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Domenica Taruscio et al.
Public health genomics, 17(2), 115-123 (2014-04-10)
Congenital anomalies (CA) are the paradigm example of rare diseases liable to primary prevention actions due to the multifactorial etiology of many of them, involving a number of environmental factors together with genetic predispositions. Yet despite the preventive potential, lack
Helene McNulty et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 348-354 (2013-06-26)
Scientific evidence supports a number of roles for folate in maintaining health from early life to old age. Folate is required for one-carbon metabolism, including the remethylation of homocysteine to methionine; thus elevated plasma homocysteine reflects functional folate deficiency. Optimal
Suranjana Mukherjee et al.
PloS one, 10(2), e0118153-e0118153 (2015-02-28)
Natural Killer (NK) cells perform many functions that depend on actin assembly, including adhesion, chemotaxis, lytic synapse assembly and cytolysis. HS1, the hematopoietic homolog of cortactin, binds to Arp2/3 complex and promotes actin assembly by helping to form and stabilize
Alvin Nursalim et al.
Acta medica Indonesiana, 45(2), 150-156 (2013-06-19)
to determine whether the administration of folic acid, vitamin B6 and vitamin B12 would lead to reduction of cardiovascular complication and mortality among CKD patients. a search was conducted on PubMed and Google. The selection of title and abstract was
Vanessa R da Silva et al.
American journal of physiology. Endocrinology and metabolism, 307(1), E93-101 (2014-05-16)
Low vitamin B-6 nutritional status is associated with increased risk for cardiovascular disease and certain cancers. Pyridoxal 5'-phosphate (PLP) serves as a coenzyme in many cellular processes, including several reactions in one-carbon (1C) metabolism and the transsulfuration pathway of homocysteine
Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis.
Beverley Shea
Journal of evidence-based medicine, 6(3), 202-203 (2013-12-12)
Mingjun Xuan et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(11), 2255-2260 (2014-04-18)
The synthesis of an innovative self-propelled Janus nanomotor with a diameter of about 75 nm that can be used as a drug carrier is described. The Janus nanomotor is based on mesoporous silica nanoparticles (MSNs) with chromium/platinum metallic caps and
Mariano Licciardi et al.
Journal of biomedical nanotechnology, 9(6), 949-964 (2013-07-19)
Dual targeted drug delivery systems represent a potential platform for developing efficient vector to tumor sites. In this study we evaluated a folate- and magnetic-targeted nanocarriers based on 10 nm iron oxide nanodomais coated with the properly synthesized and characterized
Van-Minh Le et al.
European journal of medicinal chemistry, 92, 882-889 (2015-02-14)
Traditional chemotherapeutic drugs remain the major treatment for advanced colorectal cancer. However, due to the lack of tumor specificity these drug also destroy healthy tissue and organs, which has been the main reason for treatment failure and mortality. Folate-based drug
Jack Metz
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 103(12 Suppl 1), 978-981 (2013-12-05)
Reports from some Western countries indicate that mandatory folate food fortification (FFF) has substantially reduced the prevalence of folate deficiency, leading to calls for folate testing following FFF to be limited to specific indications such as macrocytic anaemia. This is
W Al-Darzi et al.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 20(9), 561-568 (2014-10-25)
Egypt has a high incidence of neural tube defects. Folic acid supplementation in the periconceptional period is known to lower the risk of such defects. This cross-sectional study aimed to measure the level of knowledge about periconceptional folic acid use
Cheng Yang et al.
Journal of nanoscience and nanotechnology, 13(10), 6553-6559 (2013-11-20)
In this study, thermosensitive and folate functionalized poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer was synthesized. The structure and molecular weight of the copolymer were confirmed by 1H NMR, FT-IR and GPC, respectively. The lower critical solution temperature (LCST) of
Sonia Trombino et al.
Anticancer research, 33(11), 4847-4854 (2013-11-14)
The aim of the present study was to prepare a hydrogel, based on ellagic acid and glycine, embedded with folic acid, as a subcutaneous implant for the treatment of breast cancer. The function of folic acid is to selectively and
P M Tedeschi et al.
Cell death & disease, 4, e877-e877 (2013-10-26)
Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed
Growth and nutrition in children with food allergy requiring amino acid-based nutritional formulas.
Karen A Robbins et al.
The Journal of allergy and clinical immunology, 134(6), 1463-1466 (2014-12-03)
Per Ashorn et al.
The American journal of clinical nutrition, 101(2), 387-397 (2015-02-04)
Small birth size, often associated with insufficient maternal nutrition, contributes to a large share of global child undernutrition, morbidity, and mortality. We developed a small-quantity lipid-based nutrient supplement (SQ-LNS) to enrich the diets of pregnant women. The objective was to
Xiali Zhu et al.
