DNA. Both polη and polι can be monoubiquitinated in vivo. Polη has been shown to be ubiquitinated at one primary site. When
Amber L Jolly et al.
mBio, 6(2), e02533-e02533 (2015-02-26)
The opportunistic pathogen Pseudomonas aeruginosa can infect almost any site in the body but most often targets epithelial cell-lined tissues such as the airways, skin, and the cornea of the eye. A common predisposing factor is cystic fibrosis (CF), caused
Shigeo Nagashima et al.
The Journal of general virology, 95(Pt 10), 2166-2175 (2014-06-28)
Our previous studies indicated that hepatitis E virus (HEV) forms membrane-associated particles in the cytoplasm, most likely by budding into intracellular vesicles, and requires the multivesicular body (MVB) pathway to release virus particles, and the released HEV particles with a
Haihao Ma et al.
Scientific reports, 5, 18186-18186 (2015-12-15)
The cotton bollworm, Helicoverpa armigera, has developed strong resistance to many insecticides. Sterol Carrier Protein-2 (SCP-2) is an important non-specific lipid transfer protein in insects and appears to be a potential new target. In order to elucidate the structure and
Satoshi Fujita et al.
Journal of vascular surgery, 62(5), 1312-1319 (2014-05-14)
The development of spinal cord injury is believed to be related to the vulnerability of spinal motor neurons to ischemia. However, the mechanisms underlying this vulnerability have not been fully investigated. Previously, we reported that spinal motor neurons are lost
Cailing Liu et al.
Investigative ophthalmology & visual science, 55(9), 5551-5560 (2014-08-02)
To investigate the role of DJ-1 in Nrf2-regulated antioxidant defense in corneal endothelial cells (CECs) at baseline and in response to ultraviolet A (UV-A)-induced oxidative stress. DJ-1-deficient CECs were obtained by transfection of an immortalized normal human corneal endothelial cell
Anastasia Antonopoulou et al.
Journal of chemotherapy (Florence, Italy), 27(2), 80-86 (2014-02-20)
Methicillin-resistant Staphylococcus aureus (MRSA) producing Panton-Valentine leukocidin (PVL) is highly virulent. This study aimed to compare the efficacy of tigecycline versus vancomycin in experimental thigh abscess by a PVL-producing MRSA isolate. One hundred and ninety-six Wistar rats were divided into
G Mészáros et al.
Acta physiologica Hungarica, 102(2), 216-227 (2015-06-24)
Mitochondrial functions have a major impact on T-cell functionality. In this study we characterized whether mitochondrial function in the neonatal T-cells differs from that in the adult T-cells during short T-cell activation. We used flow cytometry methods to test mitochondrial
Jihwan Myung et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(29), E3920-E3929 (2015-07-02)
The mammalian suprachiasmatic nucleus (SCN) forms not only the master circadian clock but also a seasonal clock. This neural network of ∼10,000 circadian oscillators encodes season-dependent day-length changes through a largely unknown mechanism. We show that region-intrinsic changes in the
Kalyan C Tirupula et al.
PloS one, 9(7), e103520-e103520 (2014-07-30)
MAS is a G protein-coupled receptor (GPCR) implicated in multiple physiological processes. Several physiological peptide ligands such as angiotensin-(1-7), angiotensin fragments and neuropeptide FF (NPFF) are reported to act on MAS. Studies of conventional G protein signaling and receptor desensitization
Savitha Sambandamoorthy et al.
Biology open, 4(7), 885-892 (2015-05-24)
Integrin-mediated cell adhesion to the ECM regulates many physiological processes in part by controlling cell proliferation. It is well established that many normal cells require integrin-mediated adhesion to enter S phase of the cell cycle. Recent evidence indicates that integrins
Andrew C Meyer et al.
Psychopharmacology, 232(13), 2275-2285 (2015-01-09)
Previous research suggests both genetic and environmental influences on substance abuse vulnerability. The current work sought to investigate the interaction of genes and environment on the acquisition of amphetamine self-administration as well as amphetamine-stimulated dopamine (DA) release in nucleus accumbens
Mohamed Mlih et al.
