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Novel caprine adeno-associated virus (AAV) capsid (AAV-Go.1) is closely related to the primate AAV-5 and has unique tropism and neutralization properties.
Arbetman, et al.
Journal of Virology, 79, 15238-15245 (2018)
Maulin M Patel et al.
Journal of the American Heart Association, 7(22), e010690-e010690 (2018-12-21)
Background The physiological function of ADTRP (androgen-dependent tissue factor pathway inhibitor regulating protein) is unknown. We previously identified ADTRP as coregulating with and supporting the anticoagulant activity of tissue factor pathway inhibitor in endothelial cells in vitro. Here, we studied the
Pierre Val et al.
Development (Cambridge, England), 134(12), 2349-2358 (2007-06-01)
It has been proposed that the mammalian adrenal cortex and gonad are derived from the same primordium present during early urogenital development. Molecular pathways involved in the differentiation of the adrenal cortex from the adrenogonadal primordium (AGP) have yet to
Toshiyuki Sakamaki et al.
Molecular and cellular biology, 26(14), 5449-5469 (2006-07-01)
The cyclin D1 gene encodes a regulatory subunit of the holoenzyme that phosphorylates and inactivates the pRb tumor suppressor to promote nuclear DNA synthesis. cyclin D1 is overexpressed in human breast cancers and is sufficient for the development of murine
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.
Nagel, et al.
Endocrinology, 142, 4721-4728 (2013)
Tobias B Kurth et al.
Arthritis and rheumatism, 63(5), 1289-1300 (2011-05-04)
We previously reported that human synovium contains cells that, after culture expansion, display properties of mesenchymal stem cells (MSCs). The objective of this study was to identify MSCs in native synovium in vivo. To identify stem cells in the synovium
Fiona E Holmes et al.
Psychopharmacology, 220(3), 619-625 (2011-10-05)
The neuropeptide galanin has been shown to modulate opiate dependence and withdrawal. These effects could be mediated via activation of one or more of the three distinct G protein-coupled receptors, namely galanin receptors 1 (GalR1), 2 (GalR2), and 3 (GalR3).
Eran Perlson et al.
Neuron, 45(5), 715-726 (2005-03-08)
How are phosphorylated kinases transported over long intracellular distances, such as in the case of axon to cell body signaling after nerve injury? Here, we show that the MAP kinases Erk1 and Erk2 are phosphorylated in sciatic nerve axoplasm upon
Wen-Hsin Hsu et al.
Scientific reports, 7(1), 12386-12386 (2017-09-30)
Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) plays pivotal roles in cell growth, cell differentiation, and cell fate determination. Although genome-wide studies have identified COUP-TFII binding on gene sets mainly involved in neural crest cell (NCC) development and craniofacial morphogenesis
Aki Takahashi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(16), 6452-6463 (2015-04-24)
Although the dorsal raphe nucleus (DRN) has long been linked to neural control of aggression, little is known about the regulatory influences of the DRN when an animal engages in either adaptive species-typical aggressive behavior or escalated aggression. Therefore it
David P J Hunt et al.
Stem cells (Dayton, Ohio), 26(1), 163-172 (2007-09-29)
Skin-derived precursor cells (SKPs) are multipotent neural crest-related stem cells that grow as self-renewing spheres and are capable of generating neurons and myelinating glial cells. SKPs are of clinical interest because they are accessible and potentially autologous. However, although spheres
Anna Benedykcinska et al.
Disease models & mechanisms, 9(2), 211-220 (2015-12-26)
Targeted cell- or region-specific gene recombination is widely used in the functional analysis of genes implicated in development and disease. In the brain, targeted gene recombination has become a mainstream approach to study neurodegeneration or tumorigenesis. The use of the
Su Jung Hwang et al.
Cell death and differentiation (2022-01-03)
Ninjurin1 (Ninj1), an adhesion molecule, regulates macrophage function in hyaloid regression, multiple sclerosis, and atherosclerosis. However, its biological relevance and the mechanism underlying its function in vascular network integrity have not been studied. In this study, we investigated the role
Tytteli A K Turunen et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 24(3), 620-635 (2015-12-17)
Plasmid-based Sleeping Beauty (SB) transposon vectors were developed and used to deliver genes for low-density lipoprotein and very-low-density lipoprotein receptors (LDLR and VLDLR, respectively) or lacZ reporter into liver of an LDLR-deficient mouse model of familial hypercholesterolemia (FH). SB transposase
Yuki Muranishi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16792-16807 (2011-11-18)
The molecular mechanisms underlying cell fate determination from common progenitors in the vertebrate CNS remain elusive. We previously reported that the OTX2 homeoprotein regulates retinal photoreceptor cell fate determination. While Otx2 transactivation is a pivotal process for photoreceptor cell fate
Emmi Kokki et al.
Genes, 9(9) (2018-09-12)
Vascular endothelial growth factor (VEGF) expression induces age-related macular degeneration (AMD), which is a common vision-threatening disease due to choroidal neovascularization and a fibrovascular membrane. We describe a mouse model of neovascular AMD with the local expression of human VEGF-A165
Mark A Titus et al.
PloS one, 7(1), e30192-e30192 (2012-01-25)
Prostate cancer (CaP) is the second leading cause of cancer death in American men. Androgen deprivation therapy is initially effective in CaP treatment, but CaP recurs despite castrate levels of circulating androgen. Continued expression of the androgen receptor (AR) and
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