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Sandra C Mayer et al.
Circulation research, 117(7), 622-633 (2015-07-22)
In chronic heart failure, increased adrenergic activation contributes to structural remodeling and altered gene expression. Although adrenergic signaling alters histone modifications, it is unknown, whether it also affects other epigenetic processes, including DNA methylation and its recognition. The aim of
Annalisa Conti et al.
Oncotarget, 6(13), 10994-11008 (2015-06-02)
KRAS is mutated in about 20-25% of all human cancers and especially in pancreatic, lung and colorectal tumors. Oncogenic KRAS stimulates several pro-survival pathways, but it also triggers the trans-activation of pro-apoptotic genes. In our work, we show that G13D
Masanori Someya et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 115(2), 235-239 (2015-05-06)
Late rectal bleeding is one of the severe adverse events after radiotherapy for prostate cancer. New biomarkers are needed to allow a personalized treatment. Four patients each with grade 0-1 or grade 2-3 rectal bleeding were randomly selected for miRNA
Matthew D Giangola et al.
The Journal of surgical research, 199(2), 572-579 (2015-07-18)
Renal injury caused by ischemia-reperfusion (I/R) often occurs after shock or transplantation. Growth arrest-specific protein 6 (Gas6) is a secreted protein that binds to the TAM-Tyro3, Axl, Mer-family tyrosine kinase receptors, which modulate the inflammatory response and activate cell survival
Ana C Carvalho et al.
Free radical biology & medicine, 83, 262-272 (2015-03-07)
Mild stress-induced hormesis represents a promising strategy for targeting the age-related accumulation of molecular damage and, therefore, for preventing diseases and achieving healthy aging. Fruits, vegetables, and spices contain a wide variety of hormetic phytochemicals, which may explain the beneficial
Guodong Wang et al.
Gene, 571(1), 65-70 (2015-06-28)
Insulin-like growth factor binding protein 7 (IGFBP7) binds IGFs with a low affinity, but in contrast, recognizes insulin with a high affinity. Many studies show that IGFBP7 involves several cellular processes of vertebrates and functions as a tumor suppressor gene
Qi Wu et al.
Marine drugs, 12(12), 6125-6141 (2014-12-23)
Astaxanthin (ATX) has been proven to ameliorate early brain injury (EBI) after experimental subarachnoid hemorrhage (SAH) by modulating cerebral oxidative stress. This study was performed to assess the effect of ATX on the Nrf2-ARE pathway and to explore the underlying
Xue Fu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 432-451 (2014-03-13)
Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study
Zhenhuan Guo et al.
Science signaling, 7(354), rs7-rs7 (2014-12-04)
E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extracellular cadherin domains and is regulated by an assembly of intracellular adaptors and enzymes associated
Hannah M Kaneb et al.
Human molecular genetics, 24(5), 1363-1373 (2014-10-26)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective death of motor neurons. Causative mutations in the global RNA-processing proteins TDP-43 and FUS among others, as well as their aggregation in ALS patients, have identified defects
C O Rosario et al.
Oncogene, 34(26), 3441-3451 (2014-09-02)
Polo family kinase 4 (Plk4) is required for mitotic progression, and is haploinsufficient for tumor suppression and timely hepatocyte polarization in regenerating liver. At the same time, recent evidence suggests that Plk4 expression may have a role in clinical cancer
Sara Rodrigues et al.
Drug and chemical toxicology, 38(2), 126-132 (2014-05-23)
In recent decades, scientific research about the effects of anthropogenic xenobiotics on non-target organisms has increased. Among the likely effects, some studies reported the evaluation of biochemical and morphological changes in specific tissues or organs of fishes, such as gills
Francesca Barone et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(35), 11024-11029 (2015-08-20)
The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs following tissue damage remain unclear. Using a virus-induced model of autoantibody formation in the salivary glands of adult mice, we demonstrate that IL-22 provides a mechanistic
Jennifer A Thomas et al.
Journal of molecular biology, 426(24), 4139-4154 (2014-12-03)
The overexpression of authentically folded eukaryotic membrane proteins in milligramme quantities is a fundamental prerequisite for structural studies. One of the most commonly used expression systems for the production of mammalian membrane proteins is the baculovirus expression system in insect
Alessandra Fabietti et al.
Proteomics, 13(8), 1375-1378 (2013-03-02)
This study reports the first extensive shotgun analysis of the Bartonella quintana proteome. Proteins extracted from two B. quintana strains, Oklahoma and JK31, were analyzed in triplicate analyses by a bottom-up approach consisting of tryptic digestion in SDS-containing buffer, strong
Yanwu You et al.