Molecular and cellular biochemistry, 404(1-2), 211-220 (2015-03-12)
Osteopontin (OPN), a multifunctional glycophosphoprotein, has been reported to contribute to the development and progression of cardiac remodeling and hypertrophy. Cardiac-specific OPN knockout mice were protected against hypertrophy and fibrosis mediated by Ang II. Recently, transgenic mice expressing the active
Shogo Sasaki et al.
Journal of bioscience and bioengineering, 119(2), 200-205 (2014-07-26)
We demonstrated the synthesis of molecularly imprinted polymers (MIPs) with binding affinity toward a target protein, ribonuclease A (RNase) by atom transfer radical polymerization (ATRP) of acrylic acid, acrylamide, and N,N'-methylenebisacrylamide in the presence of RNase. The binding activity of
Immacolata Venditto et al.
Acta crystallographica. Section F, Structural biology communications, 71(Pt 6), 784-789 (2015-06-10)
A number of anaerobic microorganisms produce multi-modular, multi-enzyme complexes termed cellulosomes. These extracellular macromolecular nanomachines are designed for the efficient degradation of plant cell-wall carbohydrates to smaller sugars that are subsequently used as a source of carbon and energy. Cellulolytic
Wan Chen et al.
The Journal of steroid biochemistry and molecular biology, 152, 16-24 (2015-04-25)
Glucocorticoid-induced tendon rupture is very common in clinical practice, and the overall outcome of surgical suture repair is rather poor. The mechanism remains unclear, and effective treatments are still lacking. In the present study, we investigated the effect of dexamethasone
Tejinder Singh et al.
American journal of physiology. Renal physiology, 309(3), F189-F203 (2015-06-19)
ANG II type 1 receptor blockade (AT1R-BLK) is used extensively to slow down the progression of proteinuric kidney diseases. We hypothesized that AT1R-BLK provides podocyte protection through regulation of silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and
Casey G Langdon et al.
Oncotarget, 6(35), 37410-37425 (2015-10-21)
Targeting anti-apoptotic proteins can sensitize tumor cells to conventional chemotherapies or other targeted agents. Antagonizing the Inhibitor of Apoptosis Proteins (IAPs) with mimetics of the pro-apoptotic protein SMAC is one such approach. We used sensitization compound screening to uncover possible
Jiying Liu et al.
FEBS letters, 588(23), 4497-4503 (2014-12-03)
Smad7 has a key role in apoptosis of mammalian ovarian granulosa cells (GCs), as it antagonizes and fine-tunes transforming growth factor β (TGFβ) signaling. This study demonstrates that miR-92a regulates GC apoptosis in pig ovaries by targeting Smad7 directly. The
Sayaka Matsumura et al.
Journal of dermatological science, 78(3), 215-223 (2015-04-01)
Nerve growth factor (NGF), a neurotrophin that plays a critical role in developmental neurobiology, is released by proliferating keratinocytes and induces proliferation. The aim of this study was to investigate the role of tyrosine kinase receptor A (TrkA), a high-affinity
Xiaojun Ge et al.
Molecular medicine reports, 11(1), 333-340 (2014-10-24)
The aim of the present study was to establish, characterize and elucidate the potential mechanisms of acquired gefitinb resistance, using the A549 human lung cancer cell line. A gefitinib-resistant A549 sub-clone was established by exposure to escalating gefitinib concentrations over
Qingchun Mu et al.
Cancer biology & therapy, 16(4), 623-633 (2015-02-27)
Glioblastomas multiforme (GBM) are the most frequently occurring malignant brain cancers. Treatment for GBM consists of surgical resection and subsequent adjuvant radiation therapy and chemotherapy. Despite this, GBM patient survival is limited to 12-15 months, and researchers are continually trying to
Falk Dittrich et al.
BMC neuroscience, 15, 128-128 (2014-12-03)
In male birds, influence of the sex steroid hormone testosterone and its estrogenic metabolites on seasonal song behavior has been demonstrated for many species. In contrast, female song was only recently recognized to be widespread among songbird species, and to
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