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Taro Chaya et al.
The EMBO journal, 33(11), 1227-1242 (2014-05-07)
Cilia and flagella are formed and maintained by intraflagellar transport (IFT) and play important roles in sensing and moving across species. At the distal tip of the cilia/flagella, IFT complexes turn around to switch from anterograde to retrograde transport; however
Melanie Greter et al.
Immunity, 37(6), 1050-1060 (2012-11-28)
Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control macrophage development, maintenance, and function. The development of both Langerhans cells (LCs) and microglia is highly dependent on Csf-1 receptor signaling but independent of Csf-1. Here we show that in both
Xia Chen et al.
PloS one, 6(2), e17072-e17072 (2011-03-02)
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neurons is highly variable. Here we address the roles of the origin of the tissue and its pre-implantation preparation, and show that both are critical.
Mirosława Mańko et al.
The Journal of physiology, 589(Pt 8), 1911-1925 (2011-01-13)
Intercalated cells (ITCs) of the amygdala are clusters of GABAergic cells that surround the basolateral complex of the amygdala (BLA). Growing evidence suggests that ITCs are required for the expression of fear extinction. The main intercalated nucleus (Im) is the
Activation of p38 MAP kinase is involved in central neuropathic pain following spinal cord injury.
Crown, ED; Gwak, YS; Ye, Z; Johnson, KM; Hulsebosch, CE
Experimental neurology null
Peter M LoCoco et al.
eLife, 6 (2017-11-11)
Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy, leading to debilitating neuropathic pain. No effective treatment for CIPN exists, short of dose-reduction which worsens cancer prognosis. Here, we report that stimulation of
Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain.
Herculano-Houzel, Suzana and Lent, Roberto
The Journal of Neuroscience, 25, 2518-2521 (2005)
Martin W Breuss et al.
Human molecular genetics, 26(2), 258-269 (2016-12-26)
The integrity and dynamic properties of the microtubule cytoskeleton are indispensable for the development of the mammalian brain. Consequently, mutations in the genes that encode the structural component (the α/β-tubulin heterodimer) can give rise to severe, sporadic neurodevelopmental disorders. These
Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment.
Fernandez, et al.
Neuron, 102, 1127-1142 (2020)
Lauren Y Shields et al.
The Journal of biological chemistry, 296, 100469-100469 (2021-02-28)
Alterations in mitochondrial fission may contribute to the pathophysiology of several neurodegenerative diseases, including Alzheimer's disease (AD). However, we understand very little about the normal functions of fission or how fission disruption may interact with AD-associated proteins to modulate pathogenesis.
Ofri Bar et al.
Fluids and barriers of the CNS, 17(1), 27-27 (2020-04-03)
Several secreted factors have been identified as drivers of cerebral vasculature development and inducers of blood-brain barrier (BBB) differentiation. Vascular endothelial growth factor A (VEGF-A) is central for driving cerebral angiogenesis and Wnt family factors (Wnt7a, Wnt7b and norrin) are
Emiko Fukuzaki et al.
Neurochemistry international, 52(7), 1358-1364 (2008-04-05)
Ovarian hormone decline after menopause may influence cognitive performance and increase the risk for Alzheimer's disease (AD) in women. Amyloid-beta peptide (Abeta) has been proposed to be the primary cause of AD. In this study, we examined whether ovariectomy (OVX)
Ha Neui Kim et al.
International journal of molecular medicine, 39(6), 1393-1402 (2017-05-11)
In the present study, we investigated whether treadmill training and electroacupuncture (EA) have autonomous or synergistic beneficial effects on deficits caused by neonatal hypoxia‑ischemia in Sprague-Dawley rats. For this purpose, rats subjected to hypoxia-ischemia underwent treadmill training and EA stimulation from 4 to 8 weeks
Jingjing Zhang et al.
Translational neurodegeneration, 7, 35-35 (2019-01-05)
Neuron-microglia communication plays a crucial role in the motor neurons (MNs) death in amyotrophic lateral sclerosis (ALS). Neurons can express chemokine (C-X3-C motif) ligand 1 (CX3CL1), which mediates microglial activation via interacting with its sole receptor CX3CR1 in microglia. In
Zachary J Hall et al.
PloS one, 7(7), e40060-e40060 (2012-07-14)
The song-control system is a network of discrete nuclei in the songbird brain that controls the production and learning of birdsong and exhibits some of the best-studied neuroplasticity found in the adult brain. Photoperiodic growth of the song-control system during
Jingqi Yan et al.
PloS one, 6(11), e27798-e27798 (2011-11-24)
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia. Here we show in an ischemic stroke model of rats that inhibiting HIF-1 and its
Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise.
Merkley, CM; Jian, C; Mosa, A; Tan, YF; Wojtowicz, JM
Frontiers in Neuroscience null
V Baekelandt et al.
Journal of virology, 74(23), 11278-11285 (2000-11-09)
How DNA is repaired after retrovirus integration is not well understood. DNA-dependent protein kinase (DNA-PK) is known to play a central role in the repair of double-stranded DNA breaks. Recently, a role for DNA-PK in retroviral DNA integration has been
Reesha R Patel et al.
Brain, behavior, and immunity, 75, 208-219 (2019-02-23)
The interleukin-1 system (IL-1) is a prominent pro-inflammatory pathway responsible for the initiation and regulation of immune responses. Human genetic and preclinical studies suggest a critical role for IL-1β signaling in ethanol drinking and dependence, but little is known about
François-Xavier Blaudin de Thé et al.
The EMBO journal, 37(15) (2018-06-27)
LINE-1 mobile genetic elements have shaped the mammalian genome during evolution. A minority of them have escaped fossilization which, when activated, can threaten genome integrity. We report that LINE-1 are expressed in substantia nigra ventral midbrain dopaminergic neurons, a class
When larger brains do not have more neurons: increased numbers of cells are compensated by decreased average cell size across mouse individuals.
Herculano-Houzel, S; Messeder, DJ; Fonseca-Azevedo, K; Pantoja, NA
Frontiers in Neuroanatomy null
Takashi Shingu et al.
Nature genetics, 49(1), 75-86 (2016-11-15)
Stem cells, including cancer stem cells (CSCs), require niches to maintain stemness, yet it is unclear how CSCs maintain stemness in the suboptimal environment outside their niches during invasion. Postnatal co-deletion of Pten and Trp53 in mouse neural stem cells
Thomas Jungas et al.
The Journal of cell biology, 214(5), 555-569 (2016-08-24)
Cytokinesis is the last step of cell division, culminating in the physical separation of daughter cells at the end of mitosis. Cytokinesis is a tightly regulated process that until recently was mostly viewed as a cell-autonomous event. Here, we investigated
Chiara Rolando et al.
The European journal of neuroscience, 31(8), 1340-1351 (2010-04-14)
Stem or progenitor cells acquire specific regional identities during early ontogenesis. Nonetheless, there is evidence that cells heterotopically transplanted to neurogenic regions of the developing or mature central nervous system may switch their fate to adopt host-specific phenotypes. Here, we
Erik A Johnson et al.
Journal of neuroinflammation, 8, 41-41 (2011-05-04)
Exposure to the nerve agent soman (GD) causes neuronal cell death and impaired behavioral function dependent on the induction of status epilepticus (SE). Little is known about the maturation of this pathological process, though neuroinflammation and infiltration of neutrophils are
Jenni E Anttila et al.
eNeuro, 5(2) (2018-05-17)
Ischemic stroke is the leading cause of disability, and effective therapeutic strategies are needed to promote complete recovery. Neuroinflammation plays a significant role in stroke pathophysiology, and there is limited understanding of how it affects recovery. The aim of this
Abraham J Langseth et al.
Scientific reports, 7(1), 5685-5685 (2017-07-20)
A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both loss-of-function and gain-of-function mechanisms have been proposed to underlie this disease, but the pathogenic pathways
Neural pathways underlying lactate-induced panic.
Johnson, PL; Truitt, WA; Fitz, SD; Lowry, CA; Shekhar, A
Neuropsychopharmacology null
Alberto Jiménez-Maldonado et al.
Biochimica et biophysica acta. Molecular basis of disease, 1864(1), 24-33 (2017-10-12)
Chronic fructose ingestion is linked to the global epidemic of metabolic syndrome (MetS), and poses a serious threat to brain function. We asked whether a short period (one week) of fructose ingestion potentially insufficient to establish peripheral metabolic disorder could
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