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Kyu-Yeon Han et al.
FEBS letters, 588(23), 4357-4363 (2014-10-05)
The vascular endothelial growth factor (VEGF)-C-induced down-regulation of VEGF receptor (VEGFR)-3 is important in lymphangiogenesis. Here, we demonstrate that VEGF-C, -D, and -C156S, but not VEGF-A, down-regulate VEGFR-3. VEGF-C stimulates VEGFR-3 tyrosyl phosphorylation and transient phosphorylation of extracellular signal-regulated kinase
Sheng-Wei Luo et al.
Ecotoxicology (London, England), 24(7-8), 1775-1787 (2015-05-10)
Vibrio alginolyticus containing the highly toxic extracellular product is one of the most serious threats to grouper survival and its minimum lethal dose is approximately 500 CFU/g fish body weight in grouper. To study the toxic effects of V. alginolyticus
Lester Carter et al.
Biophysical journal, 109(4), 793-805 (2015-08-20)
Aberrant self-assembly, induced by structural misfolding of the prion proteins, leads to a number of neurodegenerative disorders. In particular, misfolding of the mostly α-helical cellular prion protein (PrP(C)) into a β-sheet-rich disease-causing isoform (PrP(Sc)) is the key molecular event in
Remigiusz Żurawiński et al.
Organic & biomolecular chemistry, 13(25), 7000-7012 (2015-06-02)
The synthesis of two cross-conjugated prostaglandin analogues of known neurotrophic activity and their new hydroxy derivatives was accomplished starting from the diastereoisomeric (+)-camphor protected 3-[(dimethoxyphosphoryl)methyl]-4,5-dihydroxycyclopent-2-enones. The cytotoxicity of these compounds was determined against HeLa, K562, HL-60 human cancer cell lines
Valentina Fodale et al.
PloS one, 9(12), e112262-e112262 (2014-12-03)
In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregate. Recent data demonstrate that
Maria Bexten et al.
Molecular pharmaceutics, 12(1), 171-178 (2014-12-04)
The cationic, water-soluble quaternary trospium chloride (TC) is incompletely absorbed from the gut and undergoes wide distribution but does not pass the blood-brain barrier. It is secreted by the kidneys, liver, and intestine. To evaluate potential transport mechanisms for TC
Shuji Sugiura et al.
The Journal of investigative dermatology, 135(3), 776-785 (2014-10-15)
Human prolactin-induced protein (PIP) is a major protein found in exocrine fluids such as saliva and sweat. Intriguingly, PIP possesses residues (human PIP (hPIP): PIP (29-63)) that display similarity to the aspartic peptidase candidapepsin. Here, we aimed to determine the
Do-Yoon Kim et al.
Pharmaceutical biology, 53(5), 725-734 (2014-10-22)
Chrysanthemum boreale Makino (Compositae) (CBM) is a traditional medicine that has been used for the prevention or treatment of various disorders; it has various properties including antioxidation, anti-inflammation, and antitumor. The present study was designed to explore the in vitro
Robert A Gelfand et al.
The journal of sexual medicine, 12(2), 313-327 (2014-12-17)
The success of medical therapies for Peyronie's disease (PD) has not been optimal, possibly because many of them went directly to clinical application without sufficient preclinical scientific research. Previous studies revealed cellular and molecular pathways involved in the formation of
Satoshi Fujita et al.
Journal of vascular surgery, 62(5), 1312-1319 (2014-05-14)
The development of spinal cord injury is believed to be related to the vulnerability of spinal motor neurons to ischemia. However, the mechanisms underlying this vulnerability have not been fully investigated. Previously, we reported that spinal motor neurons are lost
Choong-Kun Lee et al.
American journal of cancer research, 5(1), 72-86 (2015-01-30)
We aimed to determine whether KRAS and BRAF mutant colorectal cancer (CRC) cells exhibit distinct sensitivities to the multi-target angiokinase inhibitor, TKI258 (dovitinib). We screened 10 CRC cell lines by using receptor tyrosine kinase (RTK) array to identify activated RTKs.
Isaac Dadzie et al.
Research in microbiology, 165(6), 439-446 (2014-05-27)
Bacterial cis-encoded antisense RNAs are transcribed from the opposite strand of protein coding genes, and their regulatory roles adapt cells to changing environmental conditions. By deep sequencing of the transcriptome of Salmonella enterica serovar Typhi, an antisense RNA that is
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
Hui-Mei Wu et al.
Human pathology, 45(9), 1936-1943 (2014-08-02)
Gene associated with retinoid and interferon-induced mortality 1 (GRIM-1) acts as a tumor growth suppressor via apoptosis induction. However, GRIM-1 expression in human non-small cell lung cancer (NSCLC) and its potential interaction with another apoptosis-associated protein-glucose-regulated protein 78 (GRP78)-are as
Xin Zhou et al.
