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Lihua Wang et al.
The EMBO journal, 36(10), 1330-1347 (2017-04-06)
Pluripotent stem cells are known to display distinct metabolic phenotypes than their somatic counterparts. While accumulating studies are focused on the roles of glucose and amino acid metabolism in facilitating pluripotency, little is known regarding the role of lipid metabolism
Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities.
Yoshida, et al.
Modern Pathology, 30, 797-809 (2018)
Alejandro Vazquez-Martin et al.
Scientific reports, 2, 964-964 (2012-12-14)
The antidiabetic drug metformin efficiently circumvents the dilemma that in reducing the tumourigenicity of stem cells, their essence, specifically their pluripotency, must also be sacrificed. Metformin prevents the occurrence or drastically reduces the size and weight of teratoma-like masses after
Issei S Shimada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(23), 7926-7940 (2012-06-08)
In response to stroke, subpopulations of cortical reactive astrocytes proliferate and express proteins commonly associated with neural stem/progenitor cells such as glial fibrillary acidic protein (GFAP) and Nestin. To examine the stem cell-related properties of cortical reactive astrocytes after injury
Luis Zurkirchen et al.
Nature communications, 10(1), 2192-2192 (2019-05-18)
The transcription factor Yin Yang 1 (YY1) plays an important role in human disease. It is often overexpressed in cancers and mutations can lead to a congenital haploinsufficiency syndrome characterized by craniofacial dysmorphisms and neurological dysfunctions, consistent with a role
Daniel W Hagey et al.
Cell reports, 9(5), 1908-1920 (2014-12-09)
Organ formation and maintenance depends on slowly self-renewing stem cells that supply an intermediate population of rapidly dividing progenitors, but how this proliferative hierarchy is regulated is unknown. By performing genome-wide single-cell and functional analyses in the cortex, we demonstrate
Ben Newland et al.
MethodsX, 7, 100805-100805 (2020-02-20)
Neural precursor cells have been much studied to further our understanding of the far-reaching and controversial question of adult neurogenesis. Currently, differentiation of primary neural precursor cells from the mouse dentate gyrus via 2-dimentional in vitro culture yields low numbers
Hai-yong Zhao et al.
PloS one, 6(10), e27026-e27026 (2011-11-03)
Sox2 is a key component of the transcription factor network that maintains the pluripotent state of embryonic stem cells (ESCs). Sox2 is regulated by multiple post-translational modifications, including ubiquitination, sumoylation, acetylation and phosphorylation. Here we report that Sox2 is in
Joaquim Grego-Bessa et al.
eLife, 5, e12034-e12034 (2016-01-27)
Epithelial morphogenesis and stability are essential for normal development and organ homeostasis. The mouse neural plate is a cuboidal epithelium that remodels into a columnar pseudostratified epithelium over the course of 24 hr. Here we show that the transition to
E M Alexandrova et al.
Cell death and differentiation, 20(12), 1698-1708 (2013-09-10)
Somatic cells can be converted into induced pluripotent stem cells (iPSCs) by forced expression of various combinations of transcription factors, but the molecular mechanisms of reprogramming are poorly understood. Specifically, evidence that the reprogramming process can take many distinct routes
Mette C Jørgensen et al.
Development (Cambridge, England), 145(17) (2018-08-11)
Mutations in Hes1, a target gene of the Notch signalling pathway, lead to ectopic pancreas by a poorly described mechanism. Here, we use genetic inactivation of Hes1 combined with lineage tracing and live imaging to reveal an endodermal requirement for
Yoon Kyung Chang et al.
Stem cells (Dayton, Ohio), 36(12), 1851-1862 (2018-10-03)
There are no effective treatments for corneal endothelial diseases, except for corneal transplantation, as human corneal endothelial cells (hCECs) do not regenerate. The regeneration of hCECs could be induced through regulation of the expression of specific genes. In this study
Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.
Arnold, K; Sarkar, A; Yram, MA; Polo, JM; Bronson, R; Sengupta, S; Seandel, M; Geijsen et al.
Cell Stem Cell null
Wnt/?-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium.
Pacheco-Pinedo, EC; Durham, AC; Stewart, KM; Goss, AM; Lu, MM; Demayo, FJ; Morrisey, EE
The Journal of Clinical Investigation null
Valya Ramakrishnan et al.