BMC nephrology, 16, 148-148 (2015-08-28)
Fractalkine (FKN) is involved in the occurrence and development of human lupus nephritis. It is known to be upregulated by lipopolysaccharide (LPS) as a stimulus in vivo. MRL/lpr mice have been used as an in vivo model to study lupus
Ankita Thakur et al.
Immunobiology, 220(9), 1031-1038 (2015-05-24)
Visceral leishmaniasis (VL) caused by Leishmania donovani persists as a major public health issue in tropical and subtropical areas of the world. Current treatment of this disease relies on use of drugs. It is doubtful that chemotherapy can alone eradicate
R Emani et al.
Scandinavian journal of immunology, 81(2), 102-109 (2014-11-21)
Macrophages play a crucial role in innate immune reactions, and peritoneal macrophages (PMs) guard the sterility of this compartment mainly against microbial threat from the gut. Type 1 diabetes (T1D) is an autoimmune disease in which gut microbiota and gut
Marc Swidergall et al.
Eukaryotic cell, 14(4), 359-370 (2015-02-01)
Candida albicans adapts to the human host by environmental sensing using the Msb2 signal mucin, which regulates fungal morphogenesis and resistance characteristics. Msb2 is anchored within the cytoplasmic membrane by a single transmembrane (TM) region dividing it into a large
Miaki Uzu et al.
Journal of pharmacological sciences, 128(1), 17-26 (2015-05-25)
Connexin (Cx) makes up a type of intercellular channel called gap junction (GJ). GJ plays a regulatory role in cellular physiology. The Cx expression level is often decreased in cancer cells compared to that in healthy ones, and the restoration
Kyu-Min Han et al.
Stem cells (Dayton, Ohio), 33(5), 1447-1455 (2015-02-03)
Cardio-facio-cutaneous (CFC) syndrome is a developmental disorder caused by constitutively active ERK signaling manifesting mainly from BRAF mutations. Little is known about the role of elevated ERK signaling in CFC syndrome during early development. Here, we show that both SMAD1
Ewa Augustin et al.
Acta pharmacologica Sinica, 36(3), 385-399 (2015-02-03)
FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on
Ioanna Tiniakou et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4676-4687 (2015-04-15)
Aberrant levels and function of the potent anti-inflammatory high-density lipoprotein (HDL) and accelerated atherosclerosis have been reported in patients with autoimmune inflammatory diseases. Whether HDL affects the development of an autoimmune response remains elusive. In this study, we used apolipoprotein
Matthew R Panasevich et al.
The Journal of nutrition, 145(12), 2781-2788 (2015-10-23)
Dietary fiber intake leading to short-chain fatty acid (SCFA) production could be a strategy to combat intermittent bouts of inflammation during ulcerative colitis. Our objective was to evaluate dietary potato fiber (PF) in attenuating inflammation using a dextran sodium sulfate
Uwe Richter et al.
The Journal of cell biology, 211(2), 373-389 (2015-10-28)
Mitochondrial ribosomes synthesize a subset of hydrophobic proteins required for assembly of the oxidative phosphorylation complexes. This process requires temporal and spatial coordination and regulation, so quality control of mitochondrial protein synthesis is paramount to maintain proteostasis. We show how
Chang-Nim Im et al.
Oncology reports, 34(2), 920-928 (2015-06-03)
More efficient isolation and identification of cancer stem cells (CSCs) would help in determining their fundamental roles in tumor biology. The classical tool for this purpose is anchorage-independent tumorsphere culture. We compared the effects of differently textured culture plates and
Abdelkader Selmi et al.
Cancer letters, 357(1), 412-418 (2014-12-06)
In neuroblastoma, MYCN amplification is associated with a worse prognosis and is a criterion used in the clinic to provide intensive treatments to children even with localized disease. In correlation with MYCN amplification, upregulation of TWIST1, a transcription factor playing
Yuki Nagahara et al.
Journal of neuroscience research, 93(10), 1552-1566 (2015-07-04)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons and subsequent muscular atrophy. The quality of life of patients with ALS is significantly improved by ameliorating muscular symptoms. We previously reported that glycoprotein nonmetastatic
Masashi Kamikawa et al.
Acta histochemica et cytochemica, 47(2), 35-43 (2014-09-16)
We previously demonstrated that macrophages exhibit endoplasmic reticulum fragmentation under cholesterol-rich conditions, which results in the generation of acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1)-associated late endosomes/lysosomes (ACAT1-LE). ACAT1-LE efficiently esterify free cholesterol in loco, even with abnormal egress of free
Huinan Zhao et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(3), 189-196 (2014-09-16)
1.Anhuienoside C (A-C) is the main active component of the saponin exact of "Di Wu", an oral drug for rheumatism treatment in China. In this study, we aimed to elucidate the metabolic pathways of A-C by intestinal bacteria using the
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