PloS one, 9(12), e115148-e115148 (2014-12-17)
We sought develop and characterize a diet-induced model of metabolic syndrome and its related diseases. The experimental animals (Spague-Dawley rats) were randomly divided into two groups, and each group was fed a different feed for 48 weeks as follows: 1)
Rong Xu et al.
Methods (San Diego, Calif.), 87, 11-25 (2015-04-19)
Secretion and exchange of extracellular vesicles (EVs) by most cell types is emerging as a fundamental biological process. Although much is known about EVs, there is still a lack of definition as to how many naturally occurring EV subtypes there
Hwee Ying Lim et al.
Biochemical and biophysical research communications, 460(4), 938-943 (2015-04-04)
Clear cell renal cell carcinoma (ccRCC) is characterized by the constitutive up-regulation of the hypoxia inducible factor-1. One of its target enzymes, pyruvate dehydrogenase (PDH) kinase 1 (PDHK1) showed increased protein expression in tumor as compared to patient-matched normal tissues.
Tao Yang et al.
Biochemical and biophysical research communications, 455(3-4), 298-304 (2014-12-03)
Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with hepatocellular carcinoma (HCC) development and progression. DNAJC6 (DNA/HSP40 homolog subfamily C member 6) encodes auxilin, which is responsible for juvenile Parkinsonism with phenotypic variability. However, the role of DNAJC6
Julie Bruyère et al.
Journal of molecular biology, 427(4), 775-791 (2014-10-01)
Mucopolysaccharidoses type III (MPSIII, Sanfilippo syndrome) are genetic diseases due to deficient heparan sulfate (HS) saccharide digestion by lysosomal exoglycanases. Progressive accumulation of undigested saccharides causes early-onset behavioural and cognitive symptoms. The precise role of these saccharides in the pathophysiological
Susanne Burdak-Rothkamm et al.
Cancer letters, 356(2 Pt B), 454-461 (2014-10-12)
Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct
Lan Gong et al.
Infection and immunity, 83(4), 1276-1285 (2015-01-22)
Melioidosis is an infectious disease of high mortality for humans and other animal species; it is prevalent in tropical regions worldwide. The pathogenesis of melioidosis depends on the ability of its causative agent, the Gram-negative bacterium Burkholderia pseudomallei, to enter
Xiangdi Yu et al.
Pharmacology, 95(5-6), 293-299 (2015-05-30)
Neuropathic pain is a well-known type of chronic pain caused by damage to the nervous system. Until recently, researchers have found that increased generation of reactive oxygen species (ROS) contributes to the development of exaggerated pain hypersensitivity during neuropathic pain.
Weiliang Jiang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 73, 40-47 (2015-07-28)
Pancreatic cancer (PC) is one of the most lethal human malignancies worldwide. Here, we demonstrated that xanthohumol (XN), the most abundant prenylated chalcone isolated from hops, inhibited the growth of cultured PC cells and their subcutaneous xenograft tumors. XN treatment
Bernhard J Jank et al.
Biomaterials, 61, 246-256 (2015-05-26)
The loss of an extremity is a disastrous injury with tremendous impact on a patient's life. Current mechanical prostheses are technically highly sophisticated, but only partially replace physiologic function and aesthetic appearance. As a biologic alternative, approximately 70 patients have
Ruben Magni et al.
Journal of translational medicine, 13, 346-346 (2015-11-06)
Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust
Tejinder Singh et al.
American journal of physiology. Renal physiology, 309(3), F189-F203 (2015-06-19)
ANG II type 1 receptor blockade (AT1R-BLK) is used extensively to slow down the progression of proteinuric kidney diseases. We hypothesized that AT1R-BLK provides podocyte protection through regulation of silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and
Xiupeng Lv et al.
Molecular medicine reports, 12(1), 1265-1271 (2015-03-18)
The identification of mutated genes in glioblastoma multiforme (GBM) is an essential step towards improving current understanding of the molecular mechanism underlying the disease and establishing novel targets for diagnostic and therapeutic purposes. The present study used direct sequencing to
Satoshi Nishiwada et al.
Anticancer research, 35(4), 2287-2297 (2015-04-12)
CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer. We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155
Wan Chen et al.
The Journal of steroid biochemistry and molecular biology, 152, 16-24 (2015-04-25)
Glucocorticoid-induced tendon rupture is very common in clinical practice, and the overall outcome of surgical suture repair is rather poor. The mechanism remains unclear, and effective treatments are still lacking. In the present study, we investigated the effect of dexamethasone
Jiying Liu et al.
FEBS letters, 588(23), 4497-4503 (2014-12-03)
Smad7 has a key role in apoptosis of mammalian ovarian granulosa cells (GCs), as it antagonizes and fine-tunes transforming growth factor β (TGFβ) signaling. This study demonstrates that miR-92a regulates GC apoptosis in pig ovaries by targeting Smad7 directly. The
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