EBioMedicine, 55, 102736-102736 (2020-05-04)
Recurrence after radiation therapy is nearly universal for glioblastomas, the most common form of adult brain cancer. The study aims to define clinically pertinent mechanisms underlying this recurrence. microRNA (miRNA) profiling was performed using matched pre- and post-radiation treatment glioblastoma
Transcription factor Isl1 is dispensable for the development of the mouse prosensory region.
He, et al.
Cytotechnology, 72, 407-414 (2020)
Celine Banal et al.
Stem cell research, 48, 101936-101936 (2020-08-17)
Mutations of SOX10 result in a broad range of phenotypes including Waardenburg syndrome (WS types 2 and 4) that can be found in association with peripheral demyelinating neuropathy and/or central dysmyelinating leukodystrophy. Here, we generated induced pluripotent stem cells (iPSCs)
Joaquim Egea et al.
Genes & development, 22(23), 3349-3362 (2008-12-06)
During early mouse development, the anterior visceral endoderm (AVE) secretes inhibitor and activator signals that are essential for establishing the anterior-posterior (AP) axis of the embryo and for restricting mesoderm formation to the posterior epiblast in the primitive streak (PS)
Lauren N Miterko et al.
Neural development, 14(1), 6-6 (2019-03-15)
Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcoming initial defects
Takashi Shingu et al.
Nature genetics, 49(1), 75-86 (2016-11-15)
Stem cells, including cancer stem cells (CSCs), require niches to maintain stemness, yet it is unclear how CSCs maintain stemness in the suboptimal environment outside their niches during invasion. Postnatal co-deletion of Pten and Trp53 in mouse neural stem cells
Antonella Carella et al.
International journal of cancer, 146(2), 373-387 (2019-06-19)
Loss of 5-hydroxymethylcytosine (5hmC) has been associated with mutations of the ten-eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild-type TET genes can also display low 5hmC levels, suggesting that other mechanisms involved in gene regulation
Shlomit Edri et al.
Development (Cambridge, England), 146(10) (2019-04-27)
The caudal lateral epiblast of mammalian embryos harbours bipotent progenitors that contribute to the spinal cord and the paraxial mesoderm in concert with the body axis elongation. These progenitors, called neural mesodermal progenitors (NMPs), are identified as cells that co-express
Daniel Medina-Cano et al.
eLife, 7 (2018-10-13)
Proper brain development relies highly on protein N-glycosylation to sustain neuronal migration, axon guidance and synaptic physiology. Impairing the N-glycosylation pathway at early steps produces broad neurological symptoms identified in congenital disorders of glycosylation. However, little is known about the
Priyanka Arya et al.
Developmental biology, 408(1), 41-55 (2015-10-13)
The C-terminal Eps15 homology domain-containing (EHD) proteins play a key role in endocytic recycling, a fundamental cellular process that ensures the return of endocytosed membrane components and receptors back to the cell surface. To define the in vivo biological functions
Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements.
Chang, W; Lin, Z; Kulessa, H; Hebert, J; Hogan, BL; Wu, DK
PLoS Genetics null
Stephen M Ostrowski et al.
Development (Cambridge, England), 142(14), 2533-2544 (2015-07-04)
Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to create additional Merkel cells. In embryos, ectopic
Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation.
Wong YH, Lu AC, Wang YC, Cheng HC, Chang C, Chen PH, Yu JY, Fann MJ
The Journal of Neuroscience null
Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells.
Card, DA; Hebbar, PB; Li, L; Trotter, KW; Komatsu, Y; Mishina, Y; Archer, TK
Molecular and cellular biology null
Eunhye Kim et al.
BMC veterinary research, 14(1), 331-331 (2018-11-09)
The porcine brain is gyrencephalic with similar gray and white matter composition and size more comparable to the human rather than the rodent brain; however, there is lack of information about neural progenitor cells derived from this model. Here, we
Yajing Meng et al.
Frontiers in cell and developmental biology, 9, 702462-702462 (2021-09-28)
Epigenetic modifications play a crucial role in neurogenesis, learning, and memory, but the study of their role in early neuroectoderm commitment from pluripotent inner cell mass is relatively lacking. Here we utilized the system of directed neuroectoderm differentiation from human
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