Journal of drug targeting, 22(9), 822-828 (2014-06-26)
This report focuses on the in vitro and in vivo anti-cancer effects evaluation of targeting and photothermal sensitive solid lipid nanoparticles (SLN) for the co-loading of docetaxel (DTX), oxidized single-walled carbon nanotubes (OSWNT) and folic acid (FA). Compared with free
Henrik Kempe et al.
Pharmaceutical research, 32(2), 375-388 (2014-08-12)
To develop and evaluate molecularly imprinted nanocarriers for sustained release of erythromycin in physiological buffer media. Erythromycin-imprinted poly(methacrylic acid-co-trimethylolpropane trimethacrylate) nanocarriers and corresponding control nanocarriers were prepared by free-radical precipitation polymerization. The nanocarriers were characterized by transmission electron microscopy, dynamic
Barbara Anne Jennings et al.
Cancer letters, 356(2 Pt A), 224-230 (2014-03-13)
Folate was identified as an essential micronutrient early in the twentieth century and anti-folate chemotherapy such as 5-fluorouracil (5-FU) has been central to the medical management of solid tumours including colorectal cancer for more than five decades. In the intervening
Flow injection chemiluminometric determination of folic acid in pharmaceutical formulations
Al-Warthan.AA
Analytical Sciences, 10(6), 919-922 (1994)
Qiusha Tang et al.
PloS one, 9(9), e106483-e106483 (2014-09-05)
A practical and effective strategy for synthesis of Folate-NIR 797-conjugated Magnetic Albumin Nanospheres (FA-NIR 797-MAN) was developed. For this strategy, Magnetic Albumin Nanospheres (MAN), composed of superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA), were covalently conjugated with
Sachin Yadav et al.
Artificial cells, nanomedicine, and biotechnology, 43(2), 93-102 (2013-11-08)
Breast cancer accounts for 23% of all newly occurring cancers in women worldwide and represents 13.7% of all cancer deaths. Available chemotherapeutic agents are limited largely due to the low accumulation of chemotherapeutics at the tumors relative to their accumulation
Alan H Maurer et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(5), 701-704 (2014-04-16)
Folate receptor (FR) can be used as a therapeutic target because of its expression on different epithelial cancers, such as ovarian, non-small cell lung, endometrial, and breast cancer. Assessing FR expression in tumors may help to identify patients who can
Maika Kissei et al.
Drug metabolism and pharmacokinetics, 29(5), 367-372 (2014-04-04)
Folic acid (FA) is a water-soluble vitamin, and orally ingested FA is absorbed from the small intestine by the proton-coupled folate transporter (PCFT). In the present study, we investigated whether epigallocatechin gallate (EGCG), one of the tea catechins, affects the
Daniel E Roth et al.
The American journal of clinical nutrition, 100(6), 1587-1595 (2014-11-21)
Prenatal calcium and iron supplements are recommended in settings of low dietary calcium intake and high prevalence of anemia. However, calcium administration may inhibit iron absorption. To overcome calcium-iron interactions, we developed a multi-micronutrient powder containing iron (60 mg), folic
Zhiyao He et al.
Journal of biomedical nanotechnology, 9(5), 833-844 (2013-06-28)
Folate receptor alpha (FRalpha) is overexpressed on ovarian cancer cells and is a promising molecular target for ovarian cancer gene therapy, but there was still no related report. In this study, folate modified cationic liposomes (F-PEG-CLPs) for ovarian cancer gene
Valproate and folic acid in pregnancy: associations with autism.
Peter Baxter
Developmental medicine and child neurology, 56(7), 604-604 (2014-06-14)
David W Baker et al.
Acta biomaterialia, 10(7), 2945-2955 (2014-04-15)
Plasticity of macrophage (MΦ) phenotypes exist in a spectrum from classically activated (M1) cells, to alternatively activated (M2) cells, contributing to both the normal healing of tissues and the pathogenesis of implant failure. Here, folate- and mannose-based optical probes were
Aline H Guariento et al.
International journal of cancer, 135(1), 7-18 (2013-12-05)
The steady increase in the incidence and mortality of hepatocellular carcinoma (HCC) signifies a crucial need to understand better its pathogenesis to improve clinical management and prevention of the disease. The aim of this study was to investigate molecular mechanisms
Yong Yu et al.
Die Pharmazie, 68(9), 732-743 (2013-10-24)
Raltitrexed (RTX) has shown clinical activity in a variety of advanced solid tumours. Its oral bioavailability is low and its intestinal absorption mechanism is not clear. In the present study, the absorption mechanism of RTX in the small intestine